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    C15 [ Drosophila melanogaster ]

    Gene ID: 42544, updated on 8-Jan-2012
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    Summary

    Official Symbol
    C15provided by Flybase
    Primary source
    FLYBASE:FBgn0004863
    Locus tag
    Dmel_CG7937
    Gene type
    protein coding
    RNA name
    C15
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    311; 93Bal; c15; CG7937; cll; Cll; Dmel\CG7937; Ect5; Hox11-311
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    Genomic context

    Location :
    93E3-93E3
    Sequence :
    Chromosome: 3R; NT_033777.2 (17325977..17338054)
    See C15 in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene ladybird early Neighboring gene CG7922 gene product from transcript CG7922-RA Neighboring gene CG7956 gene product from transcript CG7956-RA Neighboring gene CG15499 gene product from transcript CG15499-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless. Miyazono K, et al. EMBO J, 2010 May 5. PMID 20389279.
    2. Stalled Hox promoters as chromosomal boundaries. Chopra VS, et al. Genes Dev, 2009 Jul 1. PMID 19515973.
    3. A systematic analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development. Liu YH, et al. Dev Cell, 2009 Feb. PMID 19217429.
    4. Spatial specificity of mesodermal even-skipped expression relies on multiple repressor sites. Liu J, et al. Dev Biol, 2008 Jan 15. PMID 18067885.
    5. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.

    See all (31) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. In the Al-Cll-DNA complex structure, the residues in the extended regions are used not only for the intermolecular contacts between the two homeodomain proteins but also for the sequence-recognition mechanism of DNA by direct interactions.
      Title: Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.
    2. Body patterning of legs is a product of this gene.
      Title: Regulation of gene expression in the distal region of the Drosophila leg by the Hox11 homolog, C15.
    3. Data show that Aristaless and Clawless proteins form a complex capable of binding to specific DNA targets, which cannot be well recognized solely by Aristaless or Clawless.
      Title: A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox11/tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg.
    4. Mutational analysis shows that the number of Smad- and Zen-binding sites is essential for the C15 transcriptional response, and the spatial limits of C15 expression are established through a repression mechanism in the dorsolateral cells of the embryo.
      Title: Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:67510 BioGRID:64208 CG10075    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:72500 CG11985    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:60307 CG13090    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:68334 CG14506    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:62860 CG15109    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:68440 CG15529    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:72594 CG15919    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:63269 CG3085    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:58346 CG3099    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:72631 CG32354    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:57666 CG32810    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:64477 CG3689    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:67577 CG5380    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:67634 CG6972    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:67466 CG7056    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:62545 CG7997    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:66210 CG8116    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:65414 CG8786    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:60341 CG9573    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:65565 CSN3    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:64601 Cpr67Fa2    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:64442 Doc2    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:61336 E2f2    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:64320 Ect4    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:58239 Es2    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:70621 Exp6    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:67143 Hmx    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:60119 Hrb27C    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:67368 Hs6st    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:64238 Neos    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:65943 Rm62    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:67060 Scp2    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:58532 Tango10    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:61146 Tango6    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:57879 Tip60    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:57861 VhaAC39    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:63159 ari-2    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:61242 bsh    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:68720 fan    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:63957 fd64A    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:70018 mts    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:65288 mus304    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:65884 noi    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:62424 row    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:61542 so    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:70682 term    BioGRID  PubMed Two-hybrid 
    BioGRID:67510 BioGRID:68506 tll    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the C15 gene: The C15 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, zebrafish, and mosquito.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    antennal morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    elongation of arista core IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    leg disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mesodermal cell fate specification NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of Notch signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG7937 gene product from transcript CG7937-RA
    Names
    C15
    C15-PA
    CG7937-PA
    clawless
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      17325977..17338054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057525.2 → NP_476873.2  C15 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KS72
      Related
      FBpp0083510, FBtr0084111
      Conserved Domains (1) summary
      cd00086
      Location:218 – 272
      Blast Score: 175
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014297.2 AAF55898.2
    mRNA BT025203.2 ABF17894.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q7KS72.1 GenPept
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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