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Rpn9 Regulatory particle non-ATPase 9 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42802, updated on 4-Apr-2024

Summary

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Official Symbol
Rpn9provided by FlyBase
Official Full Name
Regulatory particle non-ATPase 9provided by FlyBase
Primary source
FLYBASE:FBgn0028691
Locus tag
Dmel_CG10230
See related
AllianceGenome:FB:FBgn0028691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0718/06; 718/06; CG10230; CT28749; Dmel\CG10230; l(3)S071806; l(3)S071806b; p39A; PSMD13; Rpn4; rpn9; Rpn94; S11
Summary
Predicted to enable structural molecule activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in several structures, including adult heart; anterior endoderm anlage; embryonic/larval midgut primordium; germ layer; and gonad. Orthologous to human PSMD13 (proteasome 26S subunit, non-ATPase 13). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
95B1-95B1; 3-80 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23731375..23733462, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19557097..19559184, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribonuclease MRP RNA Neighboring gene HMG Coenzyme A reductase Neighboring gene antisense RNA:CR46091 Neighboring gene Ran binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of Dsk2/dUbqln results in severe developmental defects and lethality in Drosophila melanogaster that can be rescued by overexpression of the p54/Rpn10/S5a proteasomal subunit. Lipinszki Z, et al. FEBS J, 2011 Dec. PMID 21973017
  2. Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process. Tonoki A, et al. Mol Cell Biol, 2009 Feb. PMID 19075009, Free PMC Article
  3. Ubiquitylation of Drosophila p54/Rpn10/S5a regulates its interaction with the UBA-UBL polyubiquitin receptors. Lipinszki Z, et al. Biochemistry, 2012 Mar 27. PMID 22364263
  4. The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together. Pathare GR, et al. Proc Natl Acad Sci U S A, 2012 Jan 3. PMID 22187461, Free PMC Article
  5. Molecular characterization of the Rpt1/p48B ATPase subunit of the Drosophila melanogaster 26S proteasome. Szabó A, et al. Mol Genet Genomics, 2007 Jul. PMID 17429695

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, lid subcomplex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
regulatory particle non-ATPase 9
Names
CG10230-PA
CG10230-PB
Rpn9-PA
Rpn9-PB
nobody
p39A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23731375..23733462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170088.2 → NP_732899.1  regulatory particle non-ATPase 9, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732899.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMP8
    Related
    FBpp0083860
    Conserved Domains (1) summary
    smart00753
    Location:269 → 361
    PAM; PCI/PINT associated module

  2. NM_142920.3 → NP_651177.1  regulatory particle non-ATPase 9, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651177.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMP8
    Related
    FBpp0083861
    Conserved Domains (1) summary
    smart00753
    Location:269 → 361
    PAM; PCI/PINT associated module
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KMP8 Q7KMP8

Gene LinkOut

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