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    NOS1 nitric oxide synthase 1 (neuronal) [ Gallus gallus (chicken) ]

    Gene ID: 427721, updated on 15-Jun-2013
    Symbol
    NOS1provided by CGNC
    Full Name
    nitric oxide synthase 1 (neuronal)provided by CGNC
    Primary source
    CGNC:6202
    See related
    Ensembl:ENSGALG00000008177
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Testudines + Archosauria group; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus
    Location :
    chromosome: 15
    Sequence :
    Chromosome: 15; NC_006102.3 (11287023..11314321)
    See NOS1 in MapViewer

    Chromosome 15 - NC_006102.3Genomic Context describing neighboring genes Neighboring gene WD repeat and SOCS box containing 2 Neighboring gene replication factor C (activator 1) 5, 36.5kDa Neighboring gene F-box protein 21 Neighboring gene tescalcin

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion. Socodato R, et al. J Biol Chem, 2012 Nov 9. PMID 22992730.
    2. Embryonic motor neuron dendrite growth is stunted by inhibition of nitric oxide-dependent activation of soluble guanylyl cyclase and protein kinase G. Xiong G, et al. Eur J Neurosci, 2007 Apr. PMID 17439487.
    3. Calcium-binding proteins, neuronal nitric oxide synthase, and GABA help to distinguish different pallial areas in the developing and adult chicken. I. Hippocampal formation and hyperpallium. Suárez J, et al. J Comp Neurol, 2006 Aug 10. PMID 16786551.
    4. Distribution of GABA, calbindin and nitric oxide synthase in the developing chick entopallium. Suárez J, et al. Brain Res Bull, 2005 Sep 15. PMID 16144628.

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion
      Title: Calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion.
    2. At E10, the number of nNOS cells were observed.From E12 on, there was a decrease in the expression of nNOS.
      Title: Distribution of GABA, calbindin and nitric oxide synthase in the developing chick entopallium.
    3. Neuronal nitric oxide synthase showed a specific spatiotemporal expression pattern and was expressed in a region (area)-specific but dynamic manner during development of the hippocampus and hyperpallium.
      Title: Calcium-binding proteins, neuronal nitric oxide synthase, and GABA help to distinguish different pallial areas in the developing and adult chicken. I. Hippocampal formation and hyperpallium.
    4. Results suggest that normal motor neuron dendrite elaboration depends on the generation of nitric oxide by neuronal nitric oxide synthase in ventral horn interneurons, which then activates soluble guanylyl cyclase and protein kinase G in motor neurons.
      Title: Embryonic motor neuron dendrite growth is stunted by inhibition of nitric oxide-dependent activation of soluble guanylyl cyclase and protein kinase G.
    Submit: New GeneRIF Correction
    • Arginine and proline metabolism, organism-specific biosystem (from KEGG)
      Arginine and proline metabolism, organism-specific biosystem
      Arginine and proline metabolism
    • Arginine and proline metabolism, conserved biosystem (from KEGG)
      Arginine and proline metabolism, conserved biosystem
      Arginine and proline metabolism
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...

    Genotypes

    Homology

    Preferred Names
    nitric oxide synthase, brain
    Names
    nitric oxide synthase 1 (neuronal)

    RefSeqs of Annotated Genomes: Build 3.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Gallus_gallus-4.0 Primary Assembly

    Genomic

    1. NC_006102.3

      Range
      11287023..11314321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_425296.2 → XP_425296.2  

      Related
      ENSGALP00000013280, ENSGALT00000013295
      Conserved Domains (5) summary
      cd00992
      Location:15 – 98
      Blast Score: 174
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd00795
      Location:304 – 715
      Blast Score: 2137
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      COG0369
      Location:751 – 1399
      Blast Score: 772
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      cd06202
      Location:1000 – 1403
      Blast Score: 1844
      Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
      pfam00258
      Location:761 – 934
      Blast Score: 257
      Flavodoxin_1; Flavodoxin
    Nucleotide Protein
    Heading Accession and Version
    genomic AADN03007166.1 (79671..106969) None

    Gene LinkOut

      Supplemental Content

      Table of contents

      Related information

      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • Taxonomy
        Link to related taxonomy entry

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