MOS v-mos Moloney murine sarcoma viral oncogene homolog [Homo sapiens] - Gene

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Summary

Official Symbol: MOSprovided by HGNC
Official Full Name: v-mos Moloney murine sarcoma viral oncogene homologprovided by HGNC
Primary source: HGNC:7199
See related: Ensembl:ENSG00000172680; HPRD:01816; MIM:190060; Vega:OTTHUMG00000164299
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MSV; MGC119962; MGC119963
Summary: MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]

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Genomic context

Location :: 8q11

Sequence :: Chromosome: 8; NC_000008.10 (57025501..57026541, complement)

See MOS in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

among the candidate genes, DNA methylation of MOS may reflect the duration of H. pylori exposure and may be a marker for the development of gastric cancer.
Title: Prediction of the risk for gastric cancer using candidate methylation markers in the non-neoplastic gastric mucosae.
Observational study of gene-disease association. (HuGE Navigator)
Title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
In the absence of p53, Mos knockdown prevents multipolar mitoses and exerts genome-stabilizing effects.
Title: Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.
Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition
Title: Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.
Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation.
Title: Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation.
These results clarify the direct link of the classical Mos-MAPK (mitogen-activated protein kinase) pathway to Erp1 in meiotic arrest of vertebrate oocytes.
Title: A direct link of the Mos-MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus laevis eggs.
the Mos/MAPK pathway is not essential for initiating goldfish oocyte maturation despite its general function as a cytostatic factor (CSF).
Title: The Mos/MAPK pathway is involved in metaphase II arrest as a cytostatic factor but is neither necessary nor sufficient for initiating oocyte maturation in goldfish.
multiple meiotic genes are aberrantly activated during mitotic catastrophe in p53 mutated lymphoma cells after irradiation; the coordinated expression of MOS and REC8 regulate the extent of arrested mitoses and polyploidy
Title: Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Many sequence variants affecting diversity of adult human height.

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Products	Interactant	Other Gene	Source	Pubs	Description
P00540	Q13873	BMPR2	HPRD	PubMed
P00540	Heat shock 70 KD protein 1A	HSPA1A	HPRD	PubMed
P00540	P15172	MYOD1	HPRD	PubMed
BioGRID:110483	BioGRID:110737	MYOD1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: proto-oncogene serine/threonine-protein kinase mos

Names: proto-oncogene serine/threonine-protein kinase mos; c-mos; proto-oncogene c-Mos; oocyte maturation factor mos; oncogene MOS, Moloney murine sarcoma virus

NP_005363.1

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005372.1 → NP_005363.1 proto-oncogene serine/threonine-protein kinase mos

Status: VALIDATED

Source sequence(s)

J00119

Consensus CDS

CCDS6164.1

UniProtKB/Swiss-Prot

P00540

Related

ENSP00000310722, OTTHUMP00000226404, ENST00000311923, OTTHUMT00000378174

Conserved Domains (2) summary

cd00180
Location:66 – 335
Blast Score: 443

PKc; Catalytic domain of Protein Kinases

pfam00069
Location:61 – 335
Blast Score: 544

Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

57025501..57026541, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

52492986..52494026, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC107376.7 (83383..84423)	None
genomic	CH471068.1	EAW86773.1
genomic	J00119.1	AAA52029.1
mRNA	BC069569.1	AAH69569.1
mRNA	BC069590.1	AAH69590.1
mRNA	BC106737.1	AAI06738.1
mRNA	BC106738.1	AAI06739.1
other-genetic	HQ447500.1	ADQ31986.1