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MOG myelin oligodendrocyte glycoprotein [ Homo sapiens (human) ]

Gene ID: 4340, updated on 29-Jul-2014
Official Symbol
MOGprovided by HGNC
Official Full Name
myelin oligodendrocyte glycoproteinprovided by HGNC
Primary source
HGNC:7197
Locus tag
DAQB-92E24.2
See related
Ensembl:ENSG00000204655; HPRD:11831; MIM:159465; Vega:OTTHUMG00000031099
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTN6; BTNL11; MOGIG2; NRCLP7
Summary
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Location:
6p22.1
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (29656981..29672372)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (29624758..29640149)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid (GABA) B receptor, 1 Neighboring gene SUMO2 pseudogene 1 Neighboring gene ZFP57 zinc finger protein Neighboring gene zinc finger, DHHC-type containing 20 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Narcolepsy 7
MedGen: C3280266 OMIM: 614250 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC26137

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of MyD88-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
myelin-oligodendrocyte glycoprotein
Names
myelin-oligodendrocyte glycoprotein
MOG Ig-AluB
MOG alpha-5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031873.1 

    Range
    5001..20392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001008228.2NP_001008229.1  myelin-oligodendrocyte glycoprotein isoform alpha3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha3) has multiple differences in the coding region, compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to isoform beta1. The resulting isoform (alpha3) is shorter and contains a shorter and distinct C-terminus, compared to isoform beta1.
    Source sequence(s)
    AL119259, DA139582, DA140757, DA253273, U18843, U64564
    Consensus CDS
    CCDS34369.1
    UniProtKB/Swiss-Prot
    Q16653
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 447
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  2. NM_001008229.2NP_001008230.1  myelin-oligodendrocyte glycoprotein isoform beta2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta2) lacks an in-frame segment of the coding region, compared to variant beta1. It encodes a shorter isoform (beta2), that is missing an internal segment, compared to isoform beta1.
    Source sequence(s)
    AL119259, AY566853, DA139582, DA140757, DA253273, U64564
    Consensus CDS
    CCDS34368.1
    UniProtKB/Swiss-Prot
    Q16653
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 446
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  3. NM_001170418.1NP_001163889.1  myelin-oligodendrocyte glycoprotein isoform alpha6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha6) lacks an alternate in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR, compared to variant beta1. The encoded isoform (alpha6) has a distinct C-terminus and is shorter than isoform beta1.
    Source sequence(s)
    AL119259, AY566847, DA139582, DA140757, DA253273, U64564
    Consensus CDS
    CCDS54977.1
    UniProtKB/Swiss-Prot
    Q16653
  4. NM_002433.4NP_002424.3  myelin-oligodendrocyte glycoprotein isoform beta1 precursor

    See proteins identical to NP_002424.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta1) encodes the longest isoform (beta1), also known as isoform 1.
    Source sequence(s)
    AL119259, AY566852, DA139582, DA140757, DA253273, U64564
    Consensus CDS
    CCDS4667.1
    UniProtKB/Swiss-Prot
    Q16653
    UniProtKB/TrEMBL
    Q5SSB8
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 451
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  5. NM_206809.3NP_996532.2  myelin-oligodendrocyte glycoprotein isoform alpha1 precursor

    See proteins identical to NP_996532.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha1) contains an additional segment in the coding region compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to variant beta1. The resulting isoform (alpha1), also known as isoform 2, contains a shorter and distinct C-terminus compared to isoform beta1.
    Source sequence(s)
    AL119259, DA139582, DA140757, DA253273, U64564, X74511
    Consensus CDS
    CCDS34370.1
    UniProtKB/Swiss-Prot
    Q16653
    Related
    ENSP00000366115, OTTHUMP00000029126, ENST00000376917, OTTHUMT00000076160
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 451
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  6. NM_206810.3NP_996533.2  myelin-oligodendrocyte glycoprotein isoform beta5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta5) lacks an in-frame segment of the coding region, compared to variant beta1. It encodes a shorter isoform (beta5), also known as isoform 3, that is missing an internal segment, compared to isoform beta1.
    Source sequence(s)
    AL119259, DA139582, DA140757, DA253273, U18803, U64564
    Consensus CDS
    CCDS34367.1
    UniProtKB/Swiss-Prot
    Q16653
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 445
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  7. NM_206811.3NP_996534.2  myelin-oligodendrocyte glycoprotein isoform beta3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta3) has multiple differences in the coding region, compared to variant beta1. The resulting isoform (beta3), also known as isoform 4, is shorter, compared to isoform beta1.
    Source sequence(s)
    AL119259, DA139582, DA140757, DA253273, U18840, U64564
    Consensus CDS
    CCDS34366.1
    UniProtKB/Swiss-Prot
    Q16653
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 447
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  8. NM_206812.3NP_996535.2  myelin-oligodendrocyte glycoprotein isoform alpha2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha2) has multiple differences in the coding region, compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to isoform beta1. The resulting isoform (alpha2), also known as isoform 5, is shorter and contains a shorter and distinct C-terminus, compared to isoform beta1.
    Source sequence(s)
    AL119259, DA139582, DA140757, DA253273, U18799, U64564
    Consensus CDS
    CCDS47394.1
    UniProtKB/Swiss-Prot
    Q16653
    Related
    ENSP00000410866, OTTHUMP00000029123, ENST00000431798, OTTHUMT00000076157
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 445
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  9. NM_206814.5NP_996537.3  myelin-oligodendrocyte glycoprotein isoform alpha5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha5) lacks an alternate in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR, compared to variant beta1. The encoded isoform (alpha5) has a distinct C-terminus and is shorter than isoform beta1.
    Source sequence(s)
    AK308949, AL119259, DA139582, DA140757, DA253273, U64564
    Consensus CDS
    CCDS47395.2
    UniProtKB/Swiss-Prot
    Q16653
    Related
    ENSP00000366085, OTTHUMP00000029120, ENST00000376888, OTTHUMT00000076154

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 

    Range
    922690..938080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274865.1XP_005274922.1  

    See proteins identical to XP_005274922.1

    UniProtKB/TrEMBL
    Q8IYG5
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 448
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  2. XM_005274874.1XP_005274931.1  

    See proteins identical to XP_005274931.1

    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 444
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  3. XM_005274875.2XP_005274932.1  

    See proteins identical to XP_005274932.1

    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 444
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like

Reference GRCh38 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 

    Range
    1143453..1158845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272820.1XP_005272877.1  

    See proteins identical to XP_005272877.1

    UniProtKB/TrEMBL
    Q8IYG5
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 448
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  2. XM_005272829.1XP_005272886.1  

    See proteins identical to XP_005272886.1

    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 444
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  3. XM_005272830.2XP_005272887.1  

    See proteins identical to XP_005272887.1

    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 444
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like

Reference GRCh38 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 

    Range
    922526..937918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274977.1XP_005275034.1  

    See proteins identical to XP_005275034.1

    UniProtKB/TrEMBL
    Q8IYG5
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 448
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  2. XM_005274986.1XP_005275043.1  

    See proteins identical to XP_005275043.1

    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 444
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like

Reference GRCh38 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 

    Range
    922098..937486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005275125.1XP_005275182.1  

    See proteins identical to XP_005275182.1

    UniProtKB/TrEMBL
    Q8IYG5
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 448
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  2. XM_005275134.1XP_005275191.1  

    See proteins identical to XP_005275191.1

    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 444
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like

Reference GRCh38 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 

    Range
    922362..937746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005275252.1XP_005275309.1  

    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 449
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  2. XM_005275261.1XP_005275318.1  

    See proteins identical to XP_005275318.1

    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 444
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  3. XM_005275262.2XP_005275319.1  

    See proteins identical to XP_005275319.1

    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 444
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like

Reference GRCh38 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 

    Range
    922481..937873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005275410.1XP_005275467.1  

    See proteins identical to XP_005275467.1

    UniProtKB/TrEMBL
    Q8IYG5
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 448
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  2. XM_005275419.1XP_005275476.1  

    See proteins identical to XP_005275476.1

    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 444
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like

Reference GRCh38 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 

    Range
    966016..981404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005275558.1XP_005275615.1  

    See proteins identical to XP_005275615.1

    UniProtKB/TrEMBL
    Q8IYG5
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 448
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  2. XM_005275567.1XP_005275624.1  

    See proteins identical to XP_005275624.1

    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 444
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  3. XM_005275568.2XP_005275625.1  

    See proteins identical to XP_005275625.1

    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 444
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    29656981..29672372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249131.1XP_005249188.1  

    UniProtKB/TrEMBL
    Q5SUK5
    Related
    ENSP00000366091, OTTHUMP00000109158, ENST00000376894, OTTHUMT00000194941
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 449
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  2. XM_005249139.1XP_005249196.1  

    See proteins identical to XP_005249196.1

    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 444
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like
  3. XM_005249140.1XP_005249197.1  

    See proteins identical to XP_005249197.1

    Conserved Domains (2) summary
    cd05713
    Location:46144
    Blast Score: 444
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    Blast Score: 126
    IG_like; Immunoglobulin like

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    29431836..29447189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    29626856..29642241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_206813.4: Suppressed sequence

    Description
    NM_206813.4: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.