MAP3K9 mitogen-activated protein kinase kinase kinase 9 [Homo sapiens] - Gene

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Summary

Official Symbol: MAP3K9provided by HGNC
Official Full Name: mitogen-activated protein kinase kinase kinase 9provided by HGNC
Primary source: HGNC:6861
See related: Ensembl:ENSG00000006432; HPRD:15965; MIM:600136; Vega:OTTHUMG00000171249
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MLK1; MEKK9; PRKE1

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Genomic context

Location :: 14q24.3-q31

Sequence :: Chromosome: 14; NC_000014.8 (71194852..71275888, complement)

See MAP3K9 in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

It was found that 24% of melanoma cell lines have mutations in the protein-coding regions of either MAP3K5 or MAP3K9.
Title: Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
estrogen receptor-alpha transcriptional activity is repressed by the Rho/megakaryoblastic leukemia 1 signaling pathway
Title: Repression of the estrogen receptor-alpha transcriptional activity by the Rho/megakaryoblastic leukemia 1 signaling pathway.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
P80192	P80192	MAP3K9		HPRD	PubMed
P80192	SH3 multiple domains 2	SH3RF1		HPRD	PubMed

Function	Evidence Code	Pubs
ATP binding	NAS Non-traceable Author Statement more info
JUN kinase kinase kinase activity	ISS Inferred from Sequence or Structural Similarity more info
MAP kinase kinase activity	NAS Non-traceable Author Statement more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
MAPK cascade	NAS Non-traceable Author Statement more info	PubMed
activation of JNKK activity	ISS Inferred from Sequence or Structural Similarity more info
activation of JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
activation of MAPK activity	NAS Non-traceable Author Statement more info	PubMed
apoptotic process	IEA Inferred from Electronic Annotation more info
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	NAS Non-traceable Author Statement more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
response to stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info

General protein information

Preferred Names: mitogen-activated protein kinase kinase kinase 9

Names: mitogen-activated protein kinase kinase kinase 9; mixed lineage kinase 1 (tyr and ser/thr specificity)

NP_149132.2

EC 2.7.11.25

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033141.2 → NP_149132.2 mitogen-activated protein kinase kinase kinase 9

Status: VALIDATED

Source sequence(s)

AY327900, BC033197, BX648924

Consensus CDS

CCDS32112.1

UniProtKB/Swiss-Prot

P80192

UniProtKB/TrEMBL

Q8NEB1

Related

ENSP00000451263, OTTHUMP00000245577, ENST00000555993, OTTHUMT00000412551

Conserved Domains (3) summary

cd00174
Location:56 – 113
Blast Score: 168

SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

cd00192
Location:148 – 404
Blast Score: 627

PTKc; Catalytic domain of Protein Tyrosine Kinases

smart00219
Location:144 – 403
Blast Score: 809

TyrKc; Tyrosine kinase, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

71194852..71275888, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

51363347..51444280, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC004816.1 (18202..99238)	None
genomic	CH471061.1	EAW81045.1
		EAW81046.1
mRNA	AF251442.1	AAG44591.1
mRNA	AK091645.1	BAG52397.1
mRNA	AK123430.1	None
mRNA	AK294571.1	BAG57765.1
mRNA	AK299727.1	BAG61625.1
mRNA	AK302849.1	BAG64036.1
mRNA	AY327900.1	AAQ23054.1
mRNA	BC033197.1	AAH33197.1
mRNA	BC040716.2	None
mRNA	BC043010.2	None
mRNA	BC111407.1	AAI11408.1
mRNA	BC133706.1	AAI33707.1
mRNA	BX648924.1	None