fkh fork head [Drosophila melanogaster (fruit fly)] - Gene

Summary

Go to the top of the page Help

Official Symbol: fkhprovided by FlyBase
Official Full Name: fork headprovided by FlyBase
Primary source: FLYBASE:FBgn0000659
Locus tag: Dmel_CG10002
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10002; dFoxA; Dmel\CG10002; Dmfkh; Fkh; FKH; Sebp2

Genomic context

Go to the top of the page Help

Location :: 98D5-98D5; 3-95 cM

Sequence :: Chromosome: 3R; NT_033777.2 (24406805..24410834, complement)

See fkh in Epigenomics, MapViewer

Chromosome 3R - NT_033777.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin
Title: The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin.
Mapping of potential trithorax-associated regulatory elements within the extended (9 kb) promoter region of the fork head gene (fkh) in the Drosophila melanogaster salivary gland cells was performed.
Title: [Immunoprecipitation mapping of the TRX-associated chromosome elements in the fork head gene promoter in the Drosophila melanogaster salivary gland cells].
Fkh cooperates with the salivary gland-specific bHLH protein Sage to directly regulate expression of PH4alphaSG2, as well as sage itself, and to indirectly regulate expression of PH4alphaSG1.
Title: Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2.
FKH represses trachealess (trh), a duct-specific gene initially expressed throughout the salivary gland primordium.
Title: Specification of cell fates within the salivary gland primordium.
Fkh plays a pivotal role in the normal control of developmental cell death.
Title: Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:68259	BioGRID:66072	CG10032	BioGRID	PubMed	Two-hybrid
BioGRID:68259	BioGRID:70214	CG11899	BioGRID	PubMed	Two-hybrid
BioGRID:68259	BioGRID:68440	CG15529	BioGRID	PubMed	Two-hybrid
BioGRID:68259	BioGRID:64799	CG17666	BioGRID	PubMed	Two-hybrid
BioGRID:68259	BioGRID:76890	CG31054	BioGRID	PubMed	Two-hybrid
BioGRID:68259	BioGRID:72704	CG34168	BioGRID	PubMed	Two-hybrid
BioGRID:68259	BioGRID:78197	CG41099	BioGRID	PubMed	Two-hybrid
BioGRID:68259	BioGRID:68239	CG4849	BioGRID	PubMed	Two-hybrid
BioGRID:68259	BioGRID:59306	CG9572	BioGRID	PubMed	Two-hybrid
BioGRID:68259	BioGRID:58538	CkIIbeta	BioGRID	PubMed	Two-hybrid
BioGRID:68259	BioGRID:66080	Mst84Da	BioGRID	PubMed	Two-hybrid
BioGRID:68259	BioGRID:66078	Mst84Dc	BioGRID	PubMed	Two-hybrid
BioGRID:68259	BioGRID:62692	P32	BioGRID	PubMed	Two-hybrid
BioGRID:68259	BioGRID:64359	Pex2	BioGRID	PubMed	Two-hybrid
BioGRID:68259	BioGRID:64710	byn	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:68259	BioGRID:70663	mus205	BioGRID	PubMed	Two-hybrid
BioGRID:68259	BioGRID:67907	ssh	BioGRID	PubMed	Two-hybrid

Pathways from BioSystems

Go to the top of the page Help

Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of beta-cell development, organism-specific biosystem (from REACTOME)
Regulation of beta-cell development, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of gene expression in beta cells, organism-specific biosystem (from REACTOME)
Regulation of gene expression in beta cells, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Go to the top of the page Help

Homology

Homologs of the fkh gene: The fkh gene is conserved in human, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and mosquito.
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
DNA binding, bending	IBA Inferred from Biological aspect of Ancestor more info
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
protein domain specific binding	IBA Inferred from Biological aspect of Ancestor more info
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
DNA endoreduplication	IMP Inferred from Mutant Phenotype more info
Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info
Malpighian tubule morphogenesis	TAS Traceable Author Statement more info	PubMed
ecdysone-mediated induction of salivary gland cell autophagic cell death	IDA Inferred from Direct Assay more info	PubMed
ectodermal digestive tract development	TAS Traceable Author Statement more info	PubMed
embryo development	IBA Inferred from Biological aspect of Ancestor more info
endoderm formation	TAS Traceable Author Statement more info	PubMed
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info
negative regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info
negative regulation of programmed cell death	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info
negative regulation of transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed
pattern specification process	IBA Inferred from Biological aspect of Ancestor more info
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
regulation of sequence-specific DNA binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
regulation of transcription, DNA-dependent	ISS Inferred from Sequence or Structural Similarity more info
regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info
salivary gland boundary specification	NAS Non-traceable Author Statement more info
salivary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
salivary gland development	NAS Non-traceable Author Statement more info	PubMed
salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
salivary gland morphogenesis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISS Inferred from Sequence or Structural Similarity more info
nucleus	NAS Non-traceable Author Statement more info
transcription factor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: CG10002 gene product from transcript CG10002-RC

Names: CG10002-PA; CG10002-PB; CG10002-PC; fkh-PA; fkh-PB; fkh-PC; fork head; forkhead; secretion enhancer-binding protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.2

Range

24406805..24410834, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001276109.1 → NP_001263038.1 fork head, isoform C [Drosophila melanogaster]

Status: REVIEWED

Related

FBpp0303365, FBtr0330333

Conserved Domains (2) summary

cd00059
Location:210 – 287
Blast Score: 372

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam09354
Location:449 – 497
Blast Score: 106

HNF_C; HNF3 C-terminal domain
NM_001170291.1 → NP_001163762.1 fork head, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JJ07

UniProtKB/Swiss-Prot

P14734

Related

FBpp0289487, FBtr0300259

Conserved Domains (2) summary

cd00059
Location:210 – 287
Blast Score: 371

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam09354
Location:449 – 497
Blast Score: 104

HNF_C; HNF3 C-terminal domain
NM_079818.3 → NP_524542.1 fork head, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JJ07

UniProtKB/Swiss-Prot

P14734

Related

FBpp0084690, FBtr0085321

Conserved Domains (2) summary

cd00059
Location:210 – 287
Blast Score: 371

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam09354
Location:449 – 497
Blast Score: 104

HNF_C; HNF3 C-terminal domain