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    Doa Darkener of apricot [ Drosophila melanogaster ]

    Gene ID: 43415, updated on 10-May-2012
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    Summary

    Official Symbol
    Doaprovided by Flybase
    Official Full Name
    Darkener of apricotprovided by Flybase
    Primary source
    FLYBASE:FBgn0259220
    Locus tag
    Dmel_CG42320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1658; CG31049; CG33204; CG33553; CG42320; Dmel\CG42320; doa; DOA; DOA/CLK2; l(3)01705; Msu
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    Genomic context

    Location :
    98F1-98F2; 3-99 cM
    Sequence :
    Chromosome: 3R; NT_033777.2 (24713799..24748494)
    See Doa in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene CG33203 gene product from transcript CG33203-RB Neighboring gene CG14527 gene product from transcript CG14527-RA Neighboring gene CG14526 gene product from transcript CG14526-RB Neighboring gene CG11828 gene product from transcript CG11828-RD Neighboring gene CG14521 gene product from transcript CG14521-RA Neighboring gene CG1443 gene product from transcript CG1443-RA Neighboring gene mir-4947 stem loop

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Horn T, et al. Nat Methods, 2011 Apr. PMID 21378980.
    2. Transcriptional networks for alcohol sensitivity in Drosophila melanogaster. Morozova TV, et al. Genetics, 2011 Apr. PMID 21270389.
    3. The role of the Drosophila LAMMER protein kinase DOA in somatic sex determination. Rabinow L, et al. J Genet, 2010 Sep. PMID 20876993.
    4. The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors. Arancio W, et al. Genetics, 2010 May. PMID 20194965.
    5. Drosophila translational elongation factor-1gamma is modified in response to DOA kinase activity and is essential for cellular viability. Fan Y, et al. Genetics, 2010 Jan. PMID 19841092.

    See all (52) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The Doa locus encodes six different kinases, of which a 69-kDa isoform is expressed solely in females.
      Title: The role of the Drosophila LAMMER protein kinase DOA in somatic sex determination.
    2. mutations in the gene protect against the decrease in life span caused by the reactive oxygen species generator paraquat, associated with an increase in cytoplasmic and mitochondrial superoxide dismutase protein levels and activity
      Title: Superoxide dismutase is regulated by LAMMER kinase in Drosophila and human cells.
    3. the roles of the multiple isoforms, we mapped polymorphisms, deletions, and P-element insertions in the locus, identifying several that are largely, if not completely, isoform specific in their effects
      Title: Dissection of darkener of apricot kinase isoform functions in Drosophila.
    4. Alternative promoter usage generates multiple evolutionarily conserved isoforms of Drosophila DOA kinase.
      Title: Alternative promoter usage generates multiple evolutionarily conserved isoforms of Drosophila DOA kinase.
    5. DX16 could be a novel serine-arginine-rich protein phosphorylated by DOA and it may participate in the formation of splicing complex through its interactions with other splicing related proteins.
      Title: DX16 is a novel SR protein phosphorylated by DOA.
    6. DNA mutational analysis was done on Doa - a gene required for oocyte specification and development.
      Title: Identification and analysis of mutations in bob, Doa and eight new genes required for oocyte specification and development in Drosophila melanogaster.
    7. Data indicate that genes encoding proteins involved in closely related pathways are concentrated at certain loci to achieve more efficient regulation of their expression as exemplified from distribution of DOA protein on Drosophila polythene chromosomes.
      Title: Binding of doa kinase to specific loci in polytene chromosomes of Drosophila melanogaster.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:68286 BioGRID:60138 CG11266    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:60093 CG11327    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:59449 CG11555    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:67857 CG13625    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:57563 CG18273    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:66531 CG18476    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:66561 CG31211    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:77508 CG33109    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:65539 CG4858    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:59555 CG4887    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:61084 CG5783    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:62268 CG6191    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:66545 CG6923    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:63595 CG7028    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:63740 CG7971    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:58854 CG8128    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:62961 CG8929    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:65767 CG9776    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:58933 CG9915    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:66550 ClC-a    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:61365 Cul-2    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:60913 Cul-3    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:59685 Cwc25    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:68286 Doa    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:66494 KP78b    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:63381 PHDP    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:72126 Pp1-87B    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:69445 Pp4-19C    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:59266 Ranbp21    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:72731 SC35    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:72730 SF2    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:62049 Sln    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:67915 Smg6    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:60406 Srp54    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:60212 TwdlE    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:64105 Ubp64E    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:68781 cas    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:61353 dimm    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:63438 enok    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:61259 lok    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:59482 lwr    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:64116 mad2    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:62160 muskelin    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:57584 skpA    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:68433 spn-A    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:68659 toy    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:65151 tra    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:68286 BioGRID:62366 tra2    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:65419 verm    BioGRID  PubMed Two-hybrid 
    BioGRID:68286 BioGRID:57802 w    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
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    General gene information

    Markers

    Homology

    • Homologs of the Doa gene: The Doa gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and A.thaliana.

    Pathways from BioSystems

    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' pol...

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein serine/threonine/tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    NOT MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    autophagic cell death IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    blastoderm segmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    blastoderm segmentation NAS
    Non-traceable Author Statement
    more info
    		  
    brain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    central nervous system development NAS
    Non-traceable Author Statement
    more info
    		  
    chaeta morphogenesis NAS
    Non-traceable Author Statement
    more info
    		  
    chitin-based embryonic cuticle biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		  
    compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    compound eye development NAS
    Non-traceable Author Statement
    more info
    		  
    compound eye photoreceptor development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    compound eye photoreceptor development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    compound eye photoreceptor development NAS
    Non-traceable Author Statement
    more info
    		  
    karyosome formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nervous system development NAS
    Non-traceable Author Statement
    more info
    		  
    oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    photoreceptor cell maintenance NAS
    Non-traceable Author Statement
    more info
    		  
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of alternative nuclear mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    salivary gland cell autophagic cell death IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    sex differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    sex differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    startle response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG42320 gene product from transcript CG42320-RJ
    Names
    CG42320-PJ
    CG42320-PK
    CG42320-PL
    CG42320-PM
    CG42320-PN
    CG42320-PP
    CG42320-PQ
    CG42320-PR
    CG42320-PS
    CG42320-PT
    CG42320-PU
    CG42320-PV
    CG42320-PW
    CG42320-PX
    CG42320-PY
    CG42320-PZ
    Doa-PJ
    Doa-PK
    Doa-PL
    Doa-PM
    Doa-PN
    Doa-PP
    Doa-PQ
    Doa-PR
    Doa-PS
    Doa-PT
    Doa-PU
    Doa-PV
    Doa-PW
    Doa-PX
    Doa-PY
    Doa-PZ
    darkener of apricot
    mosaic suppressor
    NP_001014678.1
    NP_001014679.1
    NP_001014680.1
    NP_001014681.2
    NP_001014682.1
    NP_001036763.2
    NP_001036764.2
    NP_001036765.1
    NP_001097961.1
    NP_001138120.1
    NP_001138121.1
    NP_001138122.1
    NP_001163766.1
    NP_001247353.1
    NP_001247354.1
    NP_788758.3
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      24713799..24748494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014680.3 → NP_001014680.1  darkener of apricot, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V3J9
      UniProtKB/Swiss-Prot
      P49762
      Related
      FBpp0289020, FBtr0299742
      Conserved Domains (2) summary
      cd00180
      Location:239 – 451
      Blast Score: 379
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:233 – 547
      Blast Score: 574
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    2. NM_001144648.2 → NP_001138120.1  darkener of apricot, isoform T [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V3J9
      UniProtKB/Swiss-Prot
      P49762
      Related
      FBpp0289027, FBtr0299749
      Conserved Domains (2) summary
      cd00180
      Location:239 – 451
      Blast Score: 379
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:233 – 547
      Blast Score: 574
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    3. NM_001043300.2 → NP_001036765.1  darkener of apricot, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V3J9
      UniProtKB/Swiss-Prot
      P49762
      Related
      FBpp0289023, FBtr0299745
      Conserved Domains (2) summary
      cd00180
      Location:239 – 451
      Blast Score: 379
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:233 – 547
      Blast Score: 574
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    4. NM_001144649.1 → NP_001138121.1  darkener of apricot, isoform U [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V3J9
      UniProtKB/Swiss-Prot
      P49762
      Related
      FBpp0289028, FBtr0299750
      Conserved Domains (2) summary
      cd00180
      Location:239 – 451
      Blast Score: 379
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:233 – 547
      Blast Score: 574
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    5. NM_001043299.3 → NP_001036764.2  darkener of apricot, isoform M [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI03
      Related
      FBpp0289031, FBtr0299753
      Conserved Domains (2) summary
      cd00180
      Location:239 – 451
      Blast Score: 375
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:233 – 547
      Blast Score: 567
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    6. NM_001170295.1 → NP_001163766.1  darkener of apricot, isoform W [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ11
      Related
      FBpp0290610, FBtr0301396
      Conserved Domains (2) summary
      cd00180
      Location:258 – 470
      Blast Score: 375
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:252 – 572
      Blast Score: 565
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    7. NM_001104491.2 → NP_001097961.1  darkener of apricot, isoform Q [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRF7
      Related
      FBpp0289024, FBtr0299746
      Conserved Domains (2) summary
      cd00180
      Location:258 – 470
      Blast Score: 375
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:252 – 566
      Blast Score: 570
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    8. NM_001014682.3 → NP_001014682.1  darkener of apricot, isoform S [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0R6
      UniProtKB/Swiss-Prot
      P49762
      Related
      FBpp0289026, FBtr0299748
      Conserved Domains (2) summary
      cd00180
      Location:170 – 382
      Blast Score: 376
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:164 – 478
      Blast Score: 567
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    9. NM_001144650.1 → NP_001138122.1  darkener of apricot, isoform V [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0R6
      UniProtKB/Swiss-Prot
      P49762
      Related
      FBpp0289030, FBtr0299752
      Conserved Domains (2) summary
      cd00180
      Location:170 – 382
      Blast Score: 376
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:164 – 478
      Blast Score: 567
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    10. NM_001014678.2 → NP_001014678.1  darkener of apricot, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IML9
      Related
      FBpp0289022, FBtr0299744
      Conserved Domains (2) summary
      cd00180
      Location:642 – 854
      Blast Score: 399
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:636 – 950
      Blast Score: 604
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    11. NM_001260424.1 → NP_001247353.1  darkener of apricot, isoform X [Drosophila melanogaster]

      Status: REVIEWED

    12. NM_001014681.4 → NP_001014681.2  darkener of apricot, isoform P [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86B73
      Related
      FBpp0289029
      Conserved Domains (2) summary
      cd00180
      Location:1698 – 1910
      Blast Score: 399
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:1692 – 2012
      Blast Score: 604
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    13. NM_001043298.2 → NP_001036763.2  darkener of apricot, isoform Y [Drosophila melanogaster]

      Status: REVIEWED

    14. NM_001014679.2 → NP_001014679.1  darkener of apricot, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49762
      Related
      FBpp0289021, FBtr0299743
      Conserved Domains (2) summary
      cd00180
      Location:485 – 697
      Blast Score: 380
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:479 – 799
      Blast Score: 577
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    15. NM_176581.4 → NP_788758.3  darkener of apricot, isoform R [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86B72
      Related
      FBpp0289025, FBtr0299747
      Conserved Domains (2) summary
      cd00180
      Location:882 – 1094
      Blast Score: 394
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:876 – 1196
      Blast Score: 592
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    16. NM_001260425.1 → NP_001247354.1  darkener of apricot, isoform Z [Drosophila melanogaster]

      Status: REVIEWED

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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA AY061474.1 AAL29022.1
    genomic AE014297.2 ABI31214.1
    genomic AE014297.2 ACL83576.1
    genomic AE014297.2 ACL83577.1
    genomic AE014297.2 AAF56832.3
    genomic AE014297.2 ABI31213.2
    genomic AE014297.2 ACZ95060.1
    genomic AE014297.2 ABW08797.1
    genomic AE014297.2 ACL83578.1
    genomic AE014297.2 AAF56833.2
    mRNA EF489455.1 ABY60877.1
    genomic AE014297.2 AAN14304.2
    mRNA BT133441.1 AFH78573.1
    genomic AE014297.2 AFH06670.1
    genomic AE014297.2 AAO41610.2
    genomic AE014297.2 ABI31212.2
    genomic AE014297.2 AAN14305.1
    mRNA AY069573.1 AAL39718.1
    genomic AE014297.2 AAO41611.3
    genomic AE014297.2 AFH06671.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAF56832.2 GenPept
    Help top of page

    Additional Links

    Gene LinkOut

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