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GEN1 GEN1, Holliday junction 5' flap endonuclease [ Gallus gallus (chicken) ]

Gene ID: 421951, updated on 5-Mar-2024

Summary

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Symbol
GEN1provided by CGNC
Full Name
GEN1, Holliday junction 5' flap endonucleaseprovided by CGNC
Primary source
CGNC:12330
See related
Ensembl:ENSGALG00010002376
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
18
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (99939759..99958150)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (99765272..99783677)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene visinin like 1 Neighboring gene structural maintenance of chromosomes 6 Neighboring gene mesogenin 1 Neighboring gene zona pellucida protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 5'-flap endonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables four-way junction DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
flap endonuclease GEN homolog 1
Names
Gen endonuclease homolog 1
Gen homolog 1, endonuclease

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    99939759..99958150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_419963.8 → XP_419963.3  flap endonuclease GEN homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XF57
    Related
    ENSGALP00010003270.1, ENSGALT00010005431.1
    Conserved Domains (2) summary
    cd09869
    Location:1 → 191
    PIN_GEN1; PIN domain of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    cl22433
    Location:195 → 338
    H3TH_StructSpec-5'-nucleases; H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination

  2. XM_004935777.5 → XP_004935834.1  flap endonuclease GEN homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0X5F3, A0A8V0XF57
    Related
    ENSGALP00010003272.1, ENSGALT00010005433.1
    Conserved Domains (2) summary
    cd09869
    Location:1 → 191
    PIN_GEN1; PIN domain of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    cl22433
    Location:195 → 338
    H3TH_StructSpec-5'-nucleases; H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination

  3. XM_040697615.1 → XP_040553549.1  flap endonuclease GEN homolog 1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0XF57
    Conserved Domains (3) summary
    cd09869
    Location:1 → 126
    PIN_GEN1; FEN-like PIN domains of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    pfam18704
    Location:349 → 405
    Chromo_2; Chromatin organization modifier domain 2
    cl22433
    Location:130 → 273
    H3TH_StructSpec-5'-nucleases; H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination

  4. XM_004935780.4 → XP_004935837.1  flap endonuclease GEN homolog 1 isoform X3

    See identical proteins and their annotated locations for XP_004935837.1

    UniProtKB/TrEMBL
    A0A8V0XF57
    Conserved Domains (3) summary
    cd09869
    Location:1 → 126
    PIN_GEN1; FEN-like PIN domains of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    pfam18704
    Location:349 → 405
    Chromo_2; Chromatin organization modifier domain 2
    cl22433
    Location:130 → 273
    H3TH_StructSpec-5'-nucleases; H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    99765272..99783677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040666774.2 → XP_040522708.1  flap endonuclease GEN homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XF57
    Conserved Domains (2) summary
    cd09869
    Location:2 → 191
    PIN_GEN1; FEN-like PIN domains of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    cl22433
    Location:195 → 338
    H3TH_StructSpec-5'-nucleases; H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination

  2. XM_040666773.2 → XP_040522707.1  flap endonuclease GEN homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XF57
    Conserved Domains (2) summary
    cd09869
    Location:2 → 191
    PIN_GEN1; FEN-like PIN domains of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    cl22433
    Location:195 → 338
    H3TH_StructSpec-5'-nucleases; H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination

  3. XM_040666775.1 → XP_040522709.1  flap endonuclease GEN homolog 1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0XF57
    Conserved Domains (2) summary
    cd09869
    Location:1 → 126
    PIN_GEN1; FEN-like PIN domains of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    cl22433
    Location:130 → 273
    H3TH_StructSpec-5'-nucleases; H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination

  4. XM_040666776.1 → XP_040522710.1  flap endonuclease GEN homolog 1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0XF57
    Conserved Domains (2) summary
    cd09869
    Location:1 → 126
    PIN_GEN1; FEN-like PIN domains of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    cl22433
    Location:130 → 273
    H3TH_StructSpec-5'-nucleases; H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination
Nucleotide Protein
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