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    MDFI MyoD family inhibitor [ Homo sapiens ]

    Gene ID: 4188, updated on 11-May-2012

    Summary

    Official Symbol
    MDFIprovided by HGNC
    Official Full Name
    MyoD family inhibitorprovided by HGNC
    Primary source
    HGNC:6967
    Locus tag
    RP4-696P19.1
    See related
    Ensembl:ENSG00000112559; HPRD:07280; MIM:604971; Vega:OTTHUMG00000014681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    I-MF; I-mfa
    Summary
    This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    6p21
    Sequence :
    Chromosome: 6; NC_000006.11 (41606195..41621982)
    See MDFI in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505730 Neighboring gene forkhead box P4 Neighboring gene microRNA 4641 Neighboring gene nucleophosmin (nucleolar phosphoprotein B23, numatrin) pseudogene Neighboring gene transcription factor EB

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q99750 Q9NRN7 AASDHPPT    HPRD  PubMed  
    Q99750 Q02040 AKAP17A    HPRD  PubMed  
    Q99750 O43299 AP5Z1    HPRD  PubMed  
    Q99750 P29972 AQP1    HPRD  PubMed  
    Q99750 P55064 AQP5    HPRD  PubMed  
    Q99750 O94817 ATG12    HPRD  PubMed  
    Q99750 P54259 ATN1    HPRD  PubMed  
    Q99750 Q5T6C5 ATXN7L2    HPRD  PubMed  
    Q99750 Q8WXS3 BAALC    HPRD  PubMed  
    Q99750 Bromo adjacent homology domain containing 1 BAHD1    HPRD  PubMed  
    Q99750 Q5T681 C10orf62    HPRD  PubMed  
    Q99750 Chromosome 12 open reading frame 12 C12orf12    HPRD  PubMed  
    Q99750 Q9H0I2 C16orf48    HPRD  PubMed  
    Q99750 C18orf56 protein C18orf56    HPRD  PubMed  
    Q99750 Q96EN9 C19orf60    HPRD  PubMed  
    Q99750 Q8N715 C1orf65    HPRD  PubMed  
    Q99750 Q8IYR0 C6orf165    HPRD  PubMed  
    Q99750 Hypothetical protein FLJ25402 C8orf48    HPRD  PubMed  
    Q99750 Q3YEC7 C9orf86    HPRD  PubMed  
    Q99750 CATSPER CATSPER1    HPRD  PubMed  
    Q99750 O43439 CBFA2T2    HPRD  PubMed  
    Q99750 Q14781 CBX2    HPRD  PubMed  
    Q99750 Q8IYX3 CCDC116    HPRD  PubMed  
    Q99750 Q96HB5 CCDC120    HPRD  PubMed  
    Q99750 Q9UKJ5 CHIC2    HPRD  PubMed  
    Q99750 Cyclin M3 CNNM3    HPRD  PubMed  
    Q99750 Q5TA45 CPSF3L    HPRD  PubMed  
    Q99750 O43186 CRX    HPRD  PubMed  
    Q99750 Q16526 CRY1    HPRD  PubMed  
    Q99750 WD repeat domain 42A DCAF8    HPRD  PubMed  
    Q99750 Q9NUU7 DDX19A    HPRD  PubMed  
    Q99750 Q96LJ7 DHRS1    HPRD  PubMed  
    Q99750 O94907 DKK1    HPRD  PubMed  
    Q99750 Q9ULA0 DNPEP    HPRD  PubMed  
    Q99750 Q16828 DUSP6    HPRD  PubMed  
    Q99750 Q14213 EBI3    HPRD  PubMed  
    Q99750 Q01844 EWSR1    HPRD  PubMed  
    Q99750 Q9H5Z6 FAM124B    HPRD  PubMed  
    Q99750 Q14296 FASTK    HPRD  PubMed  
    Q99750 Q969U6 FBXW5    HPRD  PubMed  
    Q99750 O00144 FZD9    HPRD  PubMed  
    Q99750 P04899 GNAI2    HPRD  PubMed  
    Q99750 O60269 GPRIN2    HPRD  PubMed  
    Q99750 P49639 HOXA1    HPRD  PubMed  
    Q99750 P17482 HOXB9    HPRD  PubMed  
    Q99750 Q12906 ILF3    HPRD  PubMed  
    Q99750 Q8NA54 IQUB    HPRD  PubMed  
    Q99750 Q6ZU52 KIAA0408    HPRD  PubMed  
    Q99750 Q14847 LASP1    HPRD  PubMed  
    Q99750 Q8TAP4 LMO3    HPRD  PubMed  
    Q99750 O75427 LRCH4    HPRD  PubMed  
    Q99750 Q8WUT4 LRRN4    HPRD  PubMed  
    Q99750 P33992 MCM5    HPRD  PubMed  
    Q99750 Q99750 MDFI    HPRD  PubMed  
    Q99750 FLJ20859 protein METTL17    HPRD  PubMed  
    Q99750 Q96ES6 MFSD3    HPRD  PubMed  
    Q99750 P13349 MYF5    HPRD  PubMed  
    Q99750 P15173 MYOG    HPRD  PubMed  
    Q99750 Q9NQX5 NPDC1    HPRD  PubMed  
    Q99750 P55055 NR1H2    HPRD  PubMed  
    Q99750 P32242 OTX1    HPRD  PubMed  
    Q99750 O95336 PGLS    HPRD  PubMed  
    Q99750 Q8WV24 PHLDA1    HPRD  PubMed  
    Q99750 Q9HB75 PIDD    HPRD  PubMed  
    Q99750 Q13526 PIN1    HPRD  PubMed  
    Q99750 Q92692 PVRL2    HPRD  PubMed  
    Q99750 P48378 RFX2    HPRD  PubMed  
    Q99750 P84101 SERF2    HPRD  PubMed  
    Q99750 O60289 SFI1    HPRD  PubMed  
    Q99750 Q15475 SIX1    HPRD  PubMed  
    Q99750 P78381 SLC35A2    HPRD  PubMed  
    Q99750 P19634 SLC9A1    HPRD  PubMed  
    Q99750 Q9UQ90 SPG7    HPRD  PubMed  
    Q99750 Q03518 TAP1    HPRD  PubMed  
    Q99750 P15923 TCF3    HPRD  PubMed  
    Q99750 Q9BT49 THAP7    HPRD  PubMed  
    Q99750 Theg homolog THEG    HPRD  PubMed  
    Q99750 Q9GZM7 TINAGL1    HPRD  PubMed  
    Q99750 C18orf45 protein TMEM241    HPRD  PubMed  
    Q99750 O43734 TRAF3IP2    HPRD  PubMed  
    Q99750 P48995 TRPC1    HPRD  PubMed  
    Q99750 Q9H1D0 TRPV6    HPRD  PubMed  
    Q99750 Q15906 VPS72    HPRD  PubMed  
    Q99750 Q96HA8 WDYHV1    HPRD  PubMed  
    Q99750 O43167 ZBTB24    HPRD  PubMed  
    Q99750 P24278 ZBTB25    HPRD  PubMed  
    Q99750 Q8IZC7 ZNF101    HPRD  PubMed  
    Q99750 P52737 ZNF136    HPRD  PubMed  
    Q99750 O95201 ZNF205    HPRD  PubMed  
    Q99750 Q9H9D4 ZNF408    HPRD  PubMed  
    Q99750 Q8TAU3 ZNF417    HPRD  PubMed  
    Q99750 Q9BUY5 ZNF426    HPRD  PubMed  
    Q99750 Q8NDP4 ZNF439    HPRD  PubMed  
    Q99750 Q8IYI8 ZNF440    HPRD  PubMed  
    Q99750 Q9BR84 ZNF559    HPRD  PubMed  
    Q99750 Q9P0T4 ZNF581    HPRD  PubMed  
    Q99750 Q96SK3 ZNF607    HPRD  PubMed  
    Q99750 O15015 ZNF646    HPRD  PubMed  
    Q99750 Q8IYX0 ZNF679    HPRD  PubMed  
    Q99750 Q96C28 ZNF707    HPRD  PubMed  
    Q99750 Q96H86 ZNF764    HPRD  PubMed  
    Q99750 Hypothetical protein MGC21881     HPRD  PubMed  
    Q99750 MGC42630     HPRD  PubMed  
    BioGRID:110353 BioGRID:121927 AASDHPPT    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:113860 AKAP17A    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:115236 AP5Z1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:106854 AQP1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:106858 AQP5    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:114587 ATG12    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:122958 BAALC    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:116558 BAHD1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:135946 C10orf62    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:128212 C12orf12    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:123875 C16orf48    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:138970 C18orf56    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:120372 C19orf60    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:127889 C1orf65    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:127543 C6orf165    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:127623 C8orf48    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:120812 C9orf86    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110353 BioGRID:125556 CATSPER1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:114586 CBFA2T2    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:124228 CBX2    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:127896 CCDC116    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:124658 CCDC120    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:117716 CHIC2    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:117712 CNNM3    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:120310 CPSF3L    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:107796 CRX    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:107797 CRY1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:119121 DCAF8    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:120592 DDX19A    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:125457 DHRS1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:116599 DKK1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:117093 DNPEP    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:108181 DUSP6    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:115450 EBI3    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:108431 EWSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:122934 FAM124B    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:130349 FAM27E3    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:116126 FASTK    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:119967 FBXW5    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:113922 FZD9    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:109033 GNAI2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110353 BioGRID:115070 GPRIN2    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:109438 HOXA1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:109459 HOXB9    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:109822 ILF3    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:127562 IQUB    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110353 BioGRID:115078 KIAA0408    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:110120 LASP1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:120977 LMO3    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:110214 LRCH4    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:127893 LRRN4    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:110342 MCM5    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:110353 MDFI    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:122261 METTL17    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:125254 MFSD3    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:133248 MGC21881    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:110702 MYF5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110353 BioGRID:110737 MYOD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110353 BioGRID:110739 MYOG    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110353 BioGRID:121167 NPDC1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:113222 NR1H2    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:111053 OTX1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:117328 PGLS    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110353 BioGRID:116498 PHLDA1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:120645 PIDD    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:111317 PIN1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:111777 PVRL2    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:111922 RFX2    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:115471 SERF2    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:115153 SFI1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:112386 SIX1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110353 BioGRID:113202 SLC35A2    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:112438 SLC9A1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:112565 SPG7    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:112753 TAP1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:123298 THAP7    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:119449 THEG    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:122078 TINAGL1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:124432 TMEM241    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:115979 TRAF3IP2    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:120683 TRPV6    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:113164 UBC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110353 BioGRID:112804 VPS72    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:120405 WDYHV1    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:115177 ZBTB24    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:113422 ZBTB25    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110353 BioGRID:125102 ZNF101    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:113490 ZNF136    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:113539 ZNF205    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:122894 ZNF408    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:127075 ZNF417    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:122536 ZNF426    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:124741 ZNF439    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:125953 ZNF440    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:124118 ZNF559    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:119601 ZNF581    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:124252 ZNF607    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:115075 ZNF646    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:127961 ZNF679    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:130290 ZNF707    BioGRID  PubMed Two-hybrid 
    BioGRID:110353 BioGRID:124959 ZNF764    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    activation of JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic sequestering of transcription factor TAS
    Traceable Author Statement
    more info
    PubMed 
    dorsal/ventral axis specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    embryo development TAS
    Traceable Author Statement
    more info
    PubMed 
    embryonic skeletal system morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of Wnt receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    trophoblast giant cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    myoD family inhibitor
    Names
    myoD family inhibitor
    myogenic repressor I-mf
    inhibitor of MyoD family a

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005586.3NP_005577.1  myoD family inhibitor

      Status: REVIEWED

      Source sequence(s)
      BC007836, BG818571, CA393148
      Consensus CDS
      CCDS4857.1
      UniProtKB/Swiss-Prot
      Q99750
      Related
      ENSP00000230321, OTTHUMP00000016375, ENST00000230321, OTTHUMT00000040518

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      41606195..41621982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      41324752..41340811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL035588.21 CAB54148.1
      CAD92607.1
      CAI22456.1
      CAO72132.1
      CAO72133.1
      CAO72134.1
      CAO72135.1
    genomic CH471081.1 EAX04051.1
      EAX04052.1
      EAX04053.1
    mRNA AK290735.1 BAF83424.1
    mRNA BC007836.2 AAH07836.1
    mRNA BG818571.1 None
    mRNA CA393148.1 None
    mRNA U78313.1 AAB39748.1
    other-genetic JF432465.1 ADZ15682.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99750.1 GenPept UniProtKB/Swiss-Prot:Q99750

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