MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) [Homo sapiens] - Gene

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Summary

Official Symbol: MMP3provided by HGNC
Official Full Name: matrix metallopeptidase 3 (stromelysin 1, progelatinase)provided by HGNC
Primary source: HGNC:7173
See related: Ensembl:ENSG00000149968; HPRD:01703; MIM:185250; Vega:OTTHUMG00000048254
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SL-1; STMY; STR1; CHDS6; MMP-3; STMY1; MGC126102; MGC126103; MGC126104
Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 11q22.3

Sequence :: Chromosome: 11; NC_000011.9 (102706528..102714342, complement)

See MMP3 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TNF-alpha +488 guanine/adenosine variant is an important risk factor for ischemic stroke in South Indians from Andhra Pradesh, whereas MMP-3-1612 5A/6A polymorphism is not associated with stroke in the same population.
Title: Association of tumor necrosis factor-α and matrix metalloproteinase-3 gene variants with stroke.
several closely linked polymorphisms in the MMP-1-MMP-3 loci have an important role in determining the circulating levels of these MMPs in RA, and that MMP-3 polymorphism is associated with the level of disease activity over time.
Title: Influence of variations across the MMP-1 and -3 genes on the serum levels of MMP-1 and -3 and disease activity in rheumatoid arthritis.
Co-expression of SOX2 and MMP-3 may serve as a functionally relevant biomarker for invasive melanoma cells.
Title: SOX2 contributes to melanoma cell invasion.
SPARC was upregulated in pterygium and may collaborate with increased MMP-3 in some patients to account for many of the phenotypic properties characteristic of pterygium.
Title: Involvement of SPARC and MMP-3 in the pathogenesis of human pterygium.
Hc, even in patients with mild hyperhomocysteinaemia, is involved in the pathophysiology of ascending aorta aneurysms, through the regulation of MMP-3 and MMP-9 activity.
Title: Homocysteine and metalloprotease-3 and -9 in patients with ascending aorta aneurysms.
UVA-activated synthesis of metalloproteinases 1, 3 and 9 is prevented by a broad-spectrum sunscreen.
Title: UVA-activated synthesis of metalloproteinases 1, 3 and 9 is prevented by a broad-spectrum sunscreen.
CypA promotes HCC cell metastasis at least partially through up-regulation of MMP3 and MMP9
Title: Cyclophilin A promotes human hepatocellular carcinoma cell metastasis via regulation of MMP3 and MMP9.
5A/5A genotype of MMP-3, the periodontitis patients presented higher frequency of 55% than the control 40%. genotype and serum expression of inflammatory mediators that may be a good bio-marker for diagnosis and prognosis of the periodontitis.
Title: Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis.
found stimulated expression of MMP-1 (3.2-fold expression) and MMP-3 (334-fold expression) in HCMV strain DC-134-infected aortic smooth muscle cells at 72 h following infection
Title: Human cytomegalovirus induces MMP-1 and MMP-3 expression in aortic smooth muscle cells.
genetic variations are associated with increased risk of ulcerative colitis in Caucasians of New Zealand
Title: Genetic variations in matrix metalloproteinases may be associated with increased risk of ulcerative colitis.

Submit: New GeneRIF Correction See all (286)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Coronary heart disease, susceptibility to, 6

MIM: 614466

Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels.

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	CXCR4-tropic and CXCR4/CCR5 dual-tropic HIV-1 gp120 induce the cleavage of CD62 ligand by a mechanism dependent on matrix metalloproteinases 1 and 3, CD4, CXCR4, Galpha(i), and p38 MAPK, whereas CCR5-tropic gp120 does not	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
P08254	P16112	ACAN	HPRD	PubMed
P08254	Q96GW7	BCAN	HPRD	PubMed
P08254	Q99616	CCL13	HPRD	PubMed
P08254	P13500	CCL2	HPRD	PubMed
P08254	P80098	CCL7	HPRD	PubMed
P08254	P80075	CCL8	HPRD	PubMed
P08254	P07585	DCN	HPRD	PubMed
P08254	P10915	HAPLN1	HPRD	PubMed
P08254	P17936	IGFBP3	HPRD	PubMed
P08254	P08254	MMP3	HPRD	PubMed
P08254	P00747	PLG	HPRD	PubMed
P08254	P05121	SERPINE1	HPRD	PubMed
P08254	Q08629	SPOCK1	HPRD	PubMed
P08254	Q9BQ16	SPOCK3	HPRD	PubMed
P08254	P10451	SPP1	HPRD	PubMed
P08254	P01033	TIMP1	HPRD	PubMed
P08254	P35625	TIMP3	HPRD	PubMed
P08254	O14788	TNFSF11	HPRD	PubMed
BioGRID:110458	BioGRID:121964	BCAN	BioGRID	PubMed	Biochemical Activity
BioGRID:110458	BioGRID:119160	SPOCK3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110458	BioGRID:112932	TIMP1	BioGRID	PubMed	Co-crystal Structure

Function	Evidence Code	Pubs
calcium ion binding	IEA Inferred from Electronic Annotation more info
metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
peptidase activity	IEA Inferred from Electronic Annotation more info
protein complex binding	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
cellular response to cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
collagen catabolic process	IEA Inferred from Electronic Annotation more info
female pregnancy	IEA Inferred from Electronic Annotation more info
metabolic process	IEA Inferred from Electronic Annotation more info
proteolysis	IEA Inferred from Electronic Annotation more info
response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to interleukin-1	IEA Inferred from Electronic Annotation more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
wound healing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell body	IEA Inferred from Electronic Annotation more info
dendrite	IEA Inferred from Electronic Annotation more info
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IEA Inferred from Electronic Annotation more info
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
protein complex	IEA Inferred from Electronic Annotation more info
proteinaceous extracellular matrix	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: stromelysin-1

Names: stromelysin-1; transin-1; proteoglycanase; matrix metalloproteinase-3; matrix metalloproteinase 3 (stromelysin 1, progelatinase)

NP_002413.1

EC 3.4.24.17

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012100.1 RefSeqGene

Range

5001..12815

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002422.3 → NP_002413.1 stromelysin-1 preproprotein

Status: REVIEWED

Source sequence(s)

AI628953, AK223291, AP000789, BC074815

Consensus CDS

CCDS8323.1

UniProtKB/Swiss-Prot

P08254

Related

ENSP00000299855, OTTHUMP00000045949, ENST00000299855, OTTHUMT00000109758

Conserved Domains (3) summary

cd00094
Location:289 – 477
Blast Score: 553

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:108 – 264
Blast Score: 585

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

cl15437
Location:25 – 87
Blast Score: 132

PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p5 Primary Assembly

Range

102706528..102714342, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

98634450..98642264, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF405705.1	AAK95247.1
genomic	AP000789.5 (11826..11845)	None
genomic	CH471065.1	EAW67032.1
genomic	J04732.1	AAN86644.1
genomic	M30460.1	AAO65616.1
genomic	U51914.1	None
genomic	U78045.1	AAB36942.1
mRNA	AI628953.1	None
mRNA	AK223283.1	BAD97003.1
mRNA	AK223291.1	BAD97011.1
mRNA	AK313310.1	BAG36115.1
mRNA	BC069676.1	AAH69676.1
mRNA	BC069716.1	AAH69716.1
mRNA	BC074815.2	AAH74815.1
mRNA	BC074869.2	AAH74869.1
mRNA	BC105954.1	AAI05955.1
mRNA	BC107490.1	AAI07491.1
mRNA	BC107491.1	AAI07492.1
mRNA	DQ399598.1	ABD92797.1
mRNA	J03209.1	AAA36321.1
mRNA	X05232.1	CAA28859.1
other-genetic	HQ447430.1	ADQ31916.1