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LRP4 LDL receptor related protein 4 [ Gallus gallus (chicken) ]

Gene ID: 423189, updated on 3-Apr-2024

Summary

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Symbol
LRP4provided by CGNC
Full Name
LDL receptor related protein 4provided by CGNC
Primary source
CGNC:6284
See related
Ensembl:ENSGALG00010022929
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
42
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (22825802..22920775)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (22793366..22888303)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene damage specific DNA binding protein 2 Neighboring gene protein kinase C and casein kinase substrate in neurons 3 Neighboring gene C11orf49 homolog Neighboring gene ADP ribosylation factor GTPase activating protein 2 Neighboring gene cytoskeleton associated protein 5 Neighboring gene small nucleolar RNA SNORD67 Neighboring gene coagulation factor II, thrombin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway involved in somitogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor-mediated endocytosis involved in cholesterol transport IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 4
Names
low density lipoprotein receptor-related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    22825802..22920775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046942516.1 → XP_046798472.1  low-density lipoprotein receptor-related protein 4 isoform X3

  2. XM_046942517.1 → XP_046798473.1  low-density lipoprotein receptor-related protein 4 isoform X3

  3. XM_004941584.5 → XP_004941641.2  low-density lipoprotein receptor-related protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZY49
    Related
    ENSGALP00010033786.1, ENSGALT00010055807.1
    Conserved Domains (5) summary
    smart00135
    Location:516 → 556
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:406 → 445
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:281 → 315
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:786 → 823
    NHL; NHL repeat [structural motif]
    cl18310
    Location:786 → 981
    NHL; NHL repeat unit of beta-propeller proteins

  4. XM_421114.8 → XP_421114.5  low-density lipoprotein receptor-related protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZY49, A0A8V0ZY54
    Related
    ENSGALP00010033829.1, ENSGALT00010055880.1
    Conserved Domains (5) summary
    smart00135
    Location:516 → 556
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:406 → 445
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:281 → 315
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:785 → 822
    NHL; NHL repeat [structural motif]
    cl18310
    Location:785 → 980
    NHL; NHL repeat unit of beta-propeller proteins

  5. XM_004941585.5 → XP_004941642.2  low-density lipoprotein receptor-related protein 4 isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZY19
    Related
    ENSGALP00010033794.1, ENSGALT00010055824.1
    Conserved Domains (5) summary
    smart00135
    Location:516 → 556
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:406 → 445
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:281 → 315
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:786 → 823
    NHL; NHL repeat [structural motif]
    cl18310
    Location:786 → 981
    NHL; NHL repeat unit of beta-propeller proteins

  6. XM_040702001.2 → XP_040557935.1  low-density lipoprotein receptor-related protein 4 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZTE6
    Conserved Domains (5) summary
    smart00135
    Location:439 → 479
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:329 → 368
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:204 → 238
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:709 → 746
    NHL; NHL repeat [structural motif]
    cl18310
    Location:709 → 904
    NHL; NHL repeat unit of beta-propeller proteins

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    22793366..22888303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046919520.1 → XP_046775476.1  low-density lipoprotein receptor-related protein 4 isoform X3

  2. XM_046919521.1 → XP_046775477.1  low-density lipoprotein receptor-related protein 4 isoform X3

  3. XM_040673623.2 → XP_040529557.1  low-density lipoprotein receptor-related protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZTE6
    Conserved Domains (5) summary
    smart00135
    Location:517 → 557
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:407 → 446
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:282 → 316
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:787 → 824
    NHL; NHL repeat [structural motif]
    cl18310
    Location:787 → 982
    NHL; NHL repeat unit of beta-propeller proteins

  4. XM_040673624.2 → XP_040529558.1  low-density lipoprotein receptor-related protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZTE6
    Conserved Domains (5) summary
    smart00135
    Location:517 → 557
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:407 → 446
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:282 → 316
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:786 → 823
    NHL; NHL repeat [structural motif]
    cl18310
    Location:786 → 981
    NHL; NHL repeat unit of beta-propeller proteins

  5. XM_040673626.2 → XP_040529560.1  low-density lipoprotein receptor-related protein 4 isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZY19
    Conserved Domains (5) summary
    smart00135
    Location:517 → 557
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:407 → 446
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:282 → 316
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:787 → 824
    NHL; NHL repeat [structural motif]
    cl18310
    Location:787 → 982
    NHL; NHL repeat unit of beta-propeller proteins

  6. XM_040673625.2 → XP_040529559.1  low-density lipoprotein receptor-related protein 4 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZTE6
    Conserved Domains (5) summary
    smart00135
    Location:439 → 479
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:329 → 368
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:204 → 238
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:709 → 746
    NHL; NHL repeat [structural motif]
    cl18310
    Location:709 → 904
    NHL; NHL repeat unit of beta-propeller proteins
Nucleotide Protein Strain
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