Rlip Ral interacting protein [Drosophila melanogaster] - Gene

Help top of page

Summary

Official Symbol: Rlipprovided by Flybase
Official Full Name: Ral interacting proteinprovided by Flybase
Primary source: FLYBASE:FBgn0026056
Locus tag: Dmel_CG11622
Gene type: protein coding
RNA name: Ral interacting protein
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11622; D-RLIP; Dmel\CG11622; dRalBP; dRlip; dRLIP; RhoGAP-93B3; RLIP

Help top of page

Genomic context

Location :: 93B4-93B4

Sequence :: Chromosome: 3R; NT_033777.2 (16843423..16846475)

See Rlip in Epigenomics, MapViewer

Chromosome 3R - NT_033777.2 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RLIP/RalBP1 is used as a platform by the mitotic cdk1 to facilitate the phosphorylation of Epsin, which makes Epsin incompetent for endocytosis during mitosis, when endocytosis is switched off.
Title: RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.

Submit: New GeneRIF Correction

Help top of page

Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
NP_650933.2		AP-50	BIND	PubMed	D-RLIP interacts with Dmu-2.
NP_650933.2	NP_726882.1	Rala	BIND	PubMed	dRal interacts with dRalBP.
BioGRID:67455	BioGRID:67495	AP-2sigma	BioGRID	PubMed	Affinity Capture-MS
BioGRID:67455	BioGRID:67597	AP-50	BioGRID	PubMed	Affinity Capture-MS
BioGRID:67455	BioGRID:62436	Arf51F	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:59282	Bap	BioGRID	PubMed	Affinity Capture-MS
BioGRID:67455	BioGRID:59096	CG12985	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:64046	CG13711	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:64044	CG13712	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:66051	CG14610	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:59349	CG15452	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:62243	CG17050	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:77449	CG32086	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:66866	CG3610	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:63518	CG3683	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:64729	CG6793	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:65639	CG7172	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:58966	CG9784	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:65188	Lmpt	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:58274	Moe	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:61145	Nak	BioGRID	PubMed	Affinity Capture-MS
BioGRID:67455	BioGRID:57853	Rala	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:60604	Reps	BioGRID	PubMed	Affinity Capture-MS
BioGRID:67455	BioGRID:68230	RpL4	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:68486	Rpt6R	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:64841	SNCF	BioGRID	PubMed	Two-hybrid
BioGRID:67455	BioGRID:59467	alpha-Adaptin	BioGRID	PubMed	Affinity Capture-MS
BioGRID:67455	BioGRID:68436	sima	BioGRID	PubMed	Two-hybrid

Help top of page

General gene information

Homology

Homologs of the Rlip gene: The Rlip gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, and C.elegans.

Pathways from BioSystems

Rho GTPase cycle, organism-specific biosystem (from REACTOME)
Rho GTPase cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
Signaling by Rho GTPases, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
Ral GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
Ral GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
intracellular	IEA Inferred from Electronic Annotation more info

Help top of page

General protein information

Preferred Names: CG11622 gene product from transcript CG11622-RA

Names: CG11622-PA; Ral interacting protein; Rlip-PA

Help top of page

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.2

Range

16843423..16846475

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_142676.3 → NP_650933.2 Ral interacting protein [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VDG2

Related

FBpp0083406, FBtr0084002

Conserved Domains (2) summary

cd04381
Location:187 – 368
Blast Score: 663

RhoGap_RalBP1; RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 ...

smart00324
Location:205 – 372
Blast Score: 343

RhoGAP; GTPase-activator protein for Rho-like GTPases