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Efa6 Exchange factor for Arf 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42665, updated on 4-Apr-2024

Summary

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Official Symbol
Efa6provided by FlyBase
Official Full Name
Exchange factor for Arf 6provided by FlyBase
Primary source
FLYBASE:FBgn0051158
Locus tag
Dmel_CG31158
See related
AllianceGenome:FB:FBgn0051158
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18185; CG31158; CG6941; dEfa6; Dmel\CG31158; dPsd; efa6; EFA6
Summary
Enables microtubule binding activity. Involved in several processes, including axoneme assembly; compound eye morphogenesis; and negative regulation of microtubule polymerization. Located in axon; cell body; and cell cortex. Colocalizes with adherens junction. Is expressed in adult head. Used to study alcohol use disorder. Orthologous to several human genes including PSD (pleckstrin and Sec7 domain containing). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
94B5-94B6; 3-75 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22587755..22608842)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18413477..18434564)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene buttonless Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosome recycling factor 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans. Gonzalez DA, et al. Mol Psychiatry, 2018 Mar. PMID 28607459, Free PMC Article
  2. Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors. Casanova JE. Traffic, 2007 Nov. PMID 17850229
  3. Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex. Qu Y, et al. Elife, 2019 Nov 13. PMID 31718774, Free PMC Article
  4. Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers. Cox R, et al. Mol Biol Cell, 2004 Apr. PMID 14742722, Free PMC Article
  5. Cell-type-specific, multicolor labeling of endogenous proteins with split fluorescent protein tags in Drosophila. Kamiyama R, et al. Proc Natl Acad Sci U S A, 2021 Jun 8. PMID 34074768, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ARF protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in response to alcohol IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
colocalizes_with adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
exchange factor for Arf 6
Names
CG31158-PC
CG31158-PD
CG31158-PG
CG31158-PH
CG31158-PI
Efa6 pleckstrin and Sec7 domain containing
Efa6-PC
Efa6-PD
Efa6-PG
Efa6-PH
Efa6-PI
exchange factor for Arf 6 ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22587755..22608842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170027.4 → NP_732769.3  exchange factor for Arf 6, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732769.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2QD55
    Conserved Domains (4) summary
    cd00171
    Location:910 → 1079
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd00992
    Location:7 → 85
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13295
    Location:1116 → 1238
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
    pfam00169
    Location:1120 → 1231
    PH; PH domain

  2. NM_001170220.2 → NP_001163691.2  exchange factor for Arf 6, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163691.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8JR81, A8JR82, A8WHG2, C0PUX2, E1JIT7, E2QD55, E2QD56, Q8MRV5
    Conserved Domains (4) summary
    PHA03269
    Location:225 → 344
    PHA03269; envelope glycoprotein C; Provisional
    cd00171
    Location:1124 → 1293
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd00992
    Location:7 → 85
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13295
    Location:1330 → 1452
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

  3. NM_176541.3 → NP_788718.3  exchange factor for Arf 6, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788718.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2QD56
    Conserved Domains (4) summary
    cd00171
    Location:1044 → 1213
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd00992
    Location:7 → 85
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13295
    Location:1250 → 1372
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
    pfam00169
    Location:1254 → 1365
    PH; PH domain

  4. NM_001104404.2 → NP_001097874.1  exchange factor for Arf 6, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097874.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JR81
    Conserved Domains (4) summary
    cd00171
    Location:1044 → 1213
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd00992
    Location:7 → 85
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13295
    Location:1250 → 1372
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
    pfam00169
    Location:1254 → 1365
    PH; PH domain

  5. NM_001104403.2 → NP_001097873.1  exchange factor for Arf 6, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097873.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JR82
    Conserved Domains (4) summary
    cd00171
    Location:910 → 1079
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd00992
    Location:7 → 85
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13295
    Location:1116 → 1238
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
    pfam00169
    Location:1120 → 1231
    PH; PH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JIT7.2 E1JIT7

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