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AdamTS-A ADAM metallopeptidase with thrombospondin type 1 motif A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41887, updated on 11-Apr-2024

Summary

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Official Symbol
AdamTS-Aprovided by FlyBase
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif Aprovided by FlyBase
Primary source
FLYBASE:FBgn0286071
Locus tag
Dmel_CG14869
See related
AllianceGenome:FB:FBgn0286071
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ADAMTS-A; CG14869; CG6107; CT19033; Dmel\CG14869; l(3)89Aa; rnwy
Summary
Predicted to enable metalloendopeptidase activity. Involved in several processes, including ameboidal-type cell migration; larval salivary gland morphogenesis; and pole cell migration. Predicted to be active in extracellular matrix. Is expressed in several structures, including embryonic/larval hemocyte; embryonic/larval midgut longitudinal visceral muscle cell; embryonic/larval salivary gland; glial cell of the perineurium; and longitudinal visceral muscle primordium. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to several human genes including ADAMTS20 (ADAM metallopeptidase with thrombospondin type 1 motif 20) and ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See AdamTS-A in Genome Data Viewer
Location:
88F5-88F6; 3-57 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15442246..15476193, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11267968..11301915, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Actin 88F Neighboring gene snoRNA:Orphan H/ACA box 9 Neighboring gene B9d1 Neighboring gene Rhodopsin 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Simulation and in vivo experimentation predict AdamTS-A location of function during caudal visceral mesoderm migration in Drosophila. Hamilton WC, et al. Dev Dyn, 2022 Jul. PMID 35023238
  2. Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization. Nicholson AC, et al. BMC Evol Biol, 2005 Feb 4. PMID 15693998, Free PMC Article
  3. Nucleoporin107 mediates female sexual differentiation via Dsx. Shore T, et al. Elife, 2022 Mar 21. PMID 35311642, Free PMC Article
  4. The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception. Nagy V, et al. Cell Cycle, 2015. PMID 25891934, Free PMC Article
  5. Sol narae (Sona) is a Drosophila ADAMTS involved in Wg signaling. Kim GW, et al. Sci Rep, 2016 Aug 18. PMID 27535473, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In this study, whole genome expression analysis was performed to identify genes activated by JAK/STAT and/or EGFR..AdamTS-A mRNA becomes enriched at the anterior and posterior poles of the egg chamber at stages 6 to 7 and is regulated by JAK/STAT.
    Title: A Gene Expression Screen in Drosophila melanogaster Identifies Novel JAK/STAT and EGFR Targets During Oogenesis.
  2. This work supports a model in which AdamTS-A anchors cells in place and preserves central nervous system architecture by reducing tissue stiffness.
    Title: The extracellular metalloprotease AdamTS-A anchors neural lineages in place within and preserves the architecture of the central nervous system.
  3. ADAMTS-A detaches salivary gland cells from the apical extracellular matrix.
    Title: The secreted AdamTS-A metalloprotease is required for collective cell migration.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
  
involved_in extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mesodermal cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADAM metallopeptidase with thrombospondin type 1 motif A
Names
AdamTS-A-PB
AdamTS-A-PC
AdamTS-A-PE
CG14869-PB
CG14869-PC
CG14869-PE
lethal (3) 89Aa
runaway
NP_001262604.1
NP_732036.2
NP_996218.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15442246..15476193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206496.2 → NP_996218.1  ADAM metallopeptidase with thrombospondin type 1 motif A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996218.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXB0, Q9VF61
    Conserved Domains (7) summary
    smart00209
    Location:754 → 806
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:455 → 655
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:457 → 655
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:286 → 394
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:937 → 1042
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08685
    Location:1495 → 1687
    GON; GON domain
    pfam12115
    Location:696 → 745
    Salp15; Salivary protein of 15kDa inhibits CD4+ T cell activation

  2. NM_001275675.1 → NP_001262604.1  ADAM metallopeptidase with thrombospondin type 1 motif A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262604.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHK4
    Conserved Domains (7) summary
    smart00209
    Location:651 → 703
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:352 → 552
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:354 → 552
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:183 → 291
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:834 → 939
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08685
    Location:1392 → 1584
    GON; GON domain
    pfam12115
    Location:593 → 642
    Salp15; Salivary protein of 15kDa inhibits CD4+ T cell activation

  3. NM_169659.3 → NP_732036.2  ADAM metallopeptidase with thrombospondin type 1 motif A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732036.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KSH7
    Related
    FBpp0308490
    Conserved Domains (7) summary
    smart00209
    Location:603 → 655
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:304 → 504
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:306 → 504
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:135 → 243
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:786 → 891
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08685
    Location:1344 → 1536
    GON; GON domain
    pfam12115
    Location:545 → 594
    Salp15; Salivary protein of 15kDa inhibits CD4+ T cell activation
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHK4 A0A0B4KHK4
Q7KSH7 Q7KSH7
Q8SXB0 Q8SXB0

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