Tsc1 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: Tsc1provided by Flybase
Primary source: FLYBASE:FBgn0026317
Locus tag: Dmel_CG6147
Gene type: protein coding
RNA name: Tsc1
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6147; Dmel\CG6147; dTSC; dTSC-1; dTsc1; dTSC1; rocky; TSC; tsc1; TSC1

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Genomic context

Location :: 95E1-95E1

Sequence :: Chromosome: 3R; NT_033777.2 (19956032..19960376)

See Tsc1 in Epigenomics, MapViewer

Chromosome 3R - NT_033777.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TSC1/2 and Myc coordinate the growth and division of Drosophila intestinal stem cells.
Title: Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells.
TSC1 regulates E2F1 expression during development and cooperates with RBF1 to control proliferation and survival.
Title: Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival.
TSC1/2 prevents precocious GSC differentiation by inhibiting TORC1 activity and subsequently differentiation-promoting programs
Title: TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation.
Tsc-mediated control of axon guidance and synapse assembly occurs via growth-independent signaling mechanisms, and suggest that Tor complex 2, a regulator of actin organization, is critical in these aspects of neuronal development
Title: Mechanisms of TSC-mediated control of synapse assembly and axon guidance.
shows that phosphorylation of the Tsc1/2 complex by Akt is not required for Akt to activate TORC1 and to promote tissue growth in Drosophila
Title: Akt phosphorylates both Tsc1 and Tsc2 in Drosophila, but neither phosphorylation is required for normal animal growth.
Results suggest that TSC1/2 and Rheb have different effects on the activity of TORC1 and -2, further supporting the complexity of TOR regulation.
Title: TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
Tsc1 and Tsc2 function in the insulin/phosphoinositide 3-kinase (PI3K)/Akt pathway. (REVIEW)
Title: The tuberous sclerosis complex (TSC) pathway and mechanism of size control.
Mutations in Tsc1 cause tuberous sclerosis.
Title: Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.
the Tsc1-Tsc2 complex antagonizes the TOR-mediated response to amino acid availability
Title: Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling.
negative regulators of cell division; control of transition from G0/G1 to S phase; cell size
Title: Tuberous sclerosis complex genes: from flies to human genetics.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:67795	BioGRID:65854	7B2	BioGRID	PubMed	Two-hybrid
BioGRID:67795	BioGRID:67008	Akt1	BioGRID	PubMed	Phenotypic Suppression
BioGRID:67795	BioGRID:58285	CG15365	BioGRID	PubMed	Two-hybrid
BioGRID:67795	BioGRID:68004	CG4673	BioGRID	PubMed	Two-hybrid
BioGRID:67795	BioGRID:60616	CG6287	BioGRID	PubMed	Two-hybrid
BioGRID:67795	BioGRID:62567	Cdk4	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:67795	BioGRID:64701	CycA	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:67795	BioGRID:58898	CycD	BioGRID	PubMed	Phenotypic Suppression
BioGRID:67795	BioGRID:60939	CycE	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:67795	BioGRID:67515	InR	BioGRID	PubMed	Phenotypic Suppression
BioGRID:67795	BioGRID:68762	Pten	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:67795	BioGRID:66301	Ras85D	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:67795	BioGRID:65943	Rm62	BioGRID	PubMed	Two-hybrid
BioGRID:67795	BioGRID:62064	RnrS	BioGRID	PubMed	Two-hybrid
BioGRID:67795	BioGRID:60443	RpL7	BioGRID	PubMed	Two-hybrid
BioGRID:67795	BioGRID:64114	S6k	BioGRID	PubMed	Phenotypic Suppression
BioGRID:67795	BioGRID:70789	Tor	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Suppression
BioGRID:67795	BioGRID:57835	dm	BioGRID	PubMed	Phenotypic Suppression
BioGRID:67795	BioGRID:61188	dnt	BioGRID	PubMed	Two-hybrid
BioGRID:67795	BioGRID:68664	eIF4G	BioGRID	PubMed	Two-hybrid
BioGRID:67795	BioGRID:65467	gig	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:67795	BioGRID:58172	p115	BioGRID	PubMed	Two-hybrid
BioGRID:67795	BioGRID:66998	srp	BioGRID	PubMed	Two-hybrid
BioGRID:67795	BioGRID:64880	ssp2	BioGRID	PubMed	Two-hybrid

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General gene information

Pathways from BioSystems

Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem (from REACTOME)
Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IRS-mediated signalling, organism-specific biosystem (from REACTOME)
IRS-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IRS-related events, organism-specific biosystem (from REACTOME)
IRS-related events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Inhibition of TSC complex formation by PKB, organism-specific biosystem (from REACTOME)
Inhibition of TSC complex formation by PKB, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
Insulin receptor signalling cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K Cascade, organism-specific biosystem (from REACTOME)
PI3K Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PKB-mediated events, organism-specific biosystem (from REACTOME)
PKB-mediated events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Rheb GTPase activity by AMPK, organism-specific biosystem (from REACTOME)
Regulation of Rheb GTPase activity by AMPK, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
Signaling by Insulin receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
mTOR signaling pathway, organism-specific biosystem (from KEGG)
mTOR signaling pathway, organism-specific biosystem
mTOR signaling pathway
mTOR signaling pathway, conserved biosystem (from KEGG)
mTOR signaling pathway, conserved biosystem
mTOR signaling pathway
mTOR signalling, organism-specific biosystem (from REACTOME)
mTOR signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
insulin receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
lipid metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of cell growth	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell growth	TAS Traceable Author Statement more info	PubMed
negative regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell size	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell size	NAS Non-traceable Author Statement more info	PubMed
negative regulation of cell size	TAS Traceable Author Statement more info	PubMed
negative regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of organ growth	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell cycle	TAS Traceable Author Statement more info	PubMed
regulation of cell growth	TAS Traceable Author Statement more info	PubMed
regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info
regulation of organ growth	NAS Non-traceable Author Statement more info	PubMed
regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info
regulation of timing of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
response to nutrient	IMP Inferred from Mutant Phenotype more info	PubMed
signal transduction	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed

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General protein information

Preferred Names: CG6147 gene product from transcript CG6147-RA

Names: CG6147-PA; TTuberous sclerosis complex 1; Tsc1; Tsc1-PA; hamartin; rocky; tuberous sclerosis 1; tuberous sclerosis complex 1

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.2

Range

19956032..19960376

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058067.2 → NP_477415.1 Tsc1 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9VCC9

Related

FBpp0083931, FBtr0084546

Conserved Domains (3) summary

COG1196
Location:672 – 942
Blast Score: 166

Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]

pfam04388
Location:2 – 715
Blast Score: 1782

Hamartin; Hamartin protein

cl09720
Location:802 – 914
Blast Score: 89

HrpB7; Bacterial type III secretion protein (HrpB7)