GeneRIFs: Gene References Into Functions What's a GeneRIF?

1. Data show that the differential recruitment of the co-repressors Gro and CtBP by H in a context-dependent manner ensures fine tuning of Notch signaling activity during eye development.
   Title: Fine tuning of Notch signaling by differential co-repressor recruitment during eye development of Drosophila.
2. we identify a site in Hairless that is crucial for binding Su(H) protein
   Title: Structural and functional analysis of the repressor complex in the Notch signaling pathway of Drosophila melanogaster.
3. Hairless (H) is a Runt-interacting molecule that functions during segmentation. H is important for maintenance of engrailed (en) repression.
   Title: Hairless is a cofactor for Runt-dependent transcriptional regulation.
4. The results indicate that H induces apoptosis by downregulation of EGFR signalling activity.
   Title: Hairless induces cell death by downregulation of EGFR signalling activity.
5. Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. H directly binds two corepressor proteins, Groucho (Gro) and dCtBP.
   Title: Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless.
6. Two isoforms of the Notch antagonist Hairless are produced by differential translation initiation. The presence of either isoform throughout the cell cycle allows efficient inhibition of Notch-regulated cell proliferation.
   Title: Two isoforms of the Notch antagonist Hairless are produced by differential translation initiation.
7. Data show that Pros26.4 negatively regulates Hairless at the genetic and molecular level, providing a novel mechanism of positive regulation of Notch signalling.
   Title: A molecular link A molecular link between Hairless and Pros26.4, a member of the AAA-ATPase subunits of the proteasome 19S regulatory particle in Drosophila.
8. modifiers of the rough eye phenotype resulting from overexpression of the Notch antagonist hairless in Drosophila
   Title: Genetic screen for modifiers of the rough eye phenotype resulting from overexpression of the Notch antagonist hairless in Drosophila.
9. Hairless has a second mode of repression that antagonizes Notch intracellular domain and is independent of Gro or CtBP binding.
   Title: Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors.
10. Hairless is a central component of the regulation of the Notch signalling pathway in Drosophila, and is hence essential for cell differentiation and tissue development in the fly.
    Title: Hairless: the ignored antagonist of the Notch signalling pathway.