SCGB2A2 secretoglobin, family 2A, member 2 [Homo sapiens] - Gene

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Summary

Official Symbol: SCGB2A2provided by HGNC
Official Full Name: secretoglobin, family 2A, member 2provided by HGNC
Primary source: HGNC:7050
See related: Ensembl:ENSG00000110484; HPRD:05712; MIM:605562; Vega:OTTHUMG00000167509
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MGB1; UGB2; MGC71974

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Genomic context

Location :: 11q13

Sequence :: Chromosome: 11; NC_000011.9 (62037630..62040628)

See SCGB2A2 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that HLA-A24-restricted, mammaglobin-A (Mam-A) derived, CD8(+) cytotoxic T lymphocyte (CTL) epitopes that can potentially be employed for Mam-A-based breast cancer vaccine therapy to breast cancer patients with HLA-A24 phenotype.
Title: Identification of HLA-A24-restricted CD8(+) cytotoxic T-cell epitopes derived from mammaglobin-A, a human breast cancer-associated antigen.
A decrease in MGB1+mRNA levels (baseline-week 8) seemed to be associated with clinical response (P = 0.05).
Title: Cytokeratin-19 and mammaglobin gene expression in circulating tumor cells from metastatic breast cancer patients enrolled in North Central Cancer Treatment Group trials, N0234/336/436/437.
MGA detection by the modified nested RT-PCR is a specific marker for circulating tumor cells in patients with breast carcinoma and a negative prognostic factor for the disease
Title: Detection of mammaglogin A in blood from breast cancer patients, before and after treatment, using a one-tube nested PCR protocol. Association with the absence of tumor estrogen receptors.
High serum mammaglobin is associated with breast cancer.
Title: Cloning expression, monoclonal antibody preparation and serologic study of mammaglobin in breast cancer.
The current knowledge regarding the use of reverse-transcriptase PCR for detecting human mammaglobin mRNA as a biomarker for circulating tumor cells in breast cancer patients, is reviewed.
Title: Human mammaglobin: a superior marker for reverse-transcriptase PCR in detecting circulating tumor cells in breast cancer patients.
The expression of hMAG was found to be increased with breast cancer grade.
Title: Expression of human mammaglobin and clinicopathologic correlations in breast cancer: the findings in Malaysia.
Most basal-like breast carcinomas and unclassified triple-negative carcinomas are negative for mammaglobin and gross cystic disease fluid protein 15.
Title: Relationship between molecular subtype of invasive breast carcinoma and expression of gross cystic disease fluid protein 15 and mammaglobin.
Results showed the prognostic relevance of bone marrow disseminated tumor cells assessed by a multimarker mRNA panel consisting of TWIST1, cytokeratin 19 (gene name: KRT19), and mammaglobin A (gene name: SCGB2A2) mRNA in operable breast cancer patients.
Title: Disseminated tumor cells in bone marrow assessed by TWIST1, cytokeratin 19, and mammaglobin A mRNA predict clinical outcome in operable breast cancer patients.
Detection of Mammaglobin as part of a 3-marker RT-PCR for early diagnosis of breast cancer.
Title: Detection of cytokeratin 19, human mammaglobin, and carcinoembryonic antigen-positive circulating tumor cells by three-marker reverse transcription-PCR assay and its relation to clinical outcome in early breast cancer.
Data show that plasma mammaglobin mRNA alone or in combination with CA15.3 (CD227) may be used as a valuable noninvasive approach for the diagnosis and the detection of metastasis in breast cancer at the time of diagnosis.
Title: Plasma mammaglobin messenger RNA in breast cancer patients as an addition to serum tumor.

Submit: New GeneRIF Correction See all (33)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat upregulates the expression of many proteins, including Mammaglobin, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
Q13296	O95969	SCGB1D2		HPRD	PubMed

Function	Evidence Code	Pubs
binding	IEA Inferred from Electronic Annotation more info
molecular_function	ND No biological Data available more info
steroid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info
extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: mammaglobin-A

Names: mammaglobin-A; mammaglobin 1; mammaglobin A; mammaglobin-1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002411.2 → NP_002402.1 mammaglobin-A precursor

Status: PROVISIONAL

Source sequence(s)

U33147

Consensus CDS

CCDS8018.1

UniProtKB/Swiss-Prot

Q13296

Related

ENSP00000227918, OTTHUMP00000236065, ENST00000227918, OTTHUMT00000394860

Conserved Domains (1) summary

cd00633
Location:22 – 90
Blast Score: 151

Secretoglobin; Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with encoding genes sharing substantial sequence similarity. Their family subunits may be grouped into five subfamilies, A-E. Uteroglobin (subfamily A), which is identical ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p5 Primary Assembly

Range

62037630..62040628

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

58366037..58369049

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF015224.1	AAC39608.1
genomic	AP003306.2 (77740..80738)	None
genomic	CH471076.1	EAW74010.1
mRNA	AY217100.1	AAO60111.1
mRNA	BC067220.1	AAH67220.1
mRNA	BC128252.1	AAI28253.1
mRNA	BC128402.1	AAI28403.1
mRNA	U33147.1	AAC50375.1