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    MET met proto-oncogene (hepatocyte growth factor receptor) [ Homo sapiens ]

    Gene ID: 4233, updated on 12-Feb-2012
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    Summary

    Official Symbol
    METprovided by HGNC
    Official Full Name
    met proto-oncogene (hepatocyte growth factor receptor)provided by HGNC
    Primary source
    HGNC:7029
    See related
    Ensembl:ENSG00000105976; HPRD:01280; MIM:164860; Vega:OTTHUMG00000023299
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HGFR; AUTS9; RCCP2; c-Met
    Summary
    The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    7q31
    Sequence :
    Chromosome: 7; NC_000007.13 (116312459..116438440)
    See MET in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene caveolin 2 Neighboring gene caveolin 1, caveolae protein, 22kDa Neighboring gene KIAA1468 pseudogene Neighboring gene capping protein (actin filament) muscle Z-line, alpha 2 Neighboring gene RNA, U2 small nuclear 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma. Snuderl M, et al. Cancer Cell, 2011 Dec 13. PMID 22137795.
    2. A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism. Fafalios A, et al. Nat Med, 2011 Nov 13. PMID 22081023.
    3. Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer. Graziano F, et al. J Clin Oncol, 2011 Dec 20. PMID 22042954.
    4. EGFR and KRAS mutations and altered c-Met gene copy numbers in primary non-small cell lung cancer and associated stage N2 lymph node-metastasis. Han CB, et al. Cancer Lett, 2012 Jan 1. PMID 21982684.
    5. Activating mutation in MET oncogene in familial colorectal cancer. Neklason DW, et al. BMC Cancer, 2011 Oct 4. PMID 21970370.

    See all (425) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. EGFR and c-Met may interact in a synergistic manner in the oncogenesis and development of non-small cell lung cancer. Expressions were higher in smokers than in nonsmokers.
      Title: [Detection of epidermal growth factor receptor and c-Met gene copies for prognostic evaluation of non-small cell lung cancer].
    2. multiple receptor tyrosine kinases are amplified in a subset of glioblastoma subclones, epidermal growth factor receptor, MET and platelet-derived growth factor receptor alpha
      Title: Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma.
    3. qPCR revealed approximately 10% of white patients with gastric cancer harboring MET copy number gain (CNG)of five or more copies.
      Title: Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer.
    4. Met stimulates hepatocyte glucose uptake through crosstalk with insulin receptor.
      Title: A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism.
    5. Data suggest that c-Met plays an oncogenic role in the development of NPC and as a potential novel therapeutic target for NPC.
      Title: Silencing of c-Met by RNA interference inhibits the survival, proliferation, and invasion of nasopharyngeal carcinoma cells.
    6. the molecular signatures of liver cancer in a c-MET-transgenic mouse model
      Title: Gene signatures derived from a c-MET-driven liver cancer mouse model predict survival of patients with hepatocellular carcinoma.
    7. this is the first report also implicating this MET genetic mutation as a germline inherited risk factor for familial colorectal cancer.
      Title: Activating mutation in MET oncogene in familial colorectal cancer.
    8. High level of MET and SOX2 expression were respectively demonstrated in ADCs and SCCs; MET activation was accompanied with exon 19 deletion in ADCs.
      Title: Expression of MET and SOX2 genes in non-small cell lung carcinoma with EGFR mutation.
    9. MET mutation is associated with treatment response in non-small cell lung cancer.
      Title: MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations.
    10. both primary and lymph-node metastases have relatively consistent EGFR mutations and EGFR mutations are not relevant to changes in c-Met gene copy number.
      Title: EGFR and KRAS mutations and altered c-Met gene copy numbers in primary non-small cell lung cancer and associated stage N2 lymph node-metastasis.
    Submit: New GeneRIF Correction See all (344)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Autism suseptibility 9

    Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.

    Hepatocellular carcinoma, childhood type

    Renal cell carcinoma, papillary, familial and somatic

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000236.2 NP_005179.2 CBL    BIND  PubMed Met interacts with Cbl. 
    NP_000236.2 GAB1    BIND  PubMed Met interacts with Gab1. 
    NP_000236.2 NP_000592.3 HGF    BIND  PubMed HGF interacts with Met. 
    NP_000236.2 NP_005532.2 INPP5D    BIND  PubMed MET (c-Met) interacts with INPP5D (SHIP-1). This interaction was modeled on a demonstrated interaction between human c-Met and SHIP-1 from an unspecified species. 
    NP_000236.2 NP_001558.2 INPPL1    BIND  PubMed MET (c-Met) interacts with INPPL1. This interaction was modeled on a demonstrated interaction between human c-Met and PIK3R1 from an unspecified species. 
    NP_000236.2 NP_000236.2 MET    BIND  PubMed The MET receptor dimerizes. 
    NP_000236.2 PIK3R1    BIND  PubMed MET (c-Met) interacts with PIK3R1. This interaction was modeled on a demonstrated interaction between human c-Met and PIK3R1 from an unspecified species. 
    P08581 Q99933 BAG1    HPRD  PubMed  
    P08581 P42574 CASP3    HPRD  PubMed  
    P08581 P22681 CBL    HPRD  PubMed  
    P08581 P21554 CNR1    HPRD  PubMed  
    P08581 P35222 CTNNB1    HPRD  PubMed  
    P08581 Q14247 CTTN    HPRD  PubMed  
    P08581 O43293 DAPK3    HPRD  PubMed  
    P08581 Q96EY1 DNAJA3    HPRD  PubMed  
    P08581 P00533 EGFR    HPRD  PubMed  
    P08581 P25445 FAS    HPRD  PubMed  
    P08581 Q13480 GAB1    HPRD  PubMed  
    P08581 Q92990 GLMN    HPRD  PubMed  
    P08581 P62993 GRB2    HPRD  PubMed  
    P08581 P14210 HGF    HPRD  PubMed  
    P08581 O14964 HGS    HPRD  PubMed  
    P08581 O00145 INPP5D    HPRD  PubMed  
    P08581 SHIP2 INPPL1    HPRD  PubMed  
    P08581 P16144 ITGB4    HPRD  PubMed  
    P08581 P08581 MET    HPRD  PubMed  
    P08581 P08581 MET    HPRD  PubMed  
    P08581 Mucin 20, cell surface associated MUC20    HPRD  PubMed  
    P08581 Q9H0N5 PCBD2    HPRD  PubMed  
    P08581 P27986 PIK3R1    HPRD  PubMed  
    P08581 P19174 PLCG1    HPRD  PubMed  
    P08581 O43157 PLXNB1    HPRD  PubMed  
    P08581 Q06124 PTPN11    HPRD  PubMed  
    P08581 P23467 PTPRB    HPRD  PubMed  
    P08581 Q12913 PTPRJ    HPRD  PubMed  
    P08581 RAN binding protein 10 RANBP10    HPRD  PubMed  
    P08581 Q96S59 RANBP9    HPRD  PubMed  
    P08581 P29353 SHC1    HPRD  PubMed  
    P08581 Q14683 SMC1A    HPRD  PubMed  
    P08581 O95295 SNAPIN    HPRD  PubMed  
    P08581 O60749 SNX2    HPRD  PubMed  
    P08581 Q96BD6 SPSB1    HPRD  PubMed  
    P08581 P12931 SRC    HPRD  PubMed  
    P08581 P40763 STAT3    HPRD  PubMed  
    P08581 P15498 VAV1    HPRD  PubMed  
    BioGRID:110391 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex 
    BioGRID:110391 BioGRID:107434 CDH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110391 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110391 BioGRID:108824 GAB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110391 BioGRID:115181 GAB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110391 BioGRID:116318 GLMN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110391 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110391 BioGRID:109330 HGF    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:110391 BioGRID:109848 INPPL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110391 BioGRID:117489 LRIG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110391 BioGRID:121657 RANBP10    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110391 BioGRID:115359 RANBP9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110391 BioGRID:119029 SH3KBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110391 BioGRID:112361 SHC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110391 BioGRID:112537 SOS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110391 BioGRID:112592 SRC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110391 BioGRID:112651 STAT3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110391 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem"Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligand...
    • Arf6 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Arf6 signaling events, organism-specific biosystem
      Arf6 signaling events
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem (from KEGG)
      Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
    • Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem (from KEGG)
      Epithelial cell signaling in Helicobacter pylori infection, conserved biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
    • FGF signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FGF signaling pathway, organism-specific biosystem
      FGF signaling pathway
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of retinoblastoma protein, organism-specific biosystem
      Regulation of retinoblastoma protein
    • Renal cell carcinoma, organism-specific biosystem (from KEGG)
      Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Renal cell carcinoma, conserved biosystem (from KEGG)
      Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Sema4D in semaphorin signaling, organism-specific biosystem (from REACTOME)
      Sema4D in semaphorin signaling, organism-specific biosystemSemaphorin 4D (Sema 4D/CD100) is an axon guidance molecule with two disulfide-linked 150-kDa subunits. SEMA4D is structurally defined by a conserved 500-amino acid extracellular domain with 16 cyste...
    • Sema4D mediated inhibition of cell attachment and migration, organism-specific biosystem (from REACTOME)
      Sema4D mediated inhibition of cell attachment and migration, organism-specific biosystemRepulsive Sema4D-Plexin-B1 signaling involves four GTPases, Rnd1, R-Ras, Rho and Rac1. Sema4D-Plexin-B1 binding promotes Rnd1-dependent activation of the plexin-B1 GAP domain and transient suppressio...
    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
      Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
    • Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    • Signaling events mediated by TCPTP, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by TCPTP, organism-specific biosystem
      Signaling events mediated by TCPTP
    • Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
      Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
      Stabilization and expansion of the E-cadherin adherens junction
    • Syndecan-1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-1-mediated signaling events, organism-specific biosystem
      Syndecan-1-mediated signaling events
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • a6b1 and a6b4 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      a6b1 and a6b4 Integrin signaling, organism-specific biosystem
      a6b1 and a6b4 Integrin signaling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    hepatocyte growth factor-activated receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    axon guidance TAS
    Traceable Author Statement
    more info
    		  
    branching morphogenesis of a tube IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    hepatocyte growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    hepatocyte growth factor receptor
    Names
    hepatocyte growth factor receptor
    SF receptor
    HGF receptor
    oncogene MET
    HGF/SF receptor
    proto-oncogene c-Met
    scatter factor receptor
    tyrosine-protein kinase Met
    met proto-oncogene tyrosine kinase
    NP_000236.2
    NP_001120972.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008996.1 RefSeqGene

      Range
      5001..130982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000245.2 → NP_000236.2  hepatocyte growth factor receptor isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AA278232, AI630755, BX648782, X54559
      Consensus CDS
      CCDS43636.1
      UniProtKB/TrEMBL
      A1L467
      UniProtKB/Swiss-Prot
      P08581
      Related
      ENSP00000380860, OTTHUMP00000069168, ENST00000397752, OTTHUMT00000141947
      Conserved Domains (9) summary
      cd01179
      Location:657 – 740
      Blast Score: 214
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:563 – 656
      Blast Score: 267
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:742 – 837
      Blast Score: 228
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1082 – 1343
      Blast Score: 1529
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      smart00630
      Location:52 – 487
      Blast Score: 719
      Sema; semaphorin domain
      cd11278
      Location:25 – 516
      Blast Score: 2448
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      pfam07714
      Location:1078 – 1337
      Blast Score: 1030
      Pkinase_Tyr; Protein tyrosine kinase
      cl02601
      Location:519 – 562
      Blast Score: 136
      PSI; Plexin repeat
      cl15674
      Location:838 – 934
      Blast Score: 97
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    2. NM_001127500.1 → NP_001120972.1  hepatocyte growth factor receptor isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC002543, AI630755, BC130420, BX648782, J02958
      Consensus CDS
      CCDS47689.1
      UniProtKB/TrEMBL
      A1L467
      UniProtKB/Swiss-Prot
      P08581
      Related
      ENSP00000317272, OTTHUMP00000024917, ENST00000318493, OTTHUMT00000059620
      Conserved Domains (8) summary
      cd01179
      Location:657 – 740
      Blast Score: 214
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:563 – 656
      Blast Score: 267
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1100 – 1361
      Blast Score: 1529
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      smart00630
      Location:52 – 487
      Blast Score: 719
      Sema; semaphorin domain
      cd11278
      Location:25 – 516
      Blast Score: 2449
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      pfam07714
      Location:1096 – 1355
      Blast Score: 1030
      Pkinase_Tyr; Protein tyrosine kinase
      cl02601
      Location:519 – 562
      Blast Score: 135
      PSI; Plexin repeat
      cl15674
      Location:742 – 855
      Blast Score: 199
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      116312459..116438440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      110678023..110804134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      115707906..115833890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC002080.1 AAB54047.1
    genomic AC002543.1 AAC60383.1
    genomic AC004416.1 AAF66137.2
    genomic CH236947.1 EAL24359.1
    genomic CH471070.1 EAW83507.1
      EAW83508.1
      EAW83509.1
      EAW83510.1
      EAW83511.1
    genomic M15325.1 AAA59585.1
    genomic M35073.1 AAA59589.1
    mRNA AA278232.1 None
    mRNA AB209898.1 BAD93135.1
    mRNA AF075090.1 None
    mRNA AI630755.1 None
    mRNA AK025784.1 None
    mRNA AK296974.1 BAG59517.1
    mRNA AK298552.1 BAG60748.1
    mRNA AK309532.1 None
    mRNA BC016592.1 None
    mRNA BC027979.1 AAH27979.1
    mRNA BC130420.1 AAI30421.1
    mRNA BX648782.1 None
    mRNA EU176015.1 ABX52004.1
    mRNA EU826567.1 ACF47603.1
    mRNA EU826568.1 ACF47604.1
    mRNA EU826569.1 ACF47605.1
    mRNA EU826570.1 ACF47606.1
    mRNA EU826571.1 ACF47607.1
    mRNA EU826572.1 ACF47608.1
    mRNA EU826573.1 ACF47609.1
    mRNA EU826574.1 ACF47610.1
    mRNA EU826575.1 ACF47611.1
    mRNA EU826576.1 ACF47612.1
    mRNA EU826577.1 ACF47613.1
    mRNA EU826579.1 ACF47615.1
    mRNA EU826580.1 ACF47616.1
    mRNA EU826581.1 ACF47617.1
    mRNA J02958.1 AAA59591.1
    mRNA M35074.1 AAA59590.1
    mRNA U11813.1 AAA68513.1
    mRNA X54559.1 CAB56793.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P08581.4 GenPept UniProtKB/Swiss-Prot:P08581
    Q14825 GenPept UniProtKB/TrEMBL:Q14825
    Q59EB3 GenPept UniProtKB/TrEMBL:Q59EB3
    Q9UEJ3 GenPept UniProtKB/TrEMBL:Q9UEJ3
    Q9UMU9 GenPept UniProtKB/TrEMBL:Q9UMU9
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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