These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_007109.2 RefSeqGene
- Range
- 5001..62497
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_000249.3 → NP_000240.1 DNA mismatch repair protein Mlh1 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
- Source sequence(s)
-
BC006850, CN414955
- Consensus CDS
-
CCDS2663.1
- UniProtKB/Swiss-Prot
-
P40692
- UniProtKB/TrEMBL
-
Q5GJ64
- Related
- ENSP00000231790, OTTHUMP00000161361, ENST00000231790, OTTHUMT00000253337
- Conserved Domains (3) summary
-
- cd00075
Location:31 – 122
Blast Score: 107
- HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
- cd03483
Location:211 – 335
Blast Score: 542
- MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
- TIGR00585
Location:6 – 315
Blast Score: 1082
- mutl; DNA mismatch repair protein MutL
-
NM_001167617.1 → NP_001161089.1 DNA mismatch repair protein Mlh1 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) contains a distinct 5'-terminal exon and therefore lacks an in-frame portion of the 5' coding region compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
- Source sequence(s)
-
AK298583, BC006850, DA517219
- Consensus CDS
-
CCDS54562.1
- UniProtKB/TrEMBL
-
B4DQ11
- UniProtKB/TrEMBL
-
E9PCU2
- UniProtKB/Swiss-Prot
-
P40692
- Related
- ENSP00000402564, OTTHUMP00000210162, ENST00000435176, OTTHUMT00000341986
- Conserved Domains (2) summary
-
- cd03483
Location:113 – 237
Blast Score: 542
- MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
- TIGR00585
Location:4 – 217
Blast Score: 655
- mutl; DNA mismatch repair protein MutL
-
NM_001167618.1 → NP_001161090.1 DNA mismatch repair protein Mlh1 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) contains a distinct 5'-terminal exon and uses an alternate splice site in a 5' exon and therefore lacks an in-frame portion of the 5' coding region compared to variant 1. The resulting isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3, 4, 6, and 7 all encode the same isoform (3).
- Source sequence(s)
-
AK295359, BC006850, DA517219
- Consensus CDS
-
CCDS54563.1
- UniProtKB/TrEMBL
-
B4DI13
- UniProtKB/Swiss-Prot
-
P40692
- Related
- ENSP00000398272, OTTHUMP00000210161, ENST00000455445, OTTHUMT00000341985
- Conserved Domains (2) summary
-
- COG0323
Location:2 – 334
Blast Score: 246
- MutL; DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]
- cd03483
Location:1 – 94
Blast Score: 443
- MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
-
NM_001167619.1 → NP_001161091.1 DNA mismatch repair protein Mlh1 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) contains a distinct 5'-terminal exon and lacks a 5' exon and therefore lacks an in-frame portion of the 5' coding region compared to variant 1. The resulting isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3, 4, 6, and 7 all encode the same isoform (3).
- Source sequence(s)
-
AK316074, BC006850, DA517219
- Consensus CDS
-
CCDS54563.1
- UniProtKB/TrEMBL
-
B4DI13
- UniProtKB/Swiss-Prot
-
P40692
- Related
- ENSP00000443665, ENST00000539477
- Conserved Domains (2) summary
-
- COG0323
Location:2 – 334
Blast Score: 246
- MutL; DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]
- cd03483
Location:1 – 94
Blast Score: 443
- MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
-
NM_001258271.1 → NP_001245200.1 DNA mismatch repair protein Mlh1 isoform 4
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
- Source sequence(s)
-
AB209848, BC006850, CN414955
- Conserved Domains (3) summary
-
- cd00075
Location:31 – 122
Blast Score: 107
- HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
- cd03483
Location:211 – 335
Blast Score: 542
- MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
- TIGR00585
Location:6 – 315
Blast Score: 1081
- mutl; DNA mismatch repair protein MutL
-
NM_001258273.1 → NP_001245202.1 DNA mismatch repair protein Mlh1 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1. Variants 3, 4, 6, and 7 all encode the same isoform (3).
- Source sequence(s)
-
AK316264, BC006850, CN414955
-
NM_001258274.1 → NP_001245203.1 DNA mismatch repair protein Mlh1 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) differs in the 5' UTR and contains an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1. Variants 3, 4, 6, and 7 all encode the same isoform (3).
- Source sequence(s)
-
AC011816, BC006850, BX648844
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000003.11 Reference GRCh37.p5 Primary Assembly
- Range
- 37034841..37092337
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000135.1 Alternate HuRef
- Range
- 36975521..37033106
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)