MGST1 microsomal glutathione S-transferase 1 [Homo sapiens] - Gene

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Summary

Official Symbol: MGST1provided by HGNC
Official Full Name: microsomal glutathione S-transferase 1provided by HGNC
Primary source: HGNC:7061
See related: Ensembl:ENSG00000008394; HPRD:00705; MIM:138330; Vega:OTTHUMG00000168816
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MGST; GST12; MGST-I; MGC14525
Summary: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

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Genomic context

Location :: 12p12.3-p12.1

Sequence :: Chromosome: 12; NC_000012.11 (16500076..16517344)

See MGST1 in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MGST1 protects cells (and mitochondria) by both conjugation and glutathione peroxidase functions. A new protective mechanism against cisplatin is also indicated
Title: Multiple roles of microsomal glutathione transferase 1 in cellular protection: a mechanistic study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis.
Genes encoding KU70, MGST1 and BIK show age-related mRNA expression levels in hematopoietic stem cells.
Title: Age-related transcription levels of KU70, MGST1 and BIK in CD34+ hematopoietic stem and progenitor cells.
The results indicate that Sp1 is the protein mediating the basal transcription of MGST1
Title: Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3.
Polymorphisms in microsomal glutathione s transferase is associated with laryngeal cancer
Title: Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk.
As an addition to the high-density SNP (single-nucleotide polymorphism) maps of 12 glutathione S-transferase and related genes reported earlier, a SNP map of the microsomal glutathione S-transferase 1 (MGST1) gene is provided.
Title: Catalog of 46 single-nucleotide polymorphisms (SNPs) in the microsomal glutathione S-transferase 1 (MGST1) gene.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P10620	Q16873	LTC4S	HPRD	PubMed
P10620	P10620	MGST1	HPRD	PubMed
BioGRID:110413	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
glutathione binding	IEA Inferred from Electronic Annotation more info
glutathione transferase activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info
protein homodimerization activity	IEA Inferred from Electronic Annotation more info
transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Leydig cell differentiation	IEA Inferred from Electronic Annotation more info
glutathione metabolic process	IEA Inferred from Electronic Annotation more info
protein homotrimerization	ISS Inferred from Sequence or Structural Similarity more info
response to drug	IEA Inferred from Electronic Annotation more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
response to organic nitrogen	IEA Inferred from Electronic Annotation more info
small molecule metabolic process	TAS Traceable Author Statement more info
xenobiotic metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
apical part of cell	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum membrane	TAS Traceable Author Statement more info
integral to membrane	ISS Inferred from Sequence or Structural Similarity more info
membrane	IEA Inferred from Electronic Annotation more info
microsome	ISS Inferred from Sequence or Structural Similarity more info
mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
mitochondrion	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info
peroxisomal membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: microsomal glutathione S-transferase 1

Names: microsomal glutathione S-transferase 1; microsomal GST-1; microsomal GST-I; glutathione S-transferase 12

NP_064696.1

EC 2.5.1.18

NP_665707.1

EC 2.5.1.18

NP_665734.1

EC 2.5.1.18

NP_665735.1

EC 2.5.1.18

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001260511.1 → NP_001247440.1 microsomal glutathione S-transferase 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 all encode the same isoform (a).

Source sequence(s)

AW166965, BC005923, BG569388, BG617746

Conserved Domains (1) summary

cl09190
Location:19 – 149
Blast Score: 221

MAPEG; MAPEG family
NM_001260512.1 → NP_001247441.1 microsomal glutathione S-transferase 1 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and contains an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AC007528, AW166965, BC005923, BE568125, BG617746
NM_020300.4 → NP_064696.1 microsomal glutathione S-transferase 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (2, also called 1b) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 all encode the same isoform (a).

Source sequence(s)

AW166965, BC005923, BG617746

Consensus CDS

CCDS8677.1

UniProtKB/Swiss-Prot

P10620

Related

ENSP00000379513, OTTHUMP00000239525, ENST00000396210, OTTHUMT00000401181

Conserved Domains (1) summary

cl09190
Location:19 – 149
Blast Score: 221

MAPEG; MAPEG family
NM_145764.2 → NP_665707.1 microsomal glutathione S-transferase 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (4, also called 1d) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 all encode the same isoform (a).

Source sequence(s)

AW166965, BC005923, J03746

Consensus CDS

CCDS8677.1

UniProtKB/Swiss-Prot

P10620

Related

ENSP00000379510, OTTHUMP00000239530, ENST00000396207, OTTHUMT00000401189

Conserved Domains (1) summary

cl09190
Location:19 – 149
Blast Score: 221

MAPEG; MAPEG family
NM_145791.2 → NP_665734.1 microsomal glutathione S-transferase 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (3, also called 1c) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 all encode the same isoform (a).

Source sequence(s)

AA314967, AV655242, AW166965, BC005923

Consensus CDS

CCDS8677.1

UniProtKB/Swiss-Prot

P10620

Related

ENSP00000379512, ENST00000396209

Conserved Domains (1) summary

cl09190
Location:19 – 149
Blast Score: 221

MAPEG; MAPEG family
NM_145792.2 → NP_665735.1 microsomal glutathione S-transferase 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1, also called 1a) encodes isoform a. Variants 1, 2, 3, 4, and 5 all encode the same isoform (a).

Source sequence(s)

AW166965, BC005923, R86750

Consensus CDS

CCDS8677.1

UniProtKB/Swiss-Prot

P10620

Related

ENSP00000010404, ENST00000010404

Conserved Domains (1) summary

cl09190
Location:19 – 149
Blast Score: 221

MAPEG; MAPEG family

RNA

NR_048545.1 RNA Sequence

Description

Transcript Variant: This variant (7) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting transcript has no open reading frames capable of encoding a protein >100 aa, so it is thought that this transcript is non-protein coding.

Source sequence(s)

AW166965, BC005923, BG778603
NR_048546.1 RNA Sequence

Description

Transcript Variant: This variant (8) differs in the 5' UTR and contains an alternate 3'-most exon compared to variant 1, that causes a frameshift. The resulting transcript has no open reading frames capable of encoding a protein >100 aa, so it is thought that this transcript is non-protein coding.

Source sequence(s)

AC007528, BC056863, BG617746
NR_048547.1 RNA Sequence

Description

Transcript Variant: This variant (9) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting transcript has no open reading frames capable of encoding a protein >100 aa, so it is thought that this transcript is non-protein coding.

Source sequence(s)

AA314967, AW166965, BC005923

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

16500076..16517344

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

16268374..16285639

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC007528.5 (53686..70954)	None
genomic	AY368173.1	AAQ55111.1
genomic	CH471094.1	EAW96362.1
		EAW96363.1
		EAW96364.1
		EAW96365.1
		EAW96366.1
		EAW96367.1
		EAW96368.1
		EAW96369.1
genomic	U46498.1	AAC50711.1
genomic	U46499.1	None
genomic	U71213.1	AAB17184.1
mRNA	AA314967.1	None
mRNA	AK291148.1	BAF83837.1
mRNA	AK309707.1	None
mRNA	BC005923.1	AAH05923.1
mRNA	BC056863.1	None
mRNA	BT006982.1	AAP35628.1
mRNA	CR407629.1	CAG28557.1
mRNA	H49331.1	None
mRNA	J03746.1	AAA35934.1
mRNA	R86750.1	None