eIF4G2 eukaryotic translation initiation factor 4G2 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: eIF4G2provided by Flybase
Official Full Name: eukaryotic translation initiation factor 4G2provided by Flybase
Primary source: FLYBASE:FBgn0260634
Locus tag: Dmel_CG10192
Gene type: protein coding
RNA name: eukaryotic translation initiation factor 4G2
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10192; Dmel\CG10192; ms(3)nc32; nc32; ofs

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Genomic context

Location :: 95B9-95C1; 3-82.9 cM

Sequence :: Chromosome: 3R; NT_033777.2 (19635550..19644364, complement)

See eIF4G2 in Epigenomics, MapViewer

Chromosome 3R - NT_033777.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Translational control of meiotic cell cycle progression and spermatid differentiation in male germ cells by a novel eIF4G homolog, eIF4G2.
Title: Translational control of meiotic cell cycle progression and spermatid differentiation in male germ cells by a novel eIF4G homolog.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:67755	BioGRID:64886	26-29-p	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:65093	CG13067	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:62132	CG13157	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:62971	CG13427	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:67584	CG13857	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:65675	CG14563	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:72487	CG17018	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:63504	CG3548	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:63536	CG3589	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:65337	CG3961	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:78090	CG40160	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:63213	CG42565	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:65115	CG4998	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:65479	CG6933	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:64280	CG7548	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:59423	Cda5	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:63970	Chd64	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:65121	Cpr72Ea	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:63230	CycB	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:57559	Cyp4g1	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:62190	Nmda1	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:61725	Pgi	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:58594	Rab40	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:66477	RpS25	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:68066	Sld5	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:69548	cathD	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:65450	hale	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:62642	mbl	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:57575	mod(r)	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:65209	rogdi	BioGRID	PubMed	Two-hybrid
BioGRID:67755	BioGRID:69991	shi	BioGRID	PubMed	Two-hybrid

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General gene information

Pathways from BioSystems

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem (from REACTOME)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
Cap-dependent Translation Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Deadenylation of mRNA, organism-specific biosystem (from REACTOME)
Deadenylation of mRNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Deadenylation-dependent mRNA decay, organism-specific biosystem (from REACTOME)
Deadenylation-dependent mRNA decay, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
Eukaryotic Translation Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IRS-mediated signalling, organism-specific biosystem (from REACTOME)
IRS-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IRS-related events, organism-specific biosystem (from REACTOME)
IRS-related events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
Insulin receptor signalling cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K Cascade, organism-specific biosystem (from REACTOME)
PI3K Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PKB-mediated events, organism-specific biosystem (from REACTOME)
PKB-mediated events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ribosomal scanning and start codon recognition, organism-specific biosystem (from REACTOME)
Ribosomal scanning and start codon recognition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
S6K1 signalling, organism-specific biosystem (from REACTOME)
S6K1 signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
S6K1-mediated signalling, organism-specific biosystem (from REACTOME)
S6K1-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
Signaling by Insulin receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translation, organism-specific biosystem (from REACTOME)
Translation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
mTOR signalling, organism-specific biosystem (from REACTOME)
mTOR signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
mTORC1-mediated signalling, organism-specific biosystem (from REACTOME)
mTORC1-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
RNA 7-methylguanosine cap binding	IDA Inferred from Direct Assay more info	PubMed
translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
G1/S transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
RNA metabolic process	IEA Inferred from Electronic Annotation more info
autophagic cell death	IEP Inferred from Expression Pattern more info	PubMed
male meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
meiotic G2/MI transition	IMP Inferred from Mutant Phenotype more info	PubMed
salivary gland cell autophagic cell death	IEP Inferred from Expression Pattern more info	PubMed
spermatid differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
translational initiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
eukaryotic translation initiation factor 4F complex	ISS Inferred from Sequence or Structural Similarity more info

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General protein information

Preferred Names: CG10192 gene product from transcript CG10192-RA

Names: CG10192-PA; eIF-4G-like protein; eIF4G2-PA; eukaryotic translation initiation factor 4G2; male sterile (3) nc32; off-schedule

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.2

Range

19635550..19644364, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_142931.3 → NP_651188.1 eukaryotic translation initiation factor 4G2 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9VCH1

Related

FBpp0088566, FBtr0089623

Conserved Domains (2) summary

cl02653
Location:1697 – 1812
Blast Score: 276

MA3; MA3 domain

cl02652
Location:1274 – 1514
Blast Score: 431

MIF4G; MIF4G domain