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    Pp1alpha-96A Protein phosphatase 1alpha at 96A [ Drosophila melanogaster ]

    Gene ID: 42922, updated on 10-May-2012
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    Summary

    Official Symbol
    Pp1alpha-96Aprovided by Flybase
    Official Full Name
    Protein phosphatase 1alpha at 96Aprovided by Flybase
    Primary source
    FLYBASE:FBgn0003134
    Locus tag
    Dmel_CG6593
    Gene type
    protein coding
    RNA name
    protein phosphatase 1alpha at 96A
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    96A; CG6593; Dmel\CG6593; DmPp1-96A; PP1; PP1 96A; PP1 alpha96a; Pp1-96A; pp1alpha96A; PP1alpha96A; PP1alpha[[1]]; PP1c; PP1c 96A
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    Genomic context

    Location :
    96A5-96A5
    Sequence :
    Chromosome: 3R; NT_033777.2 (20343979..20347065)
    See Pp1alpha-96A in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene nicotinic Acetylcholine Receptor beta 96A Neighboring gene CG13617 gene product from transcript CG13617-RA Neighboring gene CG13622 gene product from transcript CG13622-RB Neighboring gene CG13618 gene product from transcript CG13618-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Horn T, et al. Nat Methods, 2011 Apr. PMID 21378980.
    3. Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. Finan D, et al. Proc Natl Acad Sci U S A, 2011 Apr 5. PMID 21368190.
    4. Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. Kong EC, et al. Alcohol Clin Exp Res, 2010 Feb. PMID 19951294.
    5. Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Cronin SJ, et al. Science, 2009 Jul 17. PMID 19520911.

    See all (40) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Overexpression of the PP1 alpha isozymes does not rescue semilethal PP1 beta 9C mutants, whereas overexpression of either PP1 alpha 96A or PP1 beta 9C does rescue a lethal PP1 alpha 87B mutant combination.
      Title: Essential, overlapping and redundant roles of the Drosophila protein phosphatase 1 alpha and 1 beta genes.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:67848 BioGRID:60738 A16    BioGRID  PubMed Two-hybrid 
    BioGRID:67848 BioGRID:59647 Axud1    BioGRID  PubMed Two-hybrid 
    BioGRID:67848 BioGRID:60007 CG13996    BioGRID  PubMed Two-hybrid 
    BioGRID:67848 BioGRID:61597 CG1553    BioGRID  PubMed Two-hybrid 
    BioGRID:67848 BioGRID:58377 CG32685    BioGRID  PubMed Two-hybrid 
    BioGRID:67848 BioGRID:59065 CG8316    BioGRID  PubMed Two-hybrid 
    BioGRID:67848 BioGRID:58907 CG9170    BioGRID  PubMed Two-hybrid 
    BioGRID:67848 BioGRID:64921 CG9238    BioGRID  PubMed Two-hybrid 
    BioGRID:67848 BioGRID:64543 I-2    BioGRID  PubMed Affinity Capture-MS; Phenotypic Suppression 
    BioGRID:67848 BioGRID:69245 NiPp1    BioGRID  PubMed Phenotypic Suppression; Two-hybrid 
    BioGRID:67848 BioGRID:68171 TfIIA-L    BioGRID  PubMed Two-hybrid 
    BioGRID:67848 BioGRID:63592 mri    BioGRID  PubMed Two-hybrid 
    BioGRID:67848 BioGRID:67127 sds22    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:67848 BioGRID:63496 uri    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the Pp1alpha-96A gene: The Pp1alpha-96A gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.

    Pathways from BioSystems

    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein serine/threonine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein dephosphorylation NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    protein phosphatase type 1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG6593 gene product from transcript CG6593-RA
    Names
    CG6593-PA
    Pp1alpha-96A-PA
    protein phosphatase 1
    protein phosphatase 1alpha at 96A
    NP_524484.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      20343979..20347065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079760.2 → NP_524484.1  protein phosphatase 1alpha at 96A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48461
      Related
      FBpp0084026, FBtr0084642
      Conserved Domains (2) summary
      cd07414
      Location:13 – 298
      Blast Score: 1712
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
      smart00156
      Location:28 – 297
      Blast Score: 1081
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014297.2 AAF56306.1
    mRNA BT016110.1 AAV36995.1
    mRNA X56438.1 CAA39820.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48461.1 GenPept
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    Additional Links

    Gene LinkOut

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