These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_029689.1 RefSeqGene
- Range
- 5001..150030
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001040000.2 → NP_001035089.1 afadin isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) has several differences, including the presence of an in-frame coding exon, and the absence of several coding exons from the 3' end compared to variant 1. This results in an isoform (2) with a different and shorter C-terminus compared to isoform 1.
- Source sequence(s)
-
AB209420, AI271860, AK055689, BE503462, D60168
- Consensus CDS
-
CCDS47517.1
- UniProtKB/Swiss-Prot
-
P55196
- Related
- ENSP00000375956, OTTHUMP00000223317, ENST00000392108, OTTHUMT00000372078
- Conserved Domains (5) summary
-
- cd00060
Location:410 – 499
Blast Score: 113
- FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
- cd00992
Location:1007 – 1090
Blast Score: 173
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd01781
Location:247 – 346
Blast Score: 455
- AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
- cd01782
Location:20 – 131
Blast Score: 561
- AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
- pfam01843
Location:785 – 891
Blast Score: 297
- DIL; DIL domain
-
NM_001207008.1 → NP_001193937.1 afadin isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longer isoform (1, also known as AF6i3). This isoform, which contains a C-terminal F-actin-binding site, has been shown to be involved in the regulation of epithelial wound closure and intercellular adhesion (PMID:16882694).
- Source sequence(s)
-
AB209420, AL049698, AL161973, BE645141, DA200453, DB079271
- UniProtKB/Swiss-Prot
-
P55196
- Related
- ENSP00000375960, ENST00000392112
- Conserved Domains (5) summary
-
- cd00060
Location:383 – 483
Blast Score: 116
- FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
- cd00992
Location:991 – 1073
Blast Score: 110
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd01781
Location:246 – 345
Blast Score: 453
- AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
- cd01782
Location:20 – 131
Blast Score: 559
- AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
- pfam01843
Location:769 – 875
Blast Score: 298
- DIL; DIL domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000006.11 Reference GRCh37.p5 Primary Assembly
- Range
- 168227671..168372700
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000138.1 Alternate HuRef
- Range
- 165693043..165800385
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the cited
reason(s). Suppressed RefSeqs do not appear in BLAST databases, related sequence links,
or BLAST links (BLink), but may still be retrieved by clicking on their
accession.version below.
-
NM_001040001.1: Suppressed sequence
- Description
- NM_001040001.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
-
NM_005936.2: Suppressed sequence
- Description
- NM_005936.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.