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CG5265 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42074, updated on 4-Apr-2024

Summary

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Official Symbol
CG5265provided by FlyBase
Primary source
FLYBASE:FBgn0038486
Locus tag
Dmel_CG5265
See related
AllianceGenome:FB:FBgn0038486
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CrAT; CRAT; Dmel\CG5265
Summary
Predicted to enable carnitine O-acetyltransferase activity. Predicted to be involved in carnitine metabolic process, CoA-linked and fatty acid metabolic process. Predicted to be active in peroxisome. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human CRAT (carnitine O-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
89F1-89F1; 3-60 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17138999..17141168)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12964721..12966890)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TweedleW Neighboring gene mann-cup

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. L-Carnitine in Drosophila: A Review. Carillo MR, et al. Antioxidants (Basel), 2020 Dec 21. PMID 33371457, Free PMC Article
  2. Age-dependent chromosomal distribution of male-biased genes in Drosophila. Zhang YE, et al. Genome Res, 2010 Nov. PMID 20798392, Free PMC Article
  3. A cautionary note for retrocopy identification: DNA-based duplication of intron-containing genes significantly contributes to the origination of single exon genes. Zhang YE, et al. Bioinformatics, 2011 Jul 1. PMID 21551137, Free PMC Article
  4. Comparative genomics reveals a constant rate of origination and convergent acquisition of functional retrogenes in Drosophila. Bai Y, et al. Genome Biol, 2007. PMID 17233920, Free PMC Article
  5. Parent genes of retrotransposition-generated gene duplicates in Drosophila melanogaster have distinct expression profiles. Langille MG, et al. Genomics, 2007 Sep. PMID 17628393

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine O-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carnitine O-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in carnitine metabolic process, CoA-linked IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG5265-PA
carnitine acetyltransferase
NP_650605.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17138999..17141168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142348.2 → NP_650605.1  uncharacterized protein Dmel_CG5265 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650605.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEM4
    Related
    FBpp0082848
    Conserved Domains (1) summary
    pfam00755
    Location:49 → 623
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VEM4 Q9VEM4

Gene LinkOut

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