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PRIMPOL primase and DNA directed polymerase [ Gallus gallus (chicken) ]

Gene ID: 422549, updated on 3-Apr-2024

Summary

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Symbol
PRIMPOLprovided by CGNC
Full Name
primase and DNA directed polymeraseprovided by CGNC
Primary source
CGNC:8078
See related
Ensembl:ENSGALG00010007085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CCDC111
Orthologs
human mouse all
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Genomic context

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See PRIMPOL in Genome Data Viewer
Location:
chromosome: 4
Exon count:
13
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (39056534..39072577, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (39004164..39020200, complement)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107051755 Neighboring gene uncharacterized LOC121110733 Neighboring gene acyl-CoA synthetase long-chain family member 1 Neighboring gene helt bHLH transcription factor Neighboring gene centromere protein U Neighboring gene caspase 3 Neighboring gene uncharacterized LOC121110735 Neighboring gene interferon regulatory factor 2 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides. Kobayashi K, et al. Cell Cycle, 2016 Aug 2. PMID 27230014, Free PMC Article
  2. PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells. Schiavone D, et al. Mol Cell, 2016 Jan 7. PMID 26626482, Free PMC Article
  3. R-loop formation during S phase is restricted by PrimPol-mediated repriming. Šviković S, et al. EMBO J, 2019 Feb 1. PMID 30478192, Free PMC Article
  4. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PrimPol's repriming activity plays a central role in reinitiating replication downstream from chain-terminating nucleoside analogs and other specific DNA lesions.
    Title: Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides.
  2. Implicate PrimPol in promoting restart of DNA synthesis downstream of, but closely coupled to, G4 replication impediments.
    Title: PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA primase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in error-prone translesion synthesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitochondrial DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in replication fork processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to UV IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA-directed primase/polymerase protein
Names
coiled-coil domain containing 111
primase and polymerase (DNA-directed)
NP_001026308.3
XP_040554866.1
XP_046771996.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031137.4 → NP_001026308.3  DNA-directed primase/polymerase protein

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000073
    UniProtKB/TrEMBL
    A0A8V0XWS0
    Related
    ENSGALP00010009459.1, ENSGALT00010016817.1
    Conserved Domains (1) summary
    pfam03121
    Location:407 → 469
    Herpes_UL52; Herpesviridae UL52/UL70 DNA primase

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    39056534..39072577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040698932.2 → XP_040554866.1  DNA-directed primase/polymerase protein isoform X1

    UniProtKB/TrEMBL
    A0A8V0XWS0
    Conserved Domains (1) summary
    pfam03121
    Location:309 → 371
    Herpes_UL52; Herpesviridae UL52/UL70 DNA primase

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    39004164..39020200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046916040.1 → XP_046771996.1  DNA-directed primase/polymerase protein isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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