MMP14 matrix metallopeptidase 14 (membrane-inserted) [Homo sapiens] - Gene

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Summary

Official Symbol: MMP14provided by HGNC
Official Full Name: matrix metallopeptidase 14 (membrane-inserted)provided by HGNC
Primary source: HGNC:7160
See related: Ensembl:ENSG00000157227; HPRD:02856; MIM:600754; Vega:OTTHUMG00000028704
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: 1; MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; MT1-MMP; MT-MMP 1
Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 14q11-q12

Sequence :: Chromosome: 14; NC_000014.8 (23305793..23316803)

See MMP14 in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Silencing of MT1-MMP in aged vascular smooth muscle cells results in impaired but not complete inhibition of basal and Est-stimulated increases in MMP-2 activity.
Title: Role of MT1-MMP in estrogen-mediated cellular processes of intimal hyperplasia.
MT1-MMP is involved in extracellular matrix fibronectin turnover and endocytosis.
Title: MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin.
we showed for the first time that MT1-MMP activates matriptase through the cleavage of HAI-1
Title: Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase.
Antibody fragments selected against emopexin domain of MT-MMP could inhibit its activity.
Title: Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domain.
Thus, our findings reveal that MMP14 is necessary to efficiently reduce the physical restraints imposed by collagen-I during branching morphogenesis.
Title: Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening.
We demonstrated cortactin and MT1-MMP expression in ameloblastoma.
Title: Invadopodia proteins, cortactin and membrane type I matrix metalloproteinase (MT1-MMP) are expressed in ameloblastoma.
Results reveal important roles for MT1-MMP phosphorylation and trafficking in both cell signaling and cell invasion.
Title: Phosphorylation of membrane type 1-matrix metalloproteinase (MT1-MMP) and its vesicle-associated membrane protein 7 (VAMP7)-dependent trafficking facilitate cell invasion and migration.
The expression level of MT1-MMP was associated with invasive depth of tumor cells.
Title: [Expression of MT1-MMP and RECK protein in human gastric carcinoma].
MMP-14 activity promotes tumor progression by circumventing apoptosis.
Title: MT1-MMP protects breast carcinoma cells against type I collagen-induced apoptosis.
fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices
Title: Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices.

Submit: New GeneRIF Correction See all (238)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P50281	P16112	ACAN	HPRD	PubMed
P50281	Q9BV57	ADI1	HPRD	PubMed
P50281	Q07021	C1QBP	HPRD	PubMed
P50281	Q03135	CAV1	HPRD	PubMed
P50281	P80098	CCL7	HPRD	PubMed
P50281	O95832	CLDN1	HPRD	PubMed
P50281	P00748	F12	HPRD	PubMed
P50281	P06756	ITGAV	HPRD	PubMed
P50281	Q15726	KISS1	HPRD	PubMed
P50281	Q07954	LRP1	HPRD	PubMed
P50281	P51884	LUM	HPRD	PubMed
P50281	P45452	MMP13	HPRD	PubMed
P50281	P08253	MMP2	HPRD	PubMed
P50281	P18827	SDC1	HPRD	PubMed
P50281	Q08629	SPOCK1	HPRD	PubMed
P50281	Q9BQ16	SPOCK3	HPRD	PubMed
P50281	P16035	TIMP2	HPRD	PubMed
P50281	P35625	TIMP3	HPRD	PubMed
P50281	Q99727	TIMP4	HPRD	PubMed
BioGRID:110466	BioGRID:107169	C1QBP	BioGRID	PubMed	Protein-peptide
BioGRID:110466	BioGRID:110215	LRP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110466	BioGRID:110238	LUM	BioGRID	PubMed	Biochemical Activity
BioGRID:110466	BioGRID:119160	SPOCK3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110466	BioGRID:112933	TIMP2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110466	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
calcium ion binding	IEA Inferred from Electronic Annotation more info
integrin binding	IEA Inferred from Electronic Annotation more info
metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
peptidase activator activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
angiogenesis	IEA Inferred from Electronic Annotation more info
astrocyte cell migration	IEA Inferred from Electronic Annotation more info
branching morphogenesis of a tube	IEA Inferred from Electronic Annotation more info
cell migration	IEA Inferred from Electronic Annotation more info
endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
lung development	IEA Inferred from Electronic Annotation more info
metabolic process	IEA Inferred from Electronic Annotation more info
negative regulation of focal adhesion assembly	IEA Inferred from Electronic Annotation more info
ossification	IEA Inferred from Electronic Annotation more info
ovarian follicle development	IEA Inferred from Electronic Annotation more info
proteolysis	IEA Inferred from Electronic Annotation more info
response to estrogen stimulus	IEA Inferred from Electronic Annotation more info
response to hormone stimulus	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
response to oxidative stress	IEA Inferred from Electronic Annotation more info
tissue remodeling	IEA Inferred from Electronic Annotation more info
zymogen activation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
extracellular matrix	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
melanosome	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: matrix metalloproteinase-14

Names: matrix metalloproteinase-14; membrane type 1 metalloprotease; membrane-type matrix metalloproteinase 1; membrane-type-1 matrix metalloproteinase; matrix metalloproteinase 14 (membrane-inserted)

NP_004986.1

EC 3.4.24.80

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004995.2 → NP_004986.1 matrix metalloproteinase-14 preproprotein

Status: REVIEWED

Source sequence(s)

AF158733, Z48481

Consensus CDS

CCDS9577.1

UniProtKB/Swiss-Prot

P50281

Related

ENSP00000308208, OTTHUMP00000027917, ENST00000311852, OTTHUMT00000071660

Conserved Domains (4) summary

cd00094
Location:316 – 508
Blast Score: 500

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:118 – 284
Blast Score: 573

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam11857
Location:560 – 582
Blast Score: 136

DUF3377; Domain of unknown function (DUF3377)

cl15437
Location:36 – 88
Blast Score: 140

PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

23305793..23316803

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

3422973..3433980

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB011056.1	BAC53889.1
genomic	AF158733.1	AAF24178.1
genomic	AL135998.6 (57590..68600)	None
genomic	AY795074.1	AAV40837.1
genomic	CH471078.2	EAW66236.1
		EAW66237.1
mRNA	AK291325.1	BAF84014.1
mRNA	AK312657.1	BAG35540.1
mRNA	BC039581.1	None
mRNA	BC064803.1	AAH64803.1
mRNA	D26512.1	BAA05519.1
mRNA	U41078.1	AAA83770.1
mRNA	X83535.1	CAA58519.1
mRNA	X90925.1	CAA62432.1
mRNA	Z48481.1	CAA88372.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P50281.3	GenPept	UniProtKB/Swiss-Prot:P50281
Q8IXG1	GenPept	UniProtKB/TrEMBL:Q8IXG1
Q9UHK5	GenPept	UniProtKB/TrEMBL:Q9UHK5