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    MGMT O-6-methylguanine-DNA methyltransferase [ Homo sapiens ]

    Gene ID: 4255, updated on 20-May-2012

    Summary

    Official Symbol
    MGMTprovided by HGNC
    Official Full Name
    O-6-methylguanine-DNA methyltransferaseprovided by HGNC
    Primary source
    HGNC:7059
    Locus tag
    RP11-109A6.1
    See related
    Ensembl:ENSG00000170430; HPRD:01135; MIM:156569; Vega:OTTHUMG00000019261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

    Genomic context

    Location :
    10q26
    Sequence :
    Chromosome: 10; NC_000010.10 (131265454..131565783)
    See MGMT in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, E Neighboring gene antigen identified by monoclonal antibody Ki-67 Neighboring gene uncharacterized LOC100506006 Neighboring gene microRNA 4297 Neighboring gene early B-cell factor 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P16455 Q92793 CREBBP    HPRD  PubMed  
    P16455 P68400 CSNK2A1    HPRD  PubMed  
    P16455 Q09472 EP300    HPRD  PubMed  
    P16455 P17612 PRKACA    HPRD  PubMed  
    P16455 P17252 PRKCA    HPRD  PubMed  
    P16455 P22314 UBA1    HPRD  PubMed  
    X61657.1 NP_778224.1 HIST4H4    BIND  PubMed HIST4H4 (H4) interacts with the MGMT promoter. 
    BioGRID:110411 BioGRID:106575 ACTB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:123548 ANP32E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:106798 ANXA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:106799 ANXA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:107142 BRCA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110411 BioGRID:107332 CCNB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110411 BioGRID:107420 CDK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110411 BioGRID:114128 CDK10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:119715 CDK12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110411 BioGRID:112668 CDKL5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:107460 CDKN1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110411 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110411 BioGRID:107841 CSNK2A1    BioGRID  PubMed Biochemical Activity 
    BioGRID:110411 BioGRID:107842 CSNK2A2    BioGRID  PubMed Biochemical Activity 
    BioGRID:110411 BioGRID:121353 DDX24    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:108021 DDX5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:108237 EEF1A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:108238 EEF1A2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:108253 EEF1B2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:114216 EIF3H    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110411 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110411 BioGRID:108399 FBL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:117623 FBXO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:125992 FBXO27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:130376 H2BFM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:113932 HIST1H2AM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:113955 HIST1H4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:113895 HIST3H3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:109422 HNRNPA2B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:109424 HNRNPC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110411 BioGRID:109558 HSP90AB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:122310 IL25    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:110035 KPNB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:110339 MCM2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110411 BioGRID:110340 MCM3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:110573 MSH2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:110731 MYO7A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:110771 NCL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:111040 ORC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110411 BioGRID:111079 PABPC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110411 BioGRID:111264 PHB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:111332 PKM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:111420 POLD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110411 BioGRID:111553 PRKACA    BioGRID  PubMed Biochemical Activity 
    BioGRID:110411 BioGRID:111564 PRKCA    BioGRID  PubMed Biochemical Activity 
    BioGRID:110411 BioGRID:111569 PRKCH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:114576 PRPF4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:111687 PSMD9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:111693 PSME2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:111741 PTPN4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:114492 RNF8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:112095 RPLP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:112124 RPS15A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:112316 SET    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:106788 SLC25A4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:106790 SLC25A6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:113871 SMC1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:112604 SRP9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:112627 SSRP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:113003 TOP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:113125 TTPA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:124259 TUBA1C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:115656 TUBB4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:113162 UBB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:110411 BioGRID:116078 USP19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:113272 VIM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:113321 WNT9B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110411 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • DNA Damage Reversal, organism-specific biosystem (from REACTOME)
      DNA Damage Reversal, organism-specific biosystemDNA damage can be directly reversed by dealkylation.
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. These cellular mechanisms that must cope with the plethora of DNA base pair ad...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-methyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methylated-DNA-[protein]-cysteine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    methyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA dealkylation involved in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    DNA ligation TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA methylation TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA repair TAS
    Traceable Author Statement
    more info
     
    cellular response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    methylation TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell death IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to folic acid IEA
    Inferred from Electronic Annotation
    more info
     
    response to toxin IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    methylated-DNA--protein-cysteine methyltransferase
    Names
    methylated-DNA--protein-cysteine methyltransferase
    methylguanine-DNA methyltransferase
    O-6-methylguanine-DNA-alkyltransferase
    O6-methylguanine-DNA methyltransferase
    6-O-methylguanine-DNA methyltransferase
    NP_002403.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002412.3NP_002403.2  methylated-DNA--protein-cysteine methyltransferase

      Status: VALIDATED

      Source sequence(s)
      AK293593, DC387686
      Consensus CDS
      CCDS7660.2
      UniProtKB/TrEMBL
      B4DEE8
      Related
      ENSP00000302111, OTTHUMP00000020741, ENST00000306010, OTTHUMT00000051009
      Conserved Domains (2) summary
      cd06445
      Location:125204
      Blast Score: 316
      ATase; The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases ...
      pfam02870
      Location:37121
      Blast Score: 162
      Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      131265454..131565783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      124842441..125144551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL157832.14 CAH70060.1
    genomic AL353725.14 None
    genomic AL355531.16 CAH72190.1
    genomic CH471066.2 EAW49166.1
      EAW49167.1
    genomic S52068.1 AAD13867.2
    mRNA AK293593.1 BAG57059.1
    mRNA BC000824.1 AAH00824.1
    mRNA BI520029.1 None
    mRNA BT006714.1 AAP35360.1
    mRNA DC387686.1 None
    mRNA M29971.1 AAA59596.1
    mRNA M31767.1 AAA52317.1
    mRNA M60761.1 AAA59594.1
    mRNA X54228.1 CAA38137.1
    other-genetic DQ890723.2 ABM81649.1
    other-genetic DQ893901.2 ABM84827.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16455.1 GenPept UniProtKB/Swiss-Prot:P16455
    Q6LDD1 GenPept UniProtKB/TrEMBL:Q6LDD1

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