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    MMP1 matrix metallopeptidase 1 (interstitial collagenase) [ Homo sapiens ]

    Gene ID: 4312, updated on 20-May-2012
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    Summary

    Official Symbol
    MMP1provided by HGNC
    Official Full Name
    matrix metallopeptidase 1 (interstitial collagenase)provided by HGNC
    Primary source
    HGNC:7155
    See related
    Ensembl:ENSG00000196611; HPRD:00384; MIM:120353; Vega:OTTHUMG00000048192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLG; CLGN
    Summary
    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
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    Genomic context

    Location :
    11q22.3
    Sequence :
    Chromosome: 11; NC_000011.9 (102660641..102668966, complement)
    See MMP1 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 1-like Neighboring gene spastic ataxia of Charlevoix-Saguenay (sacsin) pseudogene Neighboring gene matrix metallopeptidase 10 (stromelysin 2) Neighboring gene Wilms tumor 1 associated protein pseudogene Neighboring gene casein kinase 1, alpha 1 pseudogene 2 Neighboring gene matrix metallopeptidase 3 (stromelysin 1, progelatinase)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Up-regulation of matrix metalloproteinase-1 and interleukin-6 expression in cocultures of corneal fibroblasts and neural cells. Ko JA, et al. Biochem Biophys Res Commun, 2012 Mar 16. PMID 22369948.
    2. Human cytomegalovirus induces MMP-1 and MMP-3 expression in aortic smooth muscle cells. Prochnau D, et al. Acta Microbiol Immunol Hung, 2011 Dec. PMID 22207289.
    3. [Molecular genetic studies in occupational medicine]. Izmerov NF, et al. Gig Sanit, 2011 Sep-Oct. PMID 22184992.
    4. [Expression of genes for metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis]. Starodubtseva NL, et al. Genetika, 2011 Sep. PMID 22117411.
    5. UVA-activated synthesis of metalloproteinases 1, 3 and 9 is prevented by a broad-spectrum sunscreen. Jean C, et al. Photodermatol Photoimmunol Photomed, 2011 Dec. PMID 22092736.

    See all (593) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. several closely linked polymorphisms in the MMP-1-MMP-3 loci have an important role in determining the circulating levels of these MMPs in RA, and that MMP-3 polymorphism is associated with the level of disease activity over time.
      Title: Influence of variations across the MMP-1 and -3 genes on the serum levels of MMP-1 and -3 and disease activity in rheumatoid arthritis.
    2. MMP-9, MMP-13 and TIMP-1 expression may serve as a prognostic marker for early tumor invasiveness. Moreover, up-regulation of TIMP-1 in tumor and/or surrounding stromal cells may indicate an increased risk for BCC recurrence.
      Title: Expression of matrix metalloproteinase-1, -9, -13, and tissue inhibitor of metalloproteinases-1 in basal cell carcinomas of the eyelid.
    3. Kaplan-Meier survival curves constructed according to MMP1 genotypes showed a more favorable outcome of TAA (log-rank P=0.0146) in subjects with the G allele of rs514921.
      Title: Association of a matrix metallopeptidase 1 gene polymorphism with long-term outcome of thoracic aortic aneurysm.
    4. High concentration of PRP induced an up-regulation of type I collagen, MMP-1, and MMP-2 expression in HSF.
      Title: Platelet-rich plasma induces increased expression of G1 cell cycle regulators, type I collagen, and matrix metalloproteinase-1 in human skin fibroblasts.
    5. the expression of both MMP-1 and IL- 6 was up-regulated in cocultures of corneal fibroblasts and PC12 cells compared with that in cultures of corneal fibroblasts alone.
      Title: Up-regulation of matrix metalloproteinase-1 and interleukin-6 expression in cocultures of corneal fibroblasts and neural cells.
    6. tension-stimulated expression of COL I and MMP-1 is controlled by the ERK/JNK-AP-1 and ERK-NF-kappaB signaling pathways in periodontal ligament fibroblasts
      Title: Involvement of JNK-AP-1 and ERK-NF-κB signaling in tension-stimulated expression of type I collagen and MMP-1 in human periodontal ligament fibroblasts.
    7. activated platelets may be a major source of MMP-1 and to a minor extent MMP-2, in peripheral blood.
      Title: Release of matrix metalloproteinases-1 and -2, but not -9, from activated platelets measured by enzyme-linked immunosorbent assay.
    8. A single nucleotide polymorphism in the MMP1 gene significantly differed between cases and controls only when stratified by smoking status. Minor allele frequency was higher in control women who smoked than in women with endometriosis who smoked.
      Title: A novel gene-environment interaction involved in endometriosis.
    9. Pre-treatment of HaCaT cells with Saponins from Platycodon grandiflorum roots inhibited UVA-induced production of MMP-1 and MMP-9.
      Title: Saponins from the roots of Platycodon grandiflorum suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and NF-κB/AP-1-dependent signaling in HaCaT cells.
    10. Our study showed also that both tumoural and stromal MMP-1 expression is associated with breast tumour progression and poor prognosis.
      Title: MMP-1 expression has an independent prognostic value in breast cancer.
    Submit: New GeneRIF Correction See all (434)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    COPD, rate of decline of lung function in

    Epidermolysis bullosa dystrophica, autosomal recessive, modifier of

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env CXCR4-tropic and CXCR4/CCR5 dual-tropic HIV-1 gp120 induce the cleavage of CD62 ligand by a mechanism dependent on matrix metalloproteinases 1 and 3, CD4, CXCR4, Galpha(i), and p38 MAPK, whereas CCR5-tropic gp120 does not PubMed
    Tat tat HIV-1 Tat and methamphetamine enhance the release of MMP-1, MMP-2, and uPA from human brain cells PubMed
    tat MMP-1 can degrade HIV-1 Tat and this effect is blocked by MMP-1 inhibitors. PubMed
    tat Through the activation of membrane-type-1-matrix-metalloproteinase (MMP-1) and the induction of tissue inhibitor of metalloproteinase-2 (TIMP-2), HIV-1 Tat and bFGF synergize to upregulate MMP-2 secretion and activation in endothelial cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002412.1 NP_001983.1 F2R    BIND  PubMed MMP-1 interacts with PAR1. 
    P03956 P16112 ACAN    HPRD  PubMed  
    P03956 Q96GW7 BCAN    HPRD  PubMed  
    P03956 P35613 BSG    HPRD  PubMed  
    P03956 Q99616 CCL13    HPRD  PubMed  
    P03956 P13500 CCL2    HPRD  PubMed  
    P03956 P80098 CCL7    HPRD  PubMed  
    P03956 P16070 CD44    HPRD  PubMed  
    P03956 P23946 CMA1    HPRD  PubMed  
    P03956 P02458 COL2A1    HPRD  PubMed  
    P03956 P17936 IGFBP3    HPRD  PubMed  
    P03956 P17301 ITGA2    HPRD  PubMed  
    P03956 P09237 MMP7    HPRD  PubMed  
    P03956 P01011 SERPINA3    HPRD  PubMed  
    P03956 P10646 TFPI    HPRD  PubMed  
    P03956 P01033 TIMP1    HPRD  PubMed  
    P03956 O14788 TNFSF11    HPRD  PubMed  
    BioGRID:110456 BioGRID:121964 BCAN    BioGRID  PubMed Biochemical Activity 
    BioGRID:110456 BioGRID:107147 BSG    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110456 BioGRID:109880 ITGA2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110456 BioGRID:112932 TIMP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110456 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of Matrix Metalloproteinases, organism-specific biosystem (from REACTOME)
      Activation of Matrix Metalloproteinases, organism-specific biosystemThe matrix metalloproteinases (MMPs), previously known as matrixins, are classically known to be involved in the turnover of extracellular matrix (ECM) components. However, recent high throughput pro...
    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Basigin interactions, organism-specific biosystem (from REACTOME)
      Basigin interactions, organism-specific biosystemBasigin is a widely expressed transmembrane glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of epithelial cells. Basigin is involved in intercellular interaction...
    • Bladder cancer, organism-specific biosystem (from KEGG)
      Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, conserved biosystem (from KEGG)
      Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
      Degradation of the extracellular matrix, organism-specific biosystemMatrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the...
    • Diabetes pathways, organism-specific biosystem (from REACTOME)
      Diabetes pathways, organism-specific biosystemThis module groups several normal processes that have key roles in the synthesis and function of insulin, insulin-like growth factors and ghrelin, and whose derangement is thus central to the pathoge...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Endothelins, organism-specific biosystem (from Pathway Interaction Database)
      Endothelins, organism-specific biosystem
      Endothelins
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen and elastin embedded in a viscoelastic gel of anionic proteoglycan poly...
    • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
      Glucocorticoid receptor regulatory network, organism-specific biosystem
      Glucocorticoid receptor regulatory network
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Matrix Metalloproteinases, organism-specific biosystem (from WikiPathways)
      Matrix Metalloproteinases, organism-specific biosystemMatrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzi...
    • PPAR signaling pathway, organism-specific biosystem (from KEGG)
      PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPAR signaling pathway, conserved biosystem (from KEGG)
      PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystem (from REACTOME)
      Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystemThe family of Insulin like Growth Factor Binding Proteins (IGFBPs) share 50% amino acid identity with conserved N terminal and C terminal regions responsible for binding Insulin like Growth Factors I...
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Syndecan-1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-1-mediated signaling events, organism-specific biosystem
      Syndecan-1-mediated signaling events
    • Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem (from Pathway Interaction Database)
      Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem
      Validated transcriptional targets of AP1 family members Fra1 and Fra2

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    leukocyte migration TAS
    Traceable Author Statement
    more info
    		  
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
    		  
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    interstitial collagenase
    Names
    interstitial collagenase
    fibroblast collagenase
    matrix metalloprotease 1
    matrix metalloproteinase 1
    NP_001139410.1
    NP_002412.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011740.1 RefSeqGene

      Range
      5001..13326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145938.1 → NP_001139410.1  interstitial collagenase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK297723, AP000619
      UniProtKB/TrEMBL
      B4DN15
      Conserved Domains (3) summary
      cd00094
      Location:209 – 400
      Blast Score: 580
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:42 – 195
      Blast Score: 549
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      cl15437
      Location:1 – 21
      Blast Score: 97
      PG_binding_1; Putative peptidoglycan binding domain

    2. NM_002421.3 → NP_002412.1  interstitial collagenase isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK223036, AP000619, BC013875, DC385245
      Consensus CDS
      CCDS8322.1
      UniProtKB/Swiss-Prot
      P03956
      UniProtKB/TrEMBL
      Q53G95
      Related
      ENSP00000322788, OTTHUMP00000045866, ENST00000315274, OTTHUMT00000109632
      Conserved Domains (3) summary
      cd00094
      Location:275 – 466
      Blast Score: 586
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:108 – 261
      Blast Score: 554
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      cl15437
      Location:27 – 87
      Blast Score: 146
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      102660641..102668966, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      98588616..98596940, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AJ002550.1 None
    genomic AP000619.5 (41437..49762) None
    genomic AY769434.1 AAV28732.1
    genomic CH471065.1 EAW67031.1
    genomic M16567.1 AAA52033.1
    genomic U78045.1 AAB36941.1
    mRNA AK024818.1 None
    mRNA AK098450.1 None
    mRNA AK130687.1 None
    mRNA AK223034.1 BAD96754.1
    mRNA AK223035.1 BAD96755.1
    mRNA AK223036.1 BAD96756.1
    mRNA AK223056.1 BAD96776.1
    mRNA AK223281.1 BAD97001.1
    mRNA AK225495.1 None
    mRNA AK297723.1 BAG60077.1
    mRNA AK301340.1 BAG62888.1
    mRNA BC013118.1 AAH13118.1
    mRNA BC013875.2 AAH13875.1
    mRNA BT006874.1 AAP35520.1
    mRNA BT020147.1 AAV38949.1
    mRNA DC385245.1 None
    mRNA DQ399597.1 ABD92796.1
    mRNA M13509.1 AAA35699.1
    mRNA M15996.1 AAA35700.1
    mRNA X05231.1 CAA28858.1
    mRNA X54925.1 CAA38691.1
    other-genetic DQ890729.2 ABM81655.1
    other-genetic DQ893904.2 ABM84830.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P03956.3 GenPept UniProtKB/Swiss-Prot:P03956
    Q53FK3 GenPept UniProtKB/TrEMBL:Q53FK3
    Q53G75 GenPept UniProtKB/TrEMBL:Q53G75
    Q53G95 GenPept UniProtKB/TrEMBL:Q53G95
    Q53G96 GenPept UniProtKB/TrEMBL:Q53G96
    Q53G97 GenPept UniProtKB/TrEMBL:Q53G97
    Q5TZP0 GenPept UniProtKB/TrEMBL:Q5TZP0
    Q96DZ4 GenPept UniProtKB/TrEMBL:Q96DZ4
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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