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CD200 CD200 molecule [ Homo sapiens (human) ]

Gene ID: 4345, updated on 12-May-2016
Official Symbol
CD200provided by HGNC
Official Full Name
CD200 moleculeprovided by HGNC
Primary source
HGNC:HGNC:7203
See related
Ensembl:ENSG00000091972 MIM:155970; Vega:OTTHUMG00000159248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRC; MOX1; MOX2; OX-2
Summary
This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Orthologs
Location:
3q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (112332347..112362812)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (112051194..112081659)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member C1 Neighboring gene ubiquitination factor E4A (UFD2 homolog, yeast) pseudogene Neighboring gene uncharacterized LOC105374042 Neighboring gene uncharacterized LOC105374041 Neighboring gene uncharacterized LOC105374044

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
 
receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
cell recognition IBA
Inferred from Biological aspect of Ancestor
more info
 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell-cell adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
OX-2 membrane glycoprotein
Names
CD200 antigen
antigen identified by monoclonal antibody MRC OX-2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004196.3NP_001004196.2  OX-2 membrane glycoprotein isoform b

    See identical proteins and their annotated locations for NP_001004196.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate in-frame exon in the 5' coding region, compared to variant 1, that results in an isoform (b) with a longer N-terminus, compared to isoform a.
    Source sequence(s)
    AC112487, AK297194, AL832529, DA773259
    Consensus CDS
    CCDS33818.1
    UniProtKB/Swiss-Prot
    P41217
    Related
    ENSP00000420298, OTTHUMP00000214501, ENST00000473539, OTTHUMT00000354079
    Conserved Domains (2) summary
    cd05846
    Location:69165
    Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
    cl11960
    Location:181253
    Ig; Immunoglobulin domain
  2. NM_001318826.1NP_001305755.1  OX-2 membrane glycoprotein isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon resulting in a distinct 5' UTR and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. Both variants 3 and 5 encode the same protein (isoform c).
    Source sequence(s)
    AC112487, AK312563, AL832529, DA773259
    Conserved Domains (1) summary
    cl11960
    Location:40112
    Ig; Immunoglobulin domain
  3. NM_001318828.1NP_001305757.1  OX-2 membrane glycoprotein isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC112487, AK293399, AL832529, BC022522, DA773259
    UniProtKB/Swiss-Prot
    P41217
    UniProtKB/TrEMBL
    B4DDZ6, F8W7G1
    Conserved Domains (1) summary
    cl11960
    Location:166
    Ig; Immunoglobulin domain
  4. NM_001318830.1NP_001305759.1  OX-2 membrane glycoprotein isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in a shorter isoform (c) with a distinct N-terminus, compared to isoform a. Both variants 3 and 5 encode the same protein (isoform c).
    Source sequence(s)
    AK129797, AL832529, DA773259
    Conserved Domains (1) summary
    cl11960
    Location:40112
    Ig; Immunoglobulin domain
  5. NM_005944.6NP_005935.4  OX-2 membrane glycoprotein isoform a precursor

    See identical proteins and their annotated locations for NP_005935.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AL832529, BC022522, DA544134, DA773259
    Consensus CDS
    CCDS2965.1
    UniProtKB/Swiss-Prot
    P41217
    Related
    ENSP00000312766, OTTHUMP00000214500, ENST00000315711, OTTHUMT00000354078
    Conserved Domains (2) summary
    cd05846
    Location:44140
    Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
    cl11960
    Location:156228
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    112332347..112362812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247485.1XP_005247542.1  

    See identical proteins and their annotated locations for XP_005247542.1

    Conserved Domains (2) summary
    cd05846
    Location:37133
    Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
    cl11960
    Location:149221
    Ig; Immunoglobulin domain
  2. XM_006713648.2XP_006713711.1  

    Conserved Domains (1) summary
    cd05846
    Location:69165
    Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
  3. XM_005247481.3XP_005247538.1  

    Conserved Domains (2) summary
    cd05846
    Location:69165
    Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
    cl11960
    Location:181253
    Ig; Immunoglobulin domain
  4. XM_005247490.1XP_005247547.1  

    Conserved Domains (1) summary
    cl11960
    Location:40112
    Ig; Immunoglobulin domain
  5. XM_005247482.1XP_005247539.1  

    See identical proteins and their annotated locations for XP_005247539.1

    UniProtKB/Swiss-Prot
    P41217
    Conserved Domains (2) summary
    cd05846
    Location:44140
    Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
    cl11960
    Location:156228
    Ig; Immunoglobulin domain
  6. XM_005247488.1XP_005247545.1  

    Conserved Domains (1) summary
    cl11960
    Location:40112
    Ig; Immunoglobulin domain
  7. XM_005247491.1XP_005247548.1  

    Related
    ENSP00000418576, OTTHUMP00000214503, ENST00000498096, OTTHUMT00000354081
    Conserved Domains (1) summary
    cd05846
    Location:44140
    Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
  8. XM_005247489.1XP_005247546.1  

    Conserved Domains (1) summary
    cl11960
    Location:40112
    Ig; Immunoglobulin domain
  9. XM_005247487.1XP_005247544.1  

    Related
    ENSP00000373179, OTTHUMP00000214502, ENST00000383681, OTTHUMT00000354080
    Conserved Domains (1) summary
    cl11960
    Location:166
    Ig; Immunoglobulin domain
  10. XM_005247486.1XP_005247543.1  

    Conserved Domains (1) summary
    cl11960
    Location:166
    Ig; Immunoglobulin domain
  11. XM_011512859.1XP_011511161.1  

    Conserved Domains (1) summary
    cl11960
    Location:65137
    Ig; Immunoglobulin domain
  12. XM_005247484.3XP_005247541.1  

    See identical proteins and their annotated locations for XP_005247541.1

    Conserved Domains (2) summary
    cd05846
    Location:37133
    Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
    cl11960
    Location:149221
    Ig; Immunoglobulin domain

RNA

  1. XR_924144.1 RNA Sequence

  2. XR_924143.1 RNA Sequence

  3. XR_924142.1 RNA Sequence

  4. XR_241493.3 RNA Sequence

    Related
    ENST00000478595, OTTHUMT00000354082

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    112015971..112045683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001004197.1: Suppressed sequence

    Description
    NM_001004197.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.