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MEOX2 mesenchyme homeobox 2 [ Homo sapiens (human) ]

Gene ID: 4223, updated on 12-May-2016
Official Symbol
MEOX2provided by HGNC
Official Full Name
mesenchyme homeobox 2provided by HGNC
Primary source
HGNC:HGNC:7014
See related
Ensembl:ENSG00000106511 HPRD:02760; MIM:600535; Vega:OTTHUMG00000152390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAX; MOX2
Summary
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]
Orthologs
Location:
7p22.1-p21.3
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (15611212..15686683, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (15650837..15726308, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene general transcription factor IIIA pseudogene 5 Neighboring gene uncharacterized LOC105375165 Neighboring gene alkylglycerol monooxygenase Neighboring gene uncharacterized LOC105375166 Neighboring gene MEOX2 antisense RNA 1 (head to head) Neighboring gene ribosomal protein L36a pseudogene 26

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
blood circulation TAS
Traceable Author Statement
more info
PubMed 
limb development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
palate development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
somite specification IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
homeobox protein MOX-2
Names
growth arrest-specific homeobox

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032988.1 RefSeqGene

    Range
    5001..80472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005924.4NP_005915.2  homeobox protein MOX-2

    See identical proteins and their annotated locations for NP_005915.2

    Status: REVIEWED

    Source sequence(s)
    BC017021, BQ025060, DA586635
    Consensus CDS
    CCDS34605.1
    UniProtKB/Swiss-Prot
    P50222
    Related
    ENSP00000262041, OTTHUMP00000201586, ENST00000262041, OTTHUMT00000326058
    Conserved Domains (2) summary
    COG5576
    Location:160284
    COG5576; Homeodomain-containing transcription factor [Transcription]
    cd00086
    Location:188246
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    15611212..15686683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    15650236..15725903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)