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    MDM2 Mdm2 p53 binding protein homolog (mouse) [ Homo sapiens ]

    Gene ID: 4193, updated on 14-Feb-2012
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    Summary

    Official Symbol
    MDM2provided by HGNC
    Official Full Name
    Mdm2 p53 binding protein homolog (mouse)provided by HGNC
    Primary source
    HGNC:6973
    See related
    Ensembl:ENSG00000135679; HPRD:01272; MIM:164785; Vega:OTTHUMG00000142827
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HDMX; hdm2; ACTFS
    Summary
    This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    12q14.3-q15
    Sequence :
    Chromosome: 12; NC_000012.11 (69201971..69239212)
    See MDM2 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase-activated protein kinase 2 pseudogene Neighboring gene UPF0485 protein C1orf144 homolog Neighboring gene carboxypeptidase M Neighboring gene cleavage and polyadenylation specific factor 6, 68kDa Neighboring gene microRNA 1279

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. Lim SO, et al. BMC Biol, 2011 Nov 30. PMID 22128911.
    2. Abnormal MDMX degradation in tumor cells due to ARF deficiency. Li X, et al. Oncogene, 2011 Nov 28. PMID 22120712.
    3. Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination. Bhatt P, et al. FEBS J, 2012 Feb. PMID 22103682.
    4. Regulation of p53 stability and function by the deubiquitinating enzyme USP42. Hock AK, et al. EMBO J, 2011 Nov 15. PMID 22085928.
    5. MDM2 regulates vascular endothelial growth factor mRNA stabilization in hypoxia. Zhou S, et al. Mol Cell Biol, 2011 Dec. PMID 21986500.

    See all (841) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specific breast tumor subgroups
      Title: Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specific breast tumor subgroups.
    2. It was shown that high level of Ebp1 expression led to enhancee HDM2 phosphorylation by Akt and inhibited the self-ubiquitination of HDM2 by up-regulation of Akt activity.
      Title: Long isoform of ErbB3 binding protein, p48, mediates protein kinase B/Akt-dependent HDM2 stabilization and nuclear localization.
    3. turnover of p21 was independent of the SCF (skp2) E3 ligase but could be inhibited, at least in part, by reducing hdm2, although this depended on the cell type studied.
      Title: Hdm2- and proteasome-dependent turnover limits p21 accumulation during S phase.
    4. DNA damage promotes MDM2 phosphorylation near the RING domain and inhibits MDM2 RING domain dimerization.
      Title: Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.
    5. SPARC has a cell-autonomous survival activity, which requires Akt-dependent regulation of p53
      Title: SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival.
    6. MDM2 plays a p53-independent role in the regulation of vascular endothelial growth factor, which may promote tumor growth and metastasis.
      Title: MDM2 regulates vascular endothelial growth factor mRNA stabilization in hypoxia.
    7. These data suggest that IRTKS is a novel regulator of p53, modulating low level of MDM2-mediated p53 ubiquitination in unstressed cells.
      Title: Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination.
    8. Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation
      Title: Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation.
    9. A restricted pattern of p53 overexpression is preferentially associated with microsatellite instability high phenotype. Its association with concomitant murine double minute 2 overexpression suggests an alternative mechanism of p53 pathway deregulation.
      Title: Distinctive patterns of p53 protein expression and microsatellite instability in human colorectal cancer.
    10. this is the first study to show that a variant genotype of p53 Arg72Pro or MDM2 SNP309 may modify the arsenic-related RCC risk even in a non-obvious arsenic exposure area.
      Title: The polymorphisms of P53 codon 72 and MDM2 SNP309 and renal cell carcinoma risk in a low arsenic exposure area.
    Submit: New GeneRIF Correction See all (603)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Accelerated tumor formation, susceptibility to

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat Ubiquitination of HIV-1 Tat by Hdm2 is required for efficient replication of HIV-1, indicating Hdm2 regulates Tat function and is a Tat co-activator PubMed
    tat Hdm2 interacts directly with HIV-1 Tat and ubiquitinates Tat on amino acid residue Lys71 PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    AF527840.1 NP_000537.2 TP53    BIND  PubMed p53 interacts with the hdm2 promoter. 
    AF527840.1     BIND  PubMed p53 tetramer interacts with Mdm2 promoter. 
    NC_000012.9 NP_612482.2 SP1    BIND  PubMed SP1 interacts with the MDM2 intronic promoter. 
    NC_000012.9 NP_000537.2 TP53    BIND  PubMed p53 interacts with mdm2 promoter. 
    NC_000012.9 NP_000537.2 TP53    BIND  PubMed TP53 (p53) interacts with the MDM2-promoter. 
    NP_002383.1 NP_005154.1 AKT1    BIND  PubMed HDM2 interacts with and is phosphorylated by Akt. 
    NP_002383.1 NP_478102.1 CDKN2A    BIND  PubMed Mdm2 interacts with p14ARF. 
    NP_002383.1 NP_478102.1 CDKN2A    BIND  PubMed p14 interacts with MDM2. 
    NP_002383.1 NP_478102.1 CDKN2A    BIND  PubMed MDM2 interacts with p14ARF 
    NP_002383.1 NP_002383.1 MDM2    BIND  PubMed Mdm2 auto-ubiquitinates. This interaction was modeled on a demonstrated interaction between Mdm2 from an unspecified species. 
    NP_002383.1 NP_002383.1 MDM2    BIND  PubMed An unspecified isoform of MDM2 interacts and ubiquitinates itself intermolecularly. This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species. 
    NP_002383.1 NP_002383.1 MDM2    BIND  PubMed Mdm2 ubiquitinates itself. 
    NP_002383.1 NP_002383.1 MDM2    BIND  PubMed Hdm2 interacts with Hdm2. 
    NP_002383.1 NP_002384.1 MDM4    BIND  PubMed Mdm2 interacts with Hdmx. 
    NP_002383.1 NP_002384.1 MDM4    BIND  PubMed MDM2 interacts with MDM4 (MDMX). 
    NP_002383.1 NP_002666.1 PML    BIND  PubMed PML interacts with Mdm2. 
    NP_002383.1 PSMD10    BIND  PubMed An unspecified isoform of gankyrin interacts with Mdm2. 
    NP_002383.1 NP_000312.1 RB1    BIND  PubMed Rb interacts with MDM2. 
    NP_002383.1 NP_000966.2 RPL11    BIND  PubMed L11 interacts with Hdm2. 
    NP_002383.1 NP_000537.2 TP53    BIND  PubMed Mdm2 interacts with p53. 
    NP_002383.1 NP_000537.2 TP53    BIND  PubMed An unspecified isoform of MDM2 interacts with and ubiquitinates p53. This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species and human p53. 
    NP_002383.1 NP_000537.2 TP53    BIND  PubMed An unspecified isoform of Mdm2 ubiquitinates p53. This interaction was modeled on a demonstrated interaction between Mdm2 and p53 both from an unspecified species. 
    NP_002383.1 NP_000537.2 TP53    BIND  PubMed Mdm2 ubiquitinates p53. 
    NP_002383.1 NP_000537.2 TP53    BIND  PubMed Mdm2 interacts with p53. 
    NP_002383.1 NP_000537.2 TP53    BIND  PubMed Mdm2 interacts with p53. 
    NP_002383.1 NP_000537.2 TP53    BIND  PubMed Mdm2 interacts with and ubiquitinates p53 
    NP_002383.1 NP_000537.2 TP53    BIND  PubMed Mdm2 ubiquitinates p53. This interaction was modeled on a demonstrated interaction between mouse Mdm2 and human p53. 
    NP_002383.1 NP_000537.2 TP53    BIND  PubMed Hdm2 interacts with p53. 
    NP_002383.1 NP_003461.1 USP7    BIND  PubMed Mdm2 interacts with HAUSP. This interaction was modeled on a demonstrated interaction between Mdm2 from an unspecified species and human HAUSP. 
    NP_002383.1 NP_003394.1 YY1    BIND  PubMed YY1 interacts with Hdm2. 
    Q00987 P00519 ABL1    HPRD  PubMed  
    Q00987 P25098 ADRBK1    HPRD  PubMed  
    Q00987 P31749 AKT1    HPRD  PubMed  
    Q00987 P10275 AR    HPRD  PubMed  
    Q00987 P32121 ARRB2    HPRD  PubMed  
    Q00987 Q13315 ATM    HPRD  PubMed  
    Q00987 P42574 CASP3    HPRD  PubMed  
    Q00987 P51959 CCNG1    HPRD  PubMed  
    Q00987 Q8N726 CDKN2A    HPRD  PubMed  
    Q00987 O96017 CHEK2    HPRD  PubMed  
    Q00987 Q92793 CREBBP    HPRD  PubMed  
    Q00987 P56545 CTBP2    HPRD  PubMed  
    Q00987 Q9UER7 DAXX    HPRD  PubMed  
    Q00987 EID1 EID1    HPRD  PubMed  
    Q00987 Q09472 EP300    HPRD  PubMed  
    Q00987 P03372 ESR1    HPRD  PubMed  
    Q00987 P29084 GTF2E2    HPRD  PubMed  
    Q00987 Q13547 HDAC1    HPRD  PubMed  
    Q00987 Q16665 HIF1A    HPRD  PubMed  
    Q00987 Q9H2X6 HIPK2    HPRD  PubMed  
    Q00987 P08069 IGF1R    HPRD  PubMed  
    Q00987 Junction mediating and regulatory protein JMY    HPRD  PubMed  
    Q00987 Q92831 KAT2B    HPRD  PubMed  
    Q00987 Q92993 KAT5    HPRD  PubMed  
    Q00987 O15151 MDM4    HPRD  PubMed  
    Q00987 Q15648 MED1    HPRD  PubMed  
    Q00987 Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa MTBP    HPRD  PubMed  
    Q00987 P06748 NPM1    HPRD  PubMed  
    Q00987 P04150 NR3C1    HPRD  PubMed  
    Q00987 P49757 NUMB    HPRD  PubMed  
    Q00987 O75925 PIAS1    HPRD  PubMed  
    Q00987 Q8NG27 PJA1    HPRD  PubMed  
    Q00987 P29590 PML    HPRD  PubMed  
    Q00987 Q07864 POLE    HPRD  PubMed  
    Q00987 O75832 PSMD10    HPRD  PubMed  
    Q00987 P49792 RANBP2    HPRD  PubMed  
    Q00987 P06400 RB1    HPRD  PubMed  
    Q00987 P62913 RPL11    HPRD  PubMed  
    Q00987 P46777 RPL5    HPRD  PubMed  
    Q00987 P63165 SUMO1    HPRD  PubMed  
    Q00987 P21675 TAF1    HPRD  PubMed  
    Q00987 P20226 TBP    HPRD  PubMed  
    Q00987 O15273 TCAP    HPRD  PubMed  
    Q00987 P04637 TP53    HPRD  PubMed  
    Q00987 O15350 TP73    HPRD  PubMed  
    Q00987 Q99816 TSG101    HPRD  PubMed  
    Q00987 Ubiquitin B UBB    HPRD  PubMed  
    Q00987 P49459 UBE2A    HPRD  PubMed  
    Q00987 Q9NRR5 UBQLN4    HPRD  PubMed  
    Q00987 O75604 USP2    HPRD  PubMed  
    Q00987 Q93009 USP7    HPRD  PubMed  
    BioGRID:110358 BioGRID:106543 ABL1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:110358 BioGRID:106663 ADRB2    BioGRID  PubMed Biochemical Activity 
    BioGRID:110358 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110358 BioGRID:106825 APEX1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110358 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex 
    BioGRID:110358 BioGRID:106900 ARR3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:106901 ARRB1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110358 BioGRID:106902 ARRB2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization 
    BioGRID:110358 BioGRID:106957 ATF3    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:110358 BioGRID:121017 BAIAP2L1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:110358 BioGRID:120308 BANP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:107224 CA11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:107285 CASP2    BioGRID  PubMed Biochemical Activity 
    BioGRID:110358 BioGRID:120867 CCAR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:107340 CCNG1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:107434 CDH1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-Western 
    U24170.1 CDKN1A    BIND  PubMed Mdm2 interacts with the p21 promoter. 
    BioGRID:110358 BioGRID:107460 CDKN1A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    NP_478102.1 CDKN2A    BIND  PubMed p14ARF interacts with an unspecified isoform of Mdm2. 
    BioGRID:110358 BioGRID:107463 CDKN2A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid 
    BioGRID:110358 BioGRID:116369 CHEK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:110358 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:110358 BioGRID:107836 CSNK1A1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:107837 CSNK1D    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110358 BioGRID:107869 CTBP1    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:110358 BioGRID:107870 CTBP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:198654 Cdkn2a    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110358 BioGRID:107985 DAXX    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:115776 DDX17    BioGRID  PubMed Affinity Capture-Luminescence 
    NP_055577.1 DHCR24    BIND  PubMed Seladin-1 interacts with an unspecified isoform of Mdm2. 
    BioGRID:110358 BioGRID:108065 DHFR    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:110358 BioGRID:114023 DYRK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110358 BioGRID:108201 E2F1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:122908 EHMT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:117243 EID1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:110358 BioGRID:108377 ERBB3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:108403 ESR1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110358 BioGRID:116887 FBXW11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:108577 FKBP3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:108597 FOXO1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:108598 FOXO3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:110449 FOXO4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110358 BioGRID:115237 G3BP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:108895 GATA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:109040 GNAS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:117690 GNL3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:120037 GNL3L    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:110358 BioGRID:124937 GORAB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:109215 GTF2E1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110358 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:110358 BioGRID:115860 HEXIM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:109338 HIF1A    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:110358 BioGRID:113945 HIST2H2BE    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    NP_003484.1 HIST3H3    BIND  PubMed Mdm2 interacts with H3. 
    BioGRID:110358 BioGRID:113895 HIST3H3    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    NP_778224.1 HIST4H4    BIND  PubMed Mdm2 interacts with H4. 
    BioGRID:110358 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:109701 IGF1R    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110358 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression; Reconstituted Complex 
    BioGRID:110358 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:110114 LAMP2    BioGRID  PubMed Affinity Capture-Western 
    NP_004750.1 MAPKAPK2    BIND  PubMed MDM2 (HDM2) interacts with MAPKAPK2 isoform 1 (MK2). This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species, and human MAPKAPK2. 
    NP_116584.2 MAPKAPK2    BIND  PubMed MDM2 (HDM2) interacts with MAPKAPK2 (MK2) isoform 2. This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species, and human MAPKAPK2. 
    BioGRID:110358 BioGRID:115014 MDC1    BioGRID  PubMed Protein-peptide 
    BioGRID:110358 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:110358 BioGRID:110359 MDM4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:110358 BioGRID:114562 MTA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:117988 MTBP    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid 
    BioGRID:110358 BioGRID:201373 Mdm4    BioGRID  PubMed Biochemical Activity 
    BioGRID:110358 BioGRID:110771 NCL    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:110913 NOTCH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:110917 NOTCH4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:109165 NR3C1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:114202 NUMB    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:110358 BioGRID:111075 PA2G4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:120335 PAK1IP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:111170 PDE4D    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110358 BioGRID:114682 PDLIM7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:110358 BioGRID:114065 PPM1D    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:111661 PSMA7    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:110358 BioGRID:111673 PSMC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:111675 PSMC3    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:110358 BioGRID:111678 PSMC5    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:110358 BioGRID:111679 PSMC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:111680 PSMD1    BioGRID  PubMed Co-fractionation 
    BioGRID:110358 BioGRID:111688 PSMD10    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:111681 PSMD2    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:110358 BioGRID:111683 PSMD4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:110358 BioGRID:115492 PSME3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:111719 PTK2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110358 BioGRID:127225 PYHIN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:111823 RAD23A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:116356 RASSF1    BioGRID  PubMed Affinity Capture-Western 
    NP_000312.1 RB1    BIND  PubMed Rb interacts with Mdm2. 
    BioGRID:110358 BioGRID:111860 RB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:111865 RBBP6    BioGRID  PubMed Affinity Capture-Western 
    NP_005602.2 RBL2    BIND  PubMed p130 interacts with Mdm2. 
    BioGRID:110358 BioGRID:117406 RCHY1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:122136 RFWD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:120460 RFWD3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:111955 RN5S1@    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:110358 BioGRID:112055 RPL11    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:110358 BioGRID:114752 RPL23    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:110358 BioGRID:112073 RPL26    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:110358 BioGRID:112045 RPL5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:110358 BioGRID:112146 RPS27    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:112147 RPS27A    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:110358 BioGRID:119256 RPS27L    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:112102 RPS3    BioGRID  PubMed Affinity Capture-Western; FRET; Reconstituted Complex 
    BioGRID:110358 BioGRID:112112 RPS6KB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:112115 RPS7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:119071 RRM2B    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110358 BioGRID:107312 RUNX3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:116997 RYBP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:112179 S100A1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110358 BioGRID:112181 S100A2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110358 BioGRID:112183 S100A4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110358 BioGRID:112185 S100A6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110358 BioGRID:112193 S100B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110358 BioGRID:117594 SENP3    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:110358 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:115823 SIVA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:121411 SMURF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:112499 SNAI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:112542 SOX4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:112706 SUV39H1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:112735 TAF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:112771 TBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110358 BioGRID:124337 TBRG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:112874 TERT    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    NP_000537.2 TP53    BIND  PubMed p53 interacts with unspecified isoform of Mdm2. 
    NP_000537.2 TP53    BIND  PubMed hdm2 interacts with p53. This interaction was modeled on a demonstrated interaction between hdm2 and p53 both from an unspecified species. 
    NP_000537.2 TP53    BIND  PubMed p53 interacts with Mdm2. 
    NP_000537.2 TP53    BIND  PubMed p53 interacts with mdm2. This interaction was modelled on a demonstrated interaction between human p53 and mdm2 from an unspecified species. 
    NP_000537.2 TP53    BIND  PubMed Mdm2 interacts with and ubiquitinates p53. 
    NP_000537.2 TP53    BIND  PubMed An unspecified isoform of HDM2 interacts with p53. This interaction was modelled on a demonstrated interaction between human HDM2 and p53 from an unspecified species. 
    NP_000537.2 TP53    BIND  PubMed An unspecifed isoform of Mdm2 interacts with p53. 
    NP_000537.2 TP53    BIND  PubMed MDM2 (HDM2) interacts with TP53 (p53). This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species, and human TP53. 
    NP_000537.2 TP53    BIND  PubMed p53 interacts with Mdm2. 
    NP_000537.2 TP53    BIND  PubMed HDM-2 interacts with p53 
    NP_000537.2 TP53    BIND  PubMed p53 interacts with and is ubiquitinated by Mdm2. 
    BioGRID:110358 BioGRID:114181 TP63    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110358 BioGRID:113014 TP73    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:115501 TRIM13    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:111919 TRIM27    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110358 BioGRID:115457 TRIM28    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110358 BioGRID:113102 TSG101    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:204323 Trp53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:113167 UBE2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:110358 BioGRID:113175 UBE2G2    BioGRID  PubMed Two-hybrid 
    BioGRID:110358 BioGRID:113177 UBE2I    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:127156 UBE2U    BioGRID  PubMed Two-hybrid 
    BioGRID:110358 BioGRID:122419 UBE2Z    BioGRID  PubMed Two-hybrid 
    BioGRID:110358 BioGRID:115566 UBE4B    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:110358 BioGRID:113192 UCHL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:119697 UIMC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:114554 USP10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:114553 USP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110358 BioGRID:123904 USP42    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:113622 USP7    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Co-fractionation; Protein-peptide; Reconstituted Complex 
    BioGRID:110358 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:110358 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:113360 YY1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110358 BioGRID:122868 ZNF668    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110358 BioGRID:1205541 tat    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110358 BioGRID:1205539 vif    BioGRID  PubMed Affinity Capture-Western 
    P04614     BIND  PubMed Tat interacts with an unspecified isoform of MDM2 (Hdm2). 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • AKT phosphorylates targets in the cytosol, organism-specific biosystem (from REACTOME)
      AKT phosphorylates targets in the cytosol, organism-specific biosystemFollowing activation, AKT can phosphorylate an array of target proteins in the cytoplasm, many of which are involved in cell survival control. Phosphorylation of TSC2 feeds positively to the TOR kina...
    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora A signaling, organism-specific biosystem
      Aurora A signaling
    • Bladder cancer, organism-specific biosystem (from KEGG)
      Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, conserved biosystem (from KEGG)
      Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
      Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
    • Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
      Downstream signaling of activated FGFR, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
      ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • ErbB4 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      ErbB4 signaling events, organism-specific biosystem
      ErbB4 signaling events
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • G1/S DNA Damage Checkpoints, organism-specific biosystem (from REACTOME)
      G1/S DNA Damage Checkpoints, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding ...
    • GAB1 signalosome, organism-specific biosystem (from REACTOME)
      GAB1 signalosome, organism-specific biosystemGAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
      Glucocorticoid receptor regulatory network, organism-specific biosystem
      Glucocorticoid receptor regulatory network
    • Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem (from REACTOME)
      Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystemExcitatory synaptic transmission in the brain is carried out by glutamate receptors through the activation of both ionotropic and metabotropic receptors. Ionotropic glutamate receptors are of three ...
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
      Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
    • PI-3K cascade, organism-specific biosystem (from REACTOME)
      PI-3K cascade, organism-specific biosystemThe ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which i...
    • PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB2 signaling, organism-specific biosystemERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated t...
    • PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB4 signaling, organism-specific biosystemThe CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1 (Kaushansky et al. 2008, Cohen e...
    • PI3K/AKT activation, organism-specific biosystem (from REACTOME)
      PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
    • PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
      PIP3 activates AKT signaling, organism-specific biosystemSignaling by AKT is one of the key outcomes of activation of receptor tyrosine kinases (RTKs). Following ligand binding and autophosphorylation, RTKs recruit the 85 kDa regulatory subunit of PI3K (PI...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Regulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Androgen receptor activity, organism-specific biosystem
      Regulation of Androgen receptor activity
    • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of retinoblastoma protein, organism-specific biosystem
      Regulation of retinoblastoma protein
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in paralell with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Stabilization of p53, organism-specific biosystem (from REACTOME)
      Stabilization of p53, organism-specific biosystemLater studies pin-pointed that a single serine (Ser-15) was phosphorylated by ATM and phosphorylation of Ser-15 was rapidly-induced in IR-treated cells and this response was ATM-dependent (Canman et ...
    • Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem
      Sumoylation by RanBP2 regulates transcriptional repression
    • Trafficking of AMPA receptors, organism-specific biosystem (from REACTOME)
      Trafficking of AMPA receptors, organism-specific biosystemRepetitive presynaptic activity causes long lasting changes in the postsynaptic transmission by changing the type and the number of AMPA receptors. These changes are brought about by trafficking mec...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
      Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
    • Tryptophan metabolism, organism-specific biosystem (from WikiPathways)
      Tryptophan metabolism, organism-specific biosystem
      Tryptophan metabolism
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
      p53 pathway, organism-specific biosystem
      p53 pathway
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53-Dependent G1 DNA Damage Response, organism-specific biosystem (from REACTOME)
      p53-Dependent G1 DNA Damage Response, organism-specific biosystemMost of the damage-induced modifications of p53 are dependent on the ATM kinase. The first link between ATM and p53 was predicted based on the earlier studies that showed that AT cells exhibit a redu...
    • p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystem (from REACTOME)
      p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystemThe arrest at G1/S checkpoint is mediated by the action of a widely known tumor suppressor protein, p53. Loss of p53 functions, as a result of mutations in cancer prevent the G1/S checkpoint (Kuerbi...

    Clone Names

    • MGC5370, MGC71221

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    p53 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ubiquitin-protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    		  
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
    Traceable Author Statement
    more info
    		  
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		  
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    establishment of protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nerve growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein destabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		  
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to antibiotic IEP
    Inferred from Expression Pattern
    more info
    		  
    synaptic transmission TAS
    Traceable Author Statement
    more info
    		  
    traversing start control point of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    insoluble fraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase Mdm2
    Names
    E3 ubiquitin-protein ligase Mdm2
    oncoprotein Mdm2
    MDM2 variant FB28
    MDM2 variant FB30
    double minute 2, human homolog of; p53-binding protein
    Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
    NP_002383.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016708.1 RefSeqGene

      Range
      5001..42242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002392.3 → NP_002383.2  E3 ubiquitin-protein ligase Mdm2 isoform MDM2

      Status: REVIEWED

      Source sequence(s)
      AA708958, AC025423, AK290341
      Consensus CDS
      CCDS8986.2
      UniProtKB/Swiss-Prot
      Q00987
      Related
      ENSP00000417281, OTTHUMP00000183488, ENST00000462284, OTTHUMT00000286419
      Conserved Domains (3) summary
      cl02489
      Location:46 – 106
      Blast Score: 179
      SWIB; SWIB/MDM2 domain
      cl02656
      Location:306 – 334
      Blast Score: 105
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl15348
      Location:442 – 489
      Blast Score: 132
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      69201971..69239212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      66252429..66289772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

     

    1. NM_001145336.1: Suppressed sequence

      Description
      NM_001145336.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_001145337.1: Suppressed sequence

      Description
      NM_001145337.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which is derived from a tumor cell line, compared to the reported wild-type transcript.

    3. NM_001145339.1: Suppressed sequence

      Description
      NM_001145339.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which is derived from a tumor cell line, compared to the reported wild-type transcript.

    4. NM_001145340.1: Suppressed sequence

      Description
      NM_001145340.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which lacks consecutive internal exons, compared to the reported wild-type transcript.

    5. NM_006878.3: Suppressed sequence

      Description
      NM_006878.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which lacks consecutive internal exons and contains non-consensus splice sites, compared to the reported wild-type transcript.

    6. NM_006879.3: Suppressed sequence

      Description
      NM_006879.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which lacks consecutive internal exons and contains non-consensus splice sites, compared to the reported wild-type transcript.

    7. NM_006880.2: Suppressed sequence

      Description
      NM_006880.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    8. NM_006881.3: Suppressed sequence

      Description
      NM_006881.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which lacks consecutive internal exons and contains non-consensus splice sites, compared to the reported wild-type transcript.

    9. NM_006882.3: Suppressed sequence

      Description
      NM_006882.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which lacks consecutive internal exons and contains non-consensus splice sites, compared to the reported wild-type transcript.

    10. NM_032739.1: Suppressed sequence

      Description
      NM_032739.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC025423.32 (104079..141286) None
    genomic AF527840.1 AAM78554.1
    genomic AJ251943.1 CAB64448.1
    genomic AJ517838.1 CAD57166.1
    genomic AJ517839.1 CAD57167.1
    genomic AJ517840.1 CAD57168.1
    genomic CH471054.1 EAW97201.1
      EAW97202.1
      EAW97203.1
      EAW97204.1
      EAW97205.1
      EAW97206.1
      EAW97207.1
      EAW97208.1
      EAW97209.1
      EAW97210.1
      EAW97211.1
      EAW97212.1
      EAW97213.1
      EAW97214.1
    genomic U28935.1 AAA82237.1
    genomic U39736.1 AAA82061.1
    mRNA AA708958.1 None
    mRNA AF092843.1 AAL40178.1
    mRNA AF092844.1 AAL40179.1
    mRNA AF092845.1 AAL40180.1
    mRNA AF201370.1 AAF42995.1
    mRNA AF201371.1 None
    mRNA AF385322.1 AAL13242.1
    mRNA AF385323.1 AAL13243.1
    mRNA AF385324.1 AAL13244.1
    mRNA AF385325.1 AAL13245.1
    mRNA AF385326.1 AAL13246.1
    mRNA AF385327.1 AAL13247.1
    mRNA AJ276888.1 None
    mRNA AJ278975.1 CAC07809.1
    mRNA AJ278976.1 CAC07810.1
    mRNA AJ278977.1 CAC07811.1
    mRNA AJ278978.1 CAC07812.1
    mRNA AJ430612.1 CAD23251.1
    mRNA AJ430613.1 None
    mRNA AJ430614.1 CAD23252.1
    mRNA AJ491698.1 CAD36959.1
    mRNA AJ491699.1 CAD36960.1
    mRNA AJ491700.1 CAD36961.1
    mRNA AJ491701.1 CAD36962.1
    mRNA AJ550516.1 CAD79455.1
    mRNA AJ550517.1 CAD79456.1
    mRNA AJ550518.1 CAD79457.1
    mRNA AJ550519.1 CAD79458.1
    mRNA AJ550520.1 CAD79459.1
    mRNA AK290341.1 BAF83030.1
    mRNA AK312105.1 BAG35041.1
    mRNA BC006795.1 None
    mRNA BC065505.1 None
    mRNA BC107414.1 None
    mRNA BC152384.1 AAI52385.1
    mRNA BC152390.1 AAI52391.1
    mRNA BE296905.1 None
    mRNA BF208689.1 None
    mRNA BT007258.1 AAP35922.1
    mRNA EU076746.1 ABT17083.1
    mRNA EU076747.1 ABT17084.1
    mRNA EU076748.1 ABT17085.1
    mRNA EU076749.1 ABT17086.1
    mRNA GQ848196.1 ACX31156.1
    mRNA HM213901.1 None
    mRNA HM213902.1 None
    mRNA HM213903.1 None
    mRNA HM213904.1 None
    mRNA M92424.1 AAA60568.1
    mRNA U33199.1 AAA75514.1
    mRNA U33200.1 AAA75515.1
    mRNA U33201.1 AAA75516.1
    mRNA U33202.1 AAA75517.1
    mRNA U33203.1 AAA75518.1
    mRNA Z12020.1 CAA78055.1
    other-genetic BC148522.1 AAI48523.1
    other-genetic BC153117.1 AAI53118.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q00987.1 GenPept UniProtKB/Swiss-Prot:Q00987
    Q546E6 GenPept UniProtKB/TrEMBL:Q546E6
    Q86WA2 GenPept UniProtKB/TrEMBL:Q86WA2
    Q86WA3 GenPept UniProtKB/TrEMBL:Q86WA3
    Q86WA4 GenPept UniProtKB/TrEMBL:Q86WA4
    Q86WA5 GenPept UniProtKB/TrEMBL:Q86WA5
    Q8NDV9 GenPept UniProtKB/TrEMBL:Q8NDV9
    Q8NDW0 GenPept UniProtKB/TrEMBL:Q8NDW0
    Q8NDW1 GenPept UniProtKB/TrEMBL:Q8NDW1
    Q8NDW2 GenPept UniProtKB/TrEMBL:Q8NDW2
    Q8TE46 GenPept UniProtKB/TrEMBL:Q8TE46
    Q8TE47 GenPept UniProtKB/TrEMBL:Q8TE47
    Q8WYJ3 GenPept UniProtKB/TrEMBL:Q8WYJ3
    Q96DS0 GenPept UniProtKB/TrEMBL:Q96DS0
    Q96DS1 GenPept UniProtKB/TrEMBL:Q96DS1
    Q96DS2 GenPept UniProtKB/TrEMBL:Q96DS2
    Q96DS3 GenPept UniProtKB/TrEMBL:Q96DS3
    Q96DS4 GenPept UniProtKB/TrEMBL:Q96DS4
    Q96DS5 GenPept UniProtKB/TrEMBL:Q96DS5
    Q9H4C2 GenPept UniProtKB/TrEMBL:Q9H4C2
    Q9H4C3 GenPept UniProtKB/TrEMBL:Q9H4C3
    Q9H4C4 GenPept UniProtKB/TrEMBL:Q9H4C4
    Q9H4C5 GenPept UniProtKB/TrEMBL:Q9H4C5
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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