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CG6178 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42867, updated on 4-Apr-2024

Summary

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Official Symbol
CG6178provided by FlyBase
Primary source
FLYBASE:FBgn0039156
Locus tag
Dmel_CG6178
See related
AllianceGenome:FB:FBgn0039156
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6178; FACL
Summary
Enables long-chain fatty acid-CoA ligase activity. Involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. Predicted to be located in peroxisome. Is expressed in several structures, including dorsal ectoderm; embryonic Malpighian tubule; extended germ band embryo; presumptive embryonic/larval system; and yolk nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
95E5-95E6; 3-83 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24152347..24154896)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19978069..19980618)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene p38c MAP kinase Neighboring gene p38a MAP kinase Neighboring gene Myosin 95E Neighboring gene TBC1 domain family member 7 Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene Adenomatous polyposis coli 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Luciferase Activity of Insect Fatty Acyl-CoA Synthetases with Synthetic Luciferins. Mofford DM, et al. ACS Chem Biol, 2017 Dec 15. PMID 29073357, Free PMC Article
  2. Latent luciferase activity in the fruit fly revealed by a synthetic luciferin. Mofford DM, et al. Proc Natl Acad Sci U S A, 2014 Mar 25. PMID 24616520, Free PMC Article
  3. Functional conversion of fatty acyl-CoA synthetase to firefly luciferase by site-directed mutagenesis: a key substitution responsible for luminescence activity. Oba Y, et al. FEBS Lett, 2009 Jun 18. PMID 19450587
  4. Catalytic properties of domain-exchanged chimeric proteins between firefly luciferase and Drosophila fatty Acyl-CoA synthetase CG6178. Oba Y, et al. Biosci Biotechnol Biochem, 2006 Nov. PMID 17090919
  5. Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions. Inouye S. Cell Mol Life Sci, 2010 Feb. PMID 19859663

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phylogenetic analysis indicated that firefly luciferase and CG6178 genes belong to the group of plant 4-coumarate
    Title: Enzymatic and genetic characterization of firefly luciferase and Drosophila CG6178 as a fatty acyl-CoA synthetase.
  2. The enzymatic properties of CG6178 including substrate specificity, pH dependency and optimal temperature were close to those of firefly luciferase and rat fatty acyl-CoA synthetase.
    Title: Characterization of CG6178 gene product with high sequence similarity to firefly luciferase in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables CoA-ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables fatty acid ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables luciferin monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty-acyl-CoA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG6178-PA
fatty Acyl-CoA synthetase
fatty acyl-CoA synthase
NP_651221.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24152347..24154896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142964.3 → NP_651221.1  uncharacterized protein Dmel_CG6178 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651221.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VCC6
    Related
    FBpp0083935
    Conserved Domains (2) summary
    cd05911
    Location:43 → 529
    Firefly_Luc_like; Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL)
    PLN02246
    Location:26 → 537
    PLN02246; 4-coumarate--CoA ligase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VCC6 Q9VCC6

Gene LinkOut

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