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    MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) [ Homo sapiens (human) ]

    Gene ID: 4361, updated on 14-May-2013
    Official Symbol
    MRE11Aprovided by HGNC
    Official Full Name
    MRE11 meiotic recombination 11 homolog A (S. cerevisiae)provided by HGNC
    Primary source
    HGNC:7230
    See related
    HPRD:02889; MIM:600814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATLD; HNGS1; MRE11; MRE11B
    Summary
    This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Location :
    11q21
    Sequence :
    Chromosome: 11; NC_000011.9 (94150466..94227040, complement)
    See MRE11A in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene folate receptor 4, delta (putative) Neighboring gene G protein-coupled receptor 83 Neighboring gene microRNA 548l Neighboring gene ankyrin repeat domain 49 Neighboring gene uncharacterized LOC643037

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork. van Pel DM, et al. G3 (Bethesda), 2013 Feb. PMID 23390603.
    2. The histone acetyltransferase component TRRAP is targeted for destruction during the cell cycle. Ichim G, et al. Oncogene, 2013 Jan 14. PMID 23318449.
    3. The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination. Lu CS, et al. J Biol Chem, 2012 Dec 21. PMID 23115235.
    4. TIS21(/BTG2/PC3) accelerates the repair of DNA double strand breaks by enhancing Mre11 methylation and blocking damage signal transfer to the Chk2(T68)-p53(S20) pathway. Choi KS, et al. DNA Repair (Amst), 2012 Dec 1. PMID 23089312.
    5. Expression of TIP60 (tat-interactive protein) and MRE11 (meiotic recombination 11 homolog) predict treatment-specific outcome of localised invasive bladder cancer. Laurberg JR, et al. BJU Int, 2012 Dec. PMID 23046361.

    See all (188) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. TIS21 regulates DNA double strand break repair and apoptosis via increasing Mre11 methylation.
      Title: TIS21(/BTG2/PC3) accelerates the repair of DNA double strand breaks by enhancing Mre11 methylation and blocking damage signal transfer to the Chk2(T68)-p53(S20) pathway.
    2. MRE11 was shown to be a predictive marker for DSS after radiotherapy. * We have shown that TIP60 and MRE11 hold the potential to guide patients with invasive bladder cancer to either cystectomy or radiotherapy.
      Title: Expression of TIP60 (tat-interactive protein) and MRE11 (meiotic recombination 11 homolog) predict treatment-specific outcome of localised invasive bladder cancer.
    3. High MRE11 expression in breast cancer cells was associated with more malignant behavior. MRE11 may be a novel oncoprotein & may serve as a new therapeutic target against breast cancer.
      Title: Role of MRE11 in cell proliferation, tumor invasion, and DNA repair in breast cancer.
    4. Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses
      Title: Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.
    5. Mre11 and Nbs1 are sumoylated during Ad5 infection and the E4-ORF3 protein is necessary and sufficient to induce SUMO conjugation. Relocalization of Mre11 and Nbs1 into E4-ORF3 nuclear tracks is required for this modification to occur.
      Title: Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paralog-specific mechanism.
    6. Study identifies by whole-exome resequencing, mutations of MRE11, ZNF423, and CEP164 as causing Nephronophthisis-related ciliopathies.
      Title: Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.
    7. findings not only show that Mre11 activity is required for the survival of BRCA2 mutant cells but also elucidate roles for both the BRCA2 and PARP1 proteins in protecting stalled replication forks
      Title: Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1.
    8. Review of the current literature suggests that hMRE11 is most likely involved with the MMR pathway in a more complex fashion than simply being a MMR target gene.
      Title: Causal link between microsatellite instability and hMRE11 dysfunction in human cancers.
    9. Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex.
      Title: Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex.
    10. The authors show that, in human and mouse, Mre11 controls these events through a direct interaction with CDK2 that is required for CtIP phosphorylation and BRCA1 interaction in normally dividing cells.
      Title: Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.
    Submit: New GeneRIF Correction See all (99)

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005582.1 NP_002476.2 NBN    BIND  PubMed Mre11 interacts with Nbs1 
    NP_005582.1 NP_036356.1 NEK1    BIND  PubMed NEK1 interacts with MRE11 
    NP_005582.1 NP_005723.2 RAD50    BIND  PubMed Mre11 interacts with Rad50 
    P49959 Q13315 ATM    HPRD  PubMed  
    P49959 P24864 CCNE1    HPRD  PubMed  
    P49959 Q96SD1 DCLRE1C    HPRD  PubMed  
    P49959 Q09472 EP300    HPRD  PubMed  
    P49959 Q9BXW9 FANCD2    HPRD  PubMed  
    P49959 P16104 H2AFX    HPRD  PubMed  
    P49959 P18858 LIG1    HPRD  PubMed  
    P49959 O60934 NBN    HPRD  PubMed  
    P49959 Q96PY6 NEK1    HPRD  PubMed  
    P49959 Q92878 RAD50    HPRD  PubMed  
    P49959 P12956 XRCC6    HPRD  PubMed  
    BioGRID:110501 BioGRID:106541 ABCF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:107776 ATF2    BioGRID  PubMed Co-localization 
    NP_000042.2 ATM    BIND  PubMed ATM interacts with MRE11A (Mre11). 
    BioGRID:110501 BioGRID:106962 ATM    BioGRID  PubMed Affinity Capture-Western; Co-purification; Protein-peptide 
    BioGRID:110501 BioGRID:107027 ATR    BioGRID  PubMed Protein-peptide 
    BioGRID:110501 BioGRID:107047 BACH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110501 BioGRID:107056 BARD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110501 BioGRID:107110 BLM    BioGRID  PubMed Co-purification 
    BioGRID:110501 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex 
    BioGRID:110501 BioGRID:119650 C14orf166    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:119569 C22orf28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:107338 CCNE1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110501 BioGRID:113915 CDC45    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:110501 BioGRID:122331 DCLRE1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110501 BioGRID:122170 DCLRE1C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110501 BioGRID:108019 DDX1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110501 BioGRID:108025 DHX9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:114409 EIF2B2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:114408 EIF2B3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:108603 FLII    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:115174 GINS1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:110501 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:110501 BioGRID:109422 HNRNPA2B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:110751 HNRNPM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:109433 HNRNPU    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:115887 IGF2BP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:109821 ILF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110501 BioGRID:110166 LIG1    BioGRID  PubMed Two-hybrid 
    BioGRID:110501 BioGRID:114642 LRRFIP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:114515 MAP7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:110339 MCM2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:110501 BioGRID:115014 MDC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Protein-peptide; Reconstituted Complex 
    BioGRID:110501 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110501 BioGRID:110438 MLH1    BioGRID  PubMed Co-purification 
    BioGRID:110501 BioGRID:110501 MRE11A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110501 BioGRID:110573 MSH2    BioGRID  PubMed Co-purification 
    BioGRID:110501 BioGRID:109211 MSH6    BioGRID  PubMed Co-purification 
    NP_002476.2 NBN    BIND  PubMed NBS1 interacts with MRE11A (Mre11). 
    BioGRID:110501 BioGRID:110763 NBN    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-localization; Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:110501 BioGRID:110825 NEK1    BioGRID  PubMed Two-hybrid 
    BioGRID:110501 BioGRID:117421 NELFB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:120787 NLRP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110501 BioGRID:110899 NMT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:116625 PAXIP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110501 BioGRID:111418 POLA1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:110501 BioGRID:111577 PRKDC    BioGRID  PubMed Protein-peptide 
    BioGRID:110501 BioGRID:109512 PRMT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110501 BioGRID:111797 QARS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:115417 RAD50    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification 
    BioGRID:110501 BioGRID:114797 RECQL5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110501 BioGRID:111913 RFC1    BioGRID  PubMed Co-purification 
    BioGRID:110501 BioGRID:111916 RFC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:114492 RNF8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110501 BioGRID:119308 RPL26L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:112074 RPL27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110501 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:112873 TERF2    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:110501 BioGRID:119942 TERF2IP    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:110501 BioGRID:112967 TMPO    BioGRID  PubMed Co-fractionation 
    NP_000537.2 TP53    BIND  PubMed Mre11 interacts with p53. This interaction was modeled on a demonstrated interaction between Mre11 and p53 both from African green monkey. 
    BioGRID:110501 BioGRID:113900 TRRAP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110501 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:113866 USP11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110501 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110501 BioGRID:114101 YBX3    BioGRID  PubMed Affinity Capture-MS 
    • Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks, organism-specific biosystem (from REACTOME)
      Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks, organism-specific biosystemAssembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks involves the formation of RAD50:MRE11 complex, association of RAD50:MRE11 complex with NBS1 through MRE11 and association of the...
    • BARD1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      BARD1 signaling events, organism-specific biosystem
      BARD1 signaling events
    • BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem (from KEGG)
      BRCA1-associated genome surveillance complex (BASC), organism-specific biosystemStructural complex; Genetic information processing; Repair system
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. These cellular mechanisms that must cope with the plethora of DNA base pair ad...
    • DNA damage response, organism-specific biosystem (from WikiPathways)
      DNA damage response, organism-specific biosystemThis is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two ...
    • Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
      Double-Strand Break Repair, organism-specific biosystemNumerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-s...
    • Homologous Recombination Repair, organism-specific biosystem (from REACTOME)
      Homologous Recombination Repair, organism-specific biosystemThe HRR pathway is an "error free" DNA repair mechanism that utilizes information encoded by homologous sequence to repair double-strand breaks (DSBs). HRR acts on DSBs occurring within replicated DN...
    • Homologous recombination, organism-specific biosystem (from WikiPathways)
      Homologous recombination, organism-specific biosystemHomologous recombination, also known as general recombination, is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical strands of DNA. Source:...
    • Homologous recombination, organism-specific biosystem (from KEGG)
      Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • Homologous recombination, conserved biosystem (from KEGG)
      Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • Homologous recombination repair of replication-independent double-strand breaks, organism-specific biosystem (from REACTOME)
      Homologous recombination repair of replication-independent double-strand breaks, organism-specific biosystemHomologous recombination repair of replication-independent double-strand breaks requires the activation of ATM followed by ATM mediated phosphorylation of DNA repair proteins. DNA repair and signalin...
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Integrated Cancer pathway, organism-specific biosystem (from WikiPathways)
      Integrated Cancer pathway, organism-specific biosystem
      Integrated Cancer pathway
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • MRN complex, organism-specific biosystem (from KEGG)
      MRN complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
    • MRN complex relocalizes to nuclear foci, organism-specific biosystem (from REACTOME)
      MRN complex relocalizes to nuclear foci, organism-specific biosystemMRN complexes localize to nuclear foci in response to double-strand breaks and have been implicated in DNA end-processing during homologous recombination repair (Trujillo et al., 1998). The MRN comp...
    • Meiosis, organism-specific biosystem (from REACTOME)
      Meiosis, organism-specific biosystemDuring meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing...
    • Meiotic Recombination, organism-specific biosystem (from REACTOME)
      Meiotic Recombination, organism-specific biosystemMeiotic recombination exchanges segments of duplex DNA between chromosomal homologs, generating genetic diversity (reviewed in Handel and Schimenti 2010, Inagaki et al. 2010, Cohen et al. 2006). Ther...
    • Non-homologous end joining, organism-specific biosystem (from WikiPathways)
      Non-homologous end joining, organism-specific biosystem(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because...
    • Non-homologous end-joining, organism-specific biosystem (from KEGG)
      Non-homologous end-joining, organism-specific biosystemNonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX c...
    • Non-homologous end-joining, conserved biosystem (from KEGG)
      Non-homologous end-joining, conserved biosystemNonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX c...
    • Prostate Cancer, organism-specific biosystem (from WikiPathways)
      Prostate Cancer, organism-specific biosystem
      Prostate Cancer
    • Recruitment of repair and signaling proteins to double-strand breaks, organism-specific biosystem (from REACTOME)
      Recruitment of repair and signaling proteins to double-strand breaks, organism-specific biosystemFollowing exposure to ionizing radiation, a number of recombination/repair proteins and complexes relocalize to nuclear foci that are believed to correspond to the sites of double-strand breaks. Thes...
    • Regulation of Telomerase, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Telomerase, organism-specific biosystem
      Regulation of Telomerase

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    3'-5' exonuclease activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    contributes_to ATP-dependent DNA helicase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    double-stranded DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    endodeoxyribonuclease activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclease activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    single-stranded DNA specific endodeoxyribonuclease activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA duplex unwinding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    DNA recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    DNA repair TAS
    Traceable Author Statement
    more info
    		  
    cell cycle checkpoint IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    double-strand break repair TAS
    Traceable Author Statement
    more info
    		  
    double-strand break repair via homologous recombination TAS
    Traceable Author Statement
    more info
    		  
    double-strand break repair via nonhomologous end joining TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nucleic acid phosphodiester bond hydrolysis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    reciprocal meiotic recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of mitotic recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    synapsis IEA
    Inferred from Electronic Annotation
    more info
    		  
    telomere maintenance via telomerase TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Mre11 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Mre11 complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    colocalizes_with chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    double-strand break repair protein MRE11A
    Names
    double-strand break repair protein MRE11A
    AT-like disease
    MRE11 homolog 1
    MRE11 homolog A
    endo/exonuclease Mre11
    meiotic recombination 11 homolog 1
    meiotic recombination 11 homolog A
    DNA recombination and repair protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007261.1 RefSeqGene

      Range
      5001..81575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_85

    mRNA and Protein(s)

    1. NM_005590.3 → NP_005581.2  double-strand break repair protein MRE11A isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform 2 lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AP000765, BC017823, BF574168, U37359
      Consensus CDS
      CCDS8298.1
      UniProtKB/Swiss-Prot
      P49959
      UniProtKB/TrEMBL
      Q05D78
      Conserved Domains (3) summary
      TIGR00583
      Location:10 – 402
      Blast Score: 1274
      mre11; DNA repair protein (mre11)
      cd00840
      Location:14 – 275
      Blast Score: 520
      MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain
      pfam04152
      Location:294 – 461
      Blast Score: 525
      Mre11_DNA_bind; Mre11 DNA-binding presumed domain

    2. NM_005591.3 → NP_005582.1  double-strand break repair protein MRE11A isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform of this protein.
      Source sequence(s)
      AF022778, AP000765, BF574168
      Consensus CDS
      CCDS8299.1
      UniProtKB/Swiss-Prot
      P49959
      Conserved Domains (3) summary
      TIGR00583
      Location:10 – 402
      Blast Score: 1277
      mre11; DNA repair protein (mre11)
      cd00840
      Location:14 – 275
      Blast Score: 522
      MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain
      pfam04152
      Location:294 – 461
      Blast Score: 527
      Mre11_DNA_bind; Mre11 DNA-binding presumed domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p10 Primary Assembly

      Range
      94150466..94227040, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      90216033..90292535, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018922.1 Alternate CHM1_1.0

      Range
      94021217..94097798, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01040029.1 (31047..66341) None
    genomic ABBA01040030.1 None
    genomic AF303395.1 AAK18790.1
    genomic AMYH01003965.1 (279432..356013) None
    genomic AP000765.5 (65907..68723) None
    genomic AP000786.4 None
    genomic AY584241.1 AAS79320.1
    genomic CH471065.1 EAW66930.1
      EAW66931.1
      EAW66932.1
      EAW66933.1
      EAW66934.1
    mRNA AF022778.1 AAD10197.1
    mRNA AF073362.1 AAC36249.1
    mRNA AK095388.1 BAG53039.1
    mRNA AK308318.1 None
    mRNA BC005241.1 AAH05241.1
    mRNA BC017823.1 AAH17823.1
    mRNA BC063458.1 AAH63458.1
    mRNA BF574168.1 None
    mRNA BT006730.1 AAP35376.1
    mRNA U37359.1 AAC78721.1
    other-genetic JF432288.1 ADZ15505.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49959.3 GenPept UniProtKB/Swiss-Prot:P49959

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