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MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [ Homo sapiens (human) ]

Gene ID: 4247, updated on 11-Sep-2014
Official Symbol
MGAT2provided by HGNC
Official Full Name
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:7045
See related
Ensembl:ENSG00000168282; HPRD:04013; MIM:602616; Vega:OTTHUMG00000140271
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GNT2; CDG2A; CDGS2; GNT-II; GLCNACTII
Summary
The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
See MGAT2 in Epigenomics, MapViewer
Location:
14q21
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 14 NC_000014.9 (49620771..49623481)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (50087460..50090199)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ras homolog family member Q pseudogene 1 Neighboring gene leucine rich repeat protein 1 Neighboring gene ribosomal protein L36a pseudogene 42 Neighboring gene ribosomal protein L36a-like Neighboring gene dynein, axonemal, assembly factor 2 Neighboring gene polymerase (DNA directed), epsilon 2, accessory subunit Neighboring gene serine/threonine kinase 16 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 N-linked oligosaccharides are processed by manosidase I and II in the Golgi complex PubMed
env Specific alterations of the N-linked carbohydrates on HIV-1 gp120 and gp41 by glucosidases and mannosidase inhibitors can enhance mannose-binding lectin (MBL)-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL PubMed
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed
Envelope transmembrane glycoprotein gp41 env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
oligosaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
oligosaccharide metabolic process TAS
Traceable Author Statement
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein N-linked glycosylation TAS
Traceable Author Statement
more info
PubMed 
protein N-linked glycosylation via asparagine TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
Golgi stack IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Names
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
glcNAc-T II
mannoside acetylglucosaminyltransferase 2
Beta-1,2-N-acetylglucosaminyltransferase II
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
UDP-N-acetylglucosamine:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II
NP_002399.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008920.1 

    Range
    5001..7711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002408.3NP_002399.1  alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    See proteins identical to NP_002399.1

    Status: REVIEWED

    Source sequence(s)
    AK056167, BC006390, BI764270, BQ023756
    Consensus CDS
    CCDS9690.1
    UniProtKB/Swiss-Prot
    Q10469
    Related
    ENSP00000307423, OTTHUMP00000178926, ENST00000305386, OTTHUMT00000276807
    Conserved Domains (1) summary
    pfam05060
    Location:86440
    Blast Score: 1544
    MGAT2; N-acetylglucosaminyltransferase II (MGAT2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000014.9 

    Range
    49620771..49623481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000146.1 

    Range
    30204620..30207330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 

    Range
    50026493..50029203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001015883.1: Suppressed sequence

    Description
    NM_001015883.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.