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orb oo18 RNA-binding protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42752, updated on 11-Apr-2024

Summary

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Official Symbol
orbprovided by FlyBase
Official Full Name
oo18 RNA-binding proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0004882
Locus tag
Dmel_CG10868
See related
AllianceGenome:FB:FBgn0004882
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
151666_s_at; CG10868; Dmel\CG10868; fs(3)00107; oo18; Oo18; Orb; ORB; Orb1; ORB1
Summary
Predicted to enable mRNA 3'-UTR binding activity; ribosome binding activity; and translation regulator activity, nucleic acid binding. Involved in mRNA polyadenylation; oogenesis; and regulation of oskar mRNA translation. Located in cell cortex. Part of ribonucleoprotein complex. Is expressed in several structures, including deutocerebrum; gonad; intrinsic neurons; primordial germ cell; and wing disc. Orthologous to human CPEB1 (cytoplasmic polyadenylation element binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
94E9-94E9; 3-78 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23260610..23280856, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19086332..19106578, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Elongin A Neighboring gene will decrease acetylation Neighboring gene Peroxin 11c Neighboring gene Cell division cycle 16 Neighboring gene uncharacterized protein Neighboring gene wampa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mapping parameter spaces of biological switches. Diegmiller R, et al. PLoS Comput Biol, 2021 Feb. PMID 33556054, Free PMC Article
  2. The cytoplasmic polyadenylation element binding protein (CPEB), Orb, is important for dendrite development and neuron fate specification in Drosophila melanogaster. Olesnicky EC, et al. Gene, 2020 May 15. PMID 32057929
  3. Age-specific mortality and reproduction respond to adult dietary restriction in Drosophila melanogaster. Good TP, et al. J Insect Physiol, 2001 Dec. PMID 12770153
  4. A cost of reproduction in Drosophila melanogaster: stress susceptibility. Salmon AB, et al. Evolution, 2001 Aug. PMID 11580019
  5. A Brief History of Drosophila (Female) Meiosis. Fellmeth JE, et al. Genes (Basel), 2022 Apr 27. PMID 35627159, Free PMC Article

See all (372) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. To be or not to be: orb, the fusome and oocyte specification in Drosophila.
    Title: To be or not to be: orb, the fusome and oocyte specification in Drosophila.
  2. Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles.
    Title: Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles.
  3. maintenance of oocyte identity requires continuous orb activity.
    Title: The Drosophila CPEB Protein Orb Specifies Oocyte Fate by a 3'UTR-Dependent Autoregulatory Loop.
  4. orb is required during mid-oogenesis for the translation of the posterior/germline determinant oskar mRNA and the dorsal-ventral determinant gurken mRNA. Here, we report that orb also functions upstream of these axes determinants in the polarization of the microtubule network.
    Title: The CPEB translational regulator, Orb, functions together with Par proteins to polarize the Drosophila oocyte.
  5. The juxtaposition of RNA motifs enables cooperative regulation by CPEB1 and Msi1.
    Title: Dueling RNA-binding proteins promote translational activation.
  6. Localized cytoplasmic polyadenylation of grk mRNA by Wisp and Orb is necessary to achieve appropriate Grk protein accumulation in the D/A corner of the oocyte during mid to late oogenesis.
    Title: Wispy and Orb cooperate in the cytoplasmic polyadenylation of localized gurken mRNA.
  7. autophagy is an essential pathway regulated by Orb during early oogenesis
    Title: Translational Control of Autophagy by Orb in the Drosophila Germline.
  8. Rasputin functions as a positive regulator of orb in Drosophila oogenesis.
    Title: Rasputin functions as a positive regulator of orb in Drosophila oogenesis.
  9. ORB protein in Drosophila mushroom body output neurons is necessary for long-term memory formation
    Title: Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation.
  10. Cup blocks the precocious activation of the orb autoregulatory loop
    Title: Cup blocks the precocious activation of the orb autoregulatory loop.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables mRNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables mRNA regulatory element binding translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation factor activity, RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dorsal/ventral axis specification, ovarian follicular epithelium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dorsal/ventral axis specification, ovarian follicular epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oocyte anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pole plasm oskar mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of oskar mRNA translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of messenger ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
oo18 RNA-binding protein
Names
CG10868-PA
CG10868-PB
CG10868-PC
CG10868-PD
CG10868-PE
CG10868-PF
CG10868-PG
ORB
Oo18 RNA-binding protein
oo18 RNA binding
oo18 RNA binding protein
orb-PA
orb-PB
orb-PC
orb-PD
orb-PE
orb-PF
orb-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23260610..23280856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275941.1 → NP_001262870.1  oo18 RNA-binding protein, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262870.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D4G7D4, Q24433, Q9VCN7
    Conserved Domains (4) summary
    cd12723
    Location:574 → 674
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:685 → 770
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:762 → 817
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:540 → 570
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

  2. NM_079736.3 → NP_524460.2  oo18 RNA-binding protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524460.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D4G7D4, Q24433, Q9VCN7
    Related
    FBpp0083776
    Conserved Domains (4) summary
    cd12723
    Location:574 → 674
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:685 → 770
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:762 → 817
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:540 → 570
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

  3. NM_170062.2 → NP_732848.1  oo18 RNA-binding protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732848.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAC0, Q8IMZ3
    Related
    FBpp0083777
    Conserved Domains (4) summary
    cd12723
    Location:572 → 672
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:683 → 768
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:760 → 815
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:538 → 568
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

  4. NM_170064.2 → NP_732850.1  oo18 RNA-binding protein, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732850.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHE0, Q8IMZ2
    Related
    FBpp0083778
    Conserved Domains (4) summary
    cd12723
    Location:218 → 318
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:329 → 414
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:406 → 461
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:184 → 214
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

  5. NM_170063.2 → NP_732849.2  oo18 RNA-binding protein, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732849.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAC0, Q8IMZ3
    Conserved Domains (4) summary
    cd12723
    Location:572 → 672
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:683 → 768
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:760 → 815
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:538 → 568
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

  6. NM_170065.2 → NP_732851.2  oo18 RNA-binding protein, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732851.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHE0, Q8IMZ2
    Conserved Domains (4) summary
    cd12723
    Location:218 → 318
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:329 → 414
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:406 → 461
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:184 → 214
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

  7. NM_001170228.1 → NP_001163699.1  oo18 RNA-binding protein, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163699.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHC3, Q8IHE0
    Conserved Domains (4) summary
    cd12723
    Location:276 → 376
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:387 → 472
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:464 → 519
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:242 → 272
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24433 Q24433
Q8IHC3 Q8IHC3
Q8IHE0 Q8IHE0
Q8IMZ2 Q8IMZ2
Q8IMZ3 Q8IMZ3
Q9VCN7 Q9VCN7

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