wdb widerborst [Drosophila melanogaster] - Gene

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Summary

Official Symbol: wdbprovided by Flybase
Official Full Name: widerborstprovided by Flybase
Primary source: FLYBASE:FBgn0027492
Locus tag: Dmel_CG5643
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0318/07; B56-2; BcDNA:LD34343; BEST:LD02456; CG5643; dB56-2; Dmel\CG5643; dPP2A; EP3559; l(3)S031807; LD02456; PP2-AB; PP2a; PP2A; Wdb

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Genomic context

Location :: 98A6-98A8

Sequence :: Chromosome: 3R; NT_033777.2 (23390764..23407961, complement)

See wdb in Epigenomics, MapViewer

Chromosome 3R - NT_033777.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

wdb- and lkb1-dependent lifespan extension is mediated by downregulation of S6K, a downstream component of the insulin/IGF and TOR signaling pathways.
Title: A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila.
The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila
Title: The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila.
posttranslational mechanisms that drive cycling of PER require the rhythmic expression of PP2A (wdb and tws)
Title: Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A.
Planar cell polarization of wing epithelial cells requires Widerborst, a B' regulatory subunit of protein phosphatase 2A.
Title: Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A.
B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster.
Title: B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:68196	BioGRID:67008	Akt1	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:58514	CG11696	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:65853	CG14667	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:62548	CG15710	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:68277	CG1647	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:68397	CG31036	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:607119	CG34109	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:67086	CG3678	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:64646	CG6163	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:62698	CG6424	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:62290	CG6543	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:62344	CG8617	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:64207	CG9948	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:59642	CG9967	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:302275	CSN8	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:65035	CkIIalpha-i1	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:59513	Clp	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:68567	CycG	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:66148	DNApol-iota	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:61336	E2f2	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:65562	Pka-R1	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:77789	Pp2A-29B	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:59332	cactin	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:67428	cdc2c	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:60919	esg	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:63957	fd64A	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:62282	fl(2)d	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:62905	hpo	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:70018	mts	BioGRID	PubMed	Phenotypic Suppression
BioGRID:68196	BioGRID:63585	p130CAS	BioGRID	PubMed	Two-hybrid
BioGRID:68196	BioGRID:77702	par-1	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the wdb gene: The wdb gene is conserved in human, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, and A.thaliana.

Pathways from BioSystems

Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Beta-catenin phosphorylation cascade, organism-specific biosystem (from REACTOME)
Beta-catenin phosphorylation cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CTLA4 inhibitory signaling, organism-specific biosystem (from REACTOME)
CTLA4 inhibitory signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
Costimulation by the CD28 family, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
Degradation of beta-catenin by the destruction complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glycogen Metabolism, organism-specific biosystem (from WikiPathways)
Glycogen Metabolism, organism-specific biosystemGlycogen is a very large, branched polymer of glucose residues. Within skeletal musle and liver glucose is stored as glycogen. In the liver, glycogen synthesis and degradation are regulated to mainta...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Wnt, organism-specific biosystem (from REACTOME)
Signaling by Wnt, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Wnt signaling pathway, organism-specific biosystem (from KEGG)
Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt signaling pathway, conserved biosystem (from KEGG)
Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
mRNA surveillance pathway, organism-specific biosystem (from KEGG)
mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
mRNA surveillance pathway, conserved biosystem (from KEGG)
mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
binding	IEA Inferred from Electronic Annotation more info
protein phosphatase type 2A regulator activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
determination of adult lifespan	IDA Inferred from Direct Assay more info
signal transduction	IEA Inferred from Electronic Annotation more info
spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
protein phosphatase type 2A complex	ISS Inferred from Sequence or Structural Similarity more info

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General protein information

Preferred Names: CG5643 gene product from transcript CG5643-RB

Names: CG5643-PA; CG5643-PB; CG5643-PC; CG5643-PD; CG5643-PE; PP2A B subunit; PP2A regulatory subunit; protein phosphatase 2a; protein phosphatase PP2A; wdb-PA; wdb-PB; wdb-PC; wdb-PD; wdb-PE; widerborst; wiederborst

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.2

Range

23390764..23407961, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170337.2 → NP_733216.1 widerborst, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9VB23

Related

FBpp0084573, FBtr0085203

Conserved Domains (1) summary

cl03277
Location:48 – 424
Blast Score: 1291

B56; Protein phosphatase 2A regulatory B subunit (B56 family)
NM_170338.2 → NP_733217.1 widerborst, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9VB23

Related

FBpp0084574, FBtr0085204

Conserved Domains (1) summary

cl03277
Location:48 – 424
Blast Score: 1291

B56; Protein phosphatase 2A regulatory B subunit (B56 family)
NM_170336.2 → NP_733215.1 widerborst, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9VB23

Related

FBpp0084577, FBtr0085207

Conserved Domains (1) summary

cl03277
Location:48 – 424
Blast Score: 1291

B56; Protein phosphatase 2A regulatory B subunit (B56 family)
NM_143312.3 → NP_651569.1 widerborst, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9VB23

Related

FBpp0084578, FBtr0085208

Conserved Domains (1) summary

cl03277
Location:48 – 424
Blast Score: 1291

B56; Protein phosphatase 2A regulatory B subunit (B56 family)
NM_170339.2 → NP_733218.1 widerborst, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9VB23

Related

FBpp0084579, FBtr0085209

Conserved Domains (1) summary

cl03277
Location:48 – 424
Blast Score: 1291

B56; Protein phosphatase 2A regulatory B subunit (B56 family)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AE014297.2	AAN14114.1
genomic	AE014297.2	AAN14113.1
genomic	AE014297.2	AAN14115.1
genomic	AE014297.2	AAN14116.1
genomic	AE014297.2	AAF56720.2
mRNA	AF145696.1	AAD38671.1