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boss bride of sevenless [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43146, updated on 11-Apr-2024

Summary

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Official Symbol
bossprovided by FlyBase
Official Full Name
bride of sevenlessprovided by FlyBase
Primary source
FLYBASE:FBgn0000206
Locus tag
Dmel_CG8285
See related
AllianceGenome:FB:FBgn0000206
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Bos; Boss; BOSS; CG8285; Dmel\CG8285; F; X55887
Summary
Enables receptor ligand activity and sevenless binding activity. Involved in several processes, including compound eye photoreceptor cell differentiation; germ-line stem-cell niche homeostasis; and glucose homeostasis. Located in rhabdomere microvillus membrane. Is integral component of plasma membrane. Is expressed in several structures, including embryonic/larval fat body; imaginal disc; ocellus; primordial germ cell; and retina. Orthologous to several human genes including GPRC5A (G protein-coupled receptor class C group 5 member A); GPRC5B (G protein-coupled receptor class C group 5 member B); and GPRC5C (G protein-coupled receptor class C group 5 member C). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See boss in Genome Data Viewer
Location:
96F8-96F8; 3-89 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25961994..25966948)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21787716..21792670)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR34024 Neighboring gene Crustacean cardioactive peptide receptor Neighboring gene uncharacterized protein Neighboring gene fire dancer Neighboring gene Neurofibromin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila 7-pass transmembrane glycoprotein BOSS and metabolic regulation: What Drosophila can teach us about human energy metabolism. Kohyama-Koganeya A, et al. Methods Enzymol, 2010. PMID 20816226
  2. Cell-cell interaction in the Drosophila retina: the bride of sevenless gene is required in photoreceptor cell R8 for R7 cell development. Reinke R, et al. Cell, 1988 Oct 21. PMID 3167983
  3. Fast co-evolution of sevenless and bride of sevenless in endopterygote insects. Bao R, et al. Dev Genes Evol, 2008 Apr. PMID 18392882
  4. Sevenless and its bride: a marriage of molecules? Tomlinson A. Curr Biol, 1991 Jun. PMID 15336144
  5. Neurobiology. Turning attraction into repulsion. Pasquale E. Science, 2000 Aug 25. PMID 10979856

See all (306) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BOSS affects lifespan by modulating the expression of a set of genes related to oxidative stress resistance and mitochondrial homeostasis
    Title: Loss of BOSS Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila.
  2. summary of the utility of Drosophila as a model organism for studying conserved mechanisms of glucose and triacylglycerol (energy) homeostatic metabolism through the 7-pass transmembrane glycoprotein BOSS, which carries N-linked carbohydrates.
    Title: The Drosophila 7-pass transmembrane glycoprotein BOSS and metabolic regulation: What Drosophila can teach us about human energy metabolism.
  3. BOSS, responds to extracellular glucose and regulates sugar and lipid metabolism.
    Title: A Drosophila orphan G protein-coupled receptor BOSS functions as a glucose-responding receptor: loss of boss causes abnormal energy metabolism.
  4. Possibility of conserved Sevenless signaling controlled patterning processes in endopterygote insects.
    Title: Fast co-evolution of sevenless and bride of sevenless in endopterygote insects.
  5. Sev is activated by a ligand, Bride of sevenless (Boss), which is expressed by the germline, to prevent ectopic niche differentiation in the posterior gonadal somatic cells
    Title: Boss/Sev signaling from germline to soma restricts germline-stem-cell-niche formation in the anterior region of Drosophila male gonads.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sevenless binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sevenless binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in R7 cell fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in R8 cell-mediated photoreceptor organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-line stem-cell niche homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to glucose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sevenless signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sevenless signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sevenless signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rhabdomere microvillus membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bride of sevenless
Names
CG8285-PA
F transcript
boss-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25961994..25966948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080709.3 → NP_542440.1  bride of sevenless [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_542440.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P22815, Q9VBJ5
    UniProtKB/TrEMBL
    C4XVJ6, Q8MSJ2
    Related
    FBpp0084323, FBtr0084949
    Conserved Domains (1) summary
    pfam00003
    Location:692 → 779
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22815.3 P22815
Q24265 Q24265
Q8MSJ2 Q8MSJ2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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