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CTAGE5 CTAGE family member 5 [ Homo sapiens (human) ]

Gene ID: 4253, updated on 26-May-2016
Official Symbol
CTAGE5provided by HGNC
Official Full Name
CTAGE family member 5provided by HGNC
Primary source
HGNC:HGNC:7057
See related
Ensembl:ENSG00000150527 HPRD:03680; MIM:602132; Vega:OTTHUMG00000140258
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEA6; MGEA; MGEA6; MGEA11
Summary
The protein encoded by this gene is a tumor-associated antigen found in cutaneous T-cell lymphoma and several other cancers. Autoantibodies against the encoded protein have been found in some cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Orthologs
Location:
14q13.3
Exon count:
31
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (39265272..39351193)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (39734476..39820397)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene YTH domain family member 2 pseudogene 1 Neighboring gene melanoma inhibitory activity 2 Neighboring gene uncharacterized LOC100288846 Neighboring gene coilin pseudogene 1 Neighboring gene F-box protein 33

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
    Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
  • Cargo concentration in the ER, organism-specific biosystem (from REACTOME)
    Cargo concentration in the ER, organism-specific biosystemComputational analysis suggests that ~25% of the proteome may be exported from the ER in human cells (Kanapin et al, 2003). These cargo need to be recognized and concentrated into COPII vesicles, wh...
  • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
    ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
    Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme activator activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cTAGE family member 5
Names
CTAGE family, member 5
cutaneous T-cell lymphoma-associated antigen 5
meningioma expressed antigen 6 (coiled-coil proline-rich)
meningioma-expressed antigen 6/11
protein cTAGE-5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030349.1 RefSeqGene

    Range
    5001..90922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001247988.1NP_001234917.1  cTAGE family member 5 isoform 5

    See identical proteins and their annotated locations for NP_001234917.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence, lacks an alternate in-frame exon, and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. The resulting isoform (5) is shorter at the N-terminus and lacks two internal segments compared to isoform 6.
    Source sequence(s)
    AF338233, AI521895, AK091252, AL132639, AL833415
    UniProtKB/Swiss-Prot
    O15320
    Conserved Domains (2) summary
    pfam06409
    Location:369442
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:308415
    Tropomyosin_1; Tropomyosin like
  2. NM_001247989.1NP_001234918.1  cTAGE family member 5 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents the longest transcript and encodes the longest isoform (6).
    Source sequence(s)
    AI521895, AL132639, BC064355, CV809109
    Consensus CDS
    CCDS58316.1
    UniProtKB/Swiss-Prot
    O15320
    Related
    ENSP00000379462, ENST00000396158
    Conserved Domains (2) summary
    pfam06409
    Location:403476
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:342449
    Tropomyosin_1; Tropomyosin like
  3. NM_001247990.1NP_001234919.1  cTAGE family member 5 isoform 7

    See identical proteins and their annotated locations for NP_001234919.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 6. The resulting isoform (7) is shorter at the N-terminus compared to isoform 6.
    Source sequence(s)
    AI521895, AL132639, BC051363, CV809109
    Consensus CDS
    CCDS58317.1
    UniProtKB/Swiss-Prot
    O15320
    Related
    ENSP00000452562, OTTHUMP00000244236, ENST00000556148, OTTHUMT00000410035
    Conserved Domains (2) summary
    pfam06409
    Location:323396
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:262369
    Tropomyosin_1; Tropomyosin like
  4. NM_005930.3NP_005921.2  cTAGE family member 5 isoform 1

    See identical proteins and their annotated locations for NP_005921.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. The resulting isoform (1) lacks an internal segment compared to isoform 6.
    Source sequence(s)
    AB209528, AL132639, CV809109, U94780
    Consensus CDS
    CCDS9674.1
    UniProtKB/Swiss-Prot
    O15320
    UniProtKB/TrEMBL
    Q59FD2
    Related
    ENSP00000280083, OTTHUMP00000178901, ENST00000280083, OTTHUMT00000276771
    Conserved Domains (2) summary
    pfam06409
    Location:398471
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:337444
    Tropomyosin_1; Tropomyosin like
  5. NM_203354.2NP_976229.1  cTAGE family member 5 isoform 2

    See identical proteins and their annotated locations for NP_976229.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. The resulting isoform (2) has a shorter and distinct N-terminus and lacks an internal segment compared to isoform 6.
    Source sequence(s)
    AB209528, AL132639, DA072098
    Consensus CDS
    CCDS9673.1
    UniProtKB/Swiss-Prot
    O15320
    UniProtKB/TrEMBL
    Q59FD2
    Related
    ENSP00000343897, OTTHUMP00000178900, ENST00000341749, OTTHUMT00000276770
    Conserved Domains (2) summary
    pfam06409
    Location:386459
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:325432
    Tropomyosin_1; Tropomyosin like
  6. NM_203355.2NP_976230.1  cTAGE family member 5 isoform 3

    See identical proteins and their annotated locations for NP_976230.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. The resulting isoform (3) lacks two internal segments compared to isoform 6.
    Source sequence(s)
    AL132639, BC029513, CV809109
    Consensus CDS
    CCDS9675.1
    UniProtKB/TrEMBL
    Q4G155
    Related
    ENSP00000343912, OTTHUMP00000178902, ENST00000348007, OTTHUMT00000276772
    Conserved Domains (2) summary
    pfam06409
    Location:398471
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:337444
    Tropomyosin_1; Tropomyosin like
  7. NM_203356.2NP_976231.1  cTAGE family member 5 isoform 4

    See identical proteins and their annotated locations for NP_976231.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence, initiates translation at a downstream start codon, and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. The resulting isoform (4) is shorter at the N-terminus and lacks an internal segment compared to isoform 6. Unlike the other variants, this variant may exhibit testis-specific expression.
    Source sequence(s)
    AF338233, AL132639
    Consensus CDS
    CCDS9676.1
    UniProtKB/Swiss-Prot
    O15320
    Related
    ENSP00000379468, OTTHUMP00000178903, ENST00000396165, OTTHUMT00000276773
    Conserved Domains (2) summary
    pfam06409
    Location:369442
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:308415
    Tropomyosin_1; Tropomyosin like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    39265272..39351193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536778.1XP_011535080.1  

    Conserved Domains (2) summary
    pfam06409
    Location:395468
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:334441
    Tropomyosin_1; Tropomyosin like
  2. XM_011536785.1XP_011535087.1  

    See identical proteins and their annotated locations for XP_011535087.1

    UniProtKB/Swiss-Prot
    O15320
    Related
    ENSP00000450869, OTTHUMP00000244235, ENST00000557038, OTTHUMT00000410034
    Conserved Domains (2) summary
    pfam06409
    Location:318391
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:257364
    Tropomyosin_1; Tropomyosin like
  3. XM_011536783.1XP_011535085.1  

    See identical proteins and their annotated locations for XP_011535085.1

    Conserved Domains (2) summary
    pfam06409
    Location:327400
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:266373
    Tropomyosin_1; Tropomyosin like
  4. XM_011536779.1XP_011535081.1  

    See identical proteins and their annotated locations for XP_011535081.1

    Conserved Domains (2) summary
    pfam06409
    Location:378451
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:317424
    Tropomyosin_1; Tropomyosin like
  5. XM_011536776.1XP_011535078.1  

    Conserved Domains (2) summary
    pfam06409
    Location:401474
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:340447
    Tropomyosin_1; Tropomyosin like
  6. XM_005267648.3XP_005267705.1  

    Conserved Domains (2) summary
    pfam06409
    Location:392465
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:331438
    Tropomyosin_1; Tropomyosin like
  7. XM_011536780.1XP_011535082.1  

    See identical proteins and their annotated locations for XP_011535082.1

    Conserved Domains (2) summary
    pfam06409
    Location:378451
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:317424
    Tropomyosin_1; Tropomyosin like
  8. XM_011536781.1XP_011535083.1  

    See identical proteins and their annotated locations for XP_011535083.1

    Conserved Domains (2) summary
    pfam06409
    Location:378451
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:317424
    Tropomyosin_1; Tropomyosin like
  9. XM_006720148.1XP_006720211.1  

    See identical proteins and their annotated locations for XP_006720211.1

    UniProtKB/Swiss-Prot
    O15320
    Related
    ENSP00000450449, OTTHUMP00000244237, ENST00000553352, OTTHUMT00000410036
    Conserved Domains (2) summary
    pfam06409
    Location:369442
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:308415
    Tropomyosin_1; Tropomyosin like
  10. XM_011536775.1XP_011535077.1  

    Conserved Domains (2) summary
    pfam06409
    Location:407480
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:346453
    Tropomyosin_1; Tropomyosin like
  11. XM_011536784.1XP_011535086.1  

    See identical proteins and their annotated locations for XP_011535086.1

    UniProtKB/Swiss-Prot
    O15320
    Conserved Domains (2) summary
    pfam06409
    Location:318391
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:257364
    Tropomyosin_1; Tropomyosin like
  12. XM_011536782.1XP_011535084.1  

    See identical proteins and their annotated locations for XP_011535084.1

    Conserved Domains (2) summary
    pfam06409
    Location:327400
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam12718
    Location:266373
    Tropomyosin_1; Tropomyosin like

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    39733093..39818981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_203357.1: Suppressed sequence

    Description
    NM_203357.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.