These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_027813.1 RefSeqGene
- Range
- 5001..95335
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001197104.1 → NP_001184033.1 histone-lysine N-methyltransferase MLL isoform 1 precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
- Source sequence(s)
-
AP000941, AP001267, BC065385, D14540, L04731
- Consensus CDS
-
CCDS55791.1
- UniProtKB/TrEMBL
-
E9PQG7
- UniProtKB/Swiss-Prot
-
Q03164
- Related
- ENSP00000436786, OTTHUMP00000232648, ENST00000534358, OTTHUMT00000389228
- Conserved Domains (8) summary
-
- cd05493
Location:1650 – 1780
Blast Score: 440
- Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
- smart00508
Location:3956 – 3972
Blast Score: 90
- PostSET; Cysteine-rich motif following a subset of SET domains
- cl02650
Location:2026 – 2076
Blast Score: 185
- FYRN; F/Y-rich N-terminus
- cl02651
Location:3672 – 3755
Blast Score: 301
- FYRC; F/Y rich C-terminus
- pfam02008
Location:1148 – 1194
Blast Score: 222
- zf-CXXC; CXXC zinc finger domain
- pfam13771
Location:1903 – 1981
Blast Score: 277
- zf-HC5HC2H; PHD-like zinc-binding domain
- cl02566
Location:3834 – 3954
Blast Score: 415
- SET; SET domain
- cl15348
Location:1568 – 1630
Blast Score: 133
- RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
-
NM_005933.3 → NP_005924.2 histone-lysine N-methyltransferase MLL isoform 2 precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
- Source sequence(s)
-
AB209508, AP000941, AP001267, BC065385, D14540
- Consensus CDS
-
CCDS31686.1
- UniProtKB/Swiss-Prot
-
Q03164
- Related
- ENSP00000374157, OTTHUMP00000238461, ENST00000389506, OTTHUMT00000399085
- Conserved Domains (8) summary
-
- cd05493
Location:1647 – 1777
Blast Score: 440
- Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
- smart00508
Location:3953 – 3969
Blast Score: 90
- PostSET; Cysteine-rich motif following a subset of SET domains
- cl02650
Location:2023 – 2073
Blast Score: 185
- FYRN; F/Y-rich N-terminus
- cl02651
Location:3669 – 3752
Blast Score: 301
- FYRC; F/Y rich C-terminus
- pfam02008
Location:1148 – 1194
Blast Score: 222
- zf-CXXC; CXXC zinc finger domain
- pfam13771
Location:1900 – 1978
Blast Score: 277
- zf-HC5HC2H; PHD-like zinc-binding domain
- cl02566
Location:3831 – 3951
Blast Score: 415
- SET; SET domain
- cl15348
Location:1568 – 1627
Blast Score: 147
- RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000011.9 Reference GRCh37.p5 Primary Assembly
- Range
- 118307205..118397539
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000143.1 Alternate HuRef
- Range
- 114244065..114334229
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the cited
reason(s). Suppressed RefSeqs do not appear in BLAST databases, related sequence links,
or BLAST links (BLink), but may still be retrieved by clicking on their
accession.version below.
-
NM_024891.2: Suppressed sequence
- Description
- NM_024891.2: This RefSeq was permanently suppressed because it is primarily intronic sequence.