SCGB2A1 secretoglobin, family 2A, member 1 [Homo sapiens] - Gene

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Summary

Official Symbol: SCGB2A1provided by HGNC
Official Full Name: secretoglobin, family 2A, member 1provided by HGNC
Primary source: HGNC:7051
See related: Ensembl:ENSG00000124939; HPRD:05096; MIM:604398; Vega:OTTHUMG00000167506
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LPHC; MGB2; UGB3; MGC71973

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Genomic context

Location :: 11q13

Sequence :: Chromosome: 11; NC_000011.9 (61976140..61981411)

See SCGB2A1 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that plasma mammaglobin mRNA alone or in combination with CA15.3 (CD227) may be used as a valuable noninvasive approach for the diagnosis and the detection of metastasis in breast cancer at the time of diagnosis.
Title: Plasma mammaglobin messenger RNA in breast cancer patients as an addition to serum tumor.
MGB-2 expression characterizes less aggressive forms of EOC and is correlated with a favorable outcome
Title: Mammaglobin B is an independent prognostic marker in epithelial ovarian cancer and its expression is associated with reduced risk of disease recurrence.
MGB-2 is highly expressed in endometrioid endometrial cancer [EEC], particularly in well- and moderately differentiated tumors, and may represent a novel molecular marker for EEC
Title: Mammaglobin B expression in human endometrial cancer.
Expression levels of mammaglobins A and B in nasal polyps are not different between patients with and without AR
Title: Expression of mammaglobins A and B in nasal polyps is similar in patients with and without allergic rhinitis.
Results indicate that mammaglobin, as measured by the ELISA, holds significant promise for breast cancer screening with the realistic potential to impact management of this disease.
Title: Identification of mammaglobin as a novel serum marker for breast cancer.
MGB2 markers may be useful for identifying micrometastases in sentinel lymph nodes of breast cancer patients.
Title: RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes.
The mammaglobin/lipophilin B complex is a promising diagnostic marker for breast cancer.
Title: Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer.
SCGB 2A1 represents a new class of androgen target genes that are purely under indirect AR control mediated by DNA-bound Sp factors.
Title: Secretoglobin 2A1 is under selective androgen control mediated by a peculiar binding site for Sp family transcription factors.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat upregulates the expression of many proteins, including Mammaglobin, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
O75556	O95968	SCGB1D1		HPRD	PubMed
BioGRID:110402	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
androgen binding	NAS Non-traceable Author Statement more info
binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info
extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: mammaglobin-B

Names: mammaglobin-B; lacryglobin; lipophilin C; lipophilin-C; mammaglobin 2; mammaglobin B; mammaglobin-2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002407.2 → NP_002398.1 mammaglobin-B precursor

Status: VALIDATED

Source sequence(s)

AF071219, AJ224173, BC062218

Consensus CDS

CCDS8016.1

UniProtKB/Swiss-Prot

O75556

Related

ENSP00000244930, OTTHUMP00000236063, ENST00000244930, OTTHUMT00000394857

Conserved Domains (1) summary

cd00633
Location:22 – 90
Blast Score: 159

Secretoglobin; Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with encoding genes sharing substantial sequence similarity. Their family subunits may be grouped into five subfamilies, A-E. Uteroglobin (subfamily A), which is identical ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p5 Primary Assembly

Range

61976140..61981411

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

58304514..58309811

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP003306.2 (16250..21518)	None
genomic	CH471076.1	EAW74008.1
genomic	GN341832.1	CAY39335.1
mRNA	AF071219.1	AAC79996.1
mRNA	AJ224173.1	CAA11865.1
mRNA	BC062218.1	AAH62218.1