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MDFI MyoD family inhibitor [ Homo sapiens (human) ]

Gene ID: 4188, updated on 12-Apr-2014
Official Symbol
MDFIprovided by HGNC
Official Full Name
MyoD family inhibitorprovided by HGNC
Primary source
HGNC:6967
Locus tag
RP4-696P19.1
See related
Ensembl:ENSG00000112559; HPRD:07280; MIM:604971; Vega:OTTHUMG00000014681
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
I-MF; I-mfa
Summary
This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008]
Location :
6p21
Sequence :
Chromosome: 6; NC_000006.12 (41638456..41654246)
See MDFI in Epigenomics, MapViewer

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101060264 Neighboring gene forkhead box P4 Neighboring gene microRNA 4641 Neighboring gene nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 51 Neighboring gene transcription factor EB

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat HIV-1 Tat 47-59 peptide downregulates gene expression of MyoD family inhibitor (MDFI) in U-937 macrophages PubMed
tat The cysteine-rich region (residues 21-37) of Tat is essential for direct interaction with HIC or I-MFA PubMed
tat I-mfa (inhibitor of MyoD family a) and HIC (human I-mfa-domain-containing) proteins serve as substrates for P-TEFb. Their I-mfa domains bind the activation domain of HIV-1 Tat and inhibit Tat- and P-TEFb-dependent HIV-1 transcription PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic sequestering of transcription factor TAS
Traceable Author Statement
more info
PubMed 
dorsal/ventral axis specification ISS
Inferred from Sequence or Structural Similarity
more info
 
embryo development TAS
Traceable Author Statement
more info
PubMed 
embryonic skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
trophoblast giant cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
myoD family inhibitor
Names
myoD family inhibitor
myogenic repressor I-mf
inhibitor of MyoD family a

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005586.3NP_005577.1  myoD family inhibitor

    See proteins identical to NP_005577.1

    Status: REVIEWED

    Source sequence(s)
    BC007836, BG818571, CA393148
    Consensus CDS
    CCDS4857.1
    UniProtKB/Swiss-Prot
    Q99750
    Related
    ENSP00000230321, OTTHUMP00000016375, ENST00000230321, OTTHUMT00000040518
    Conserved Domains (1) summary
    pfam15316
    Location:80246
    Blast Score: 407
    MDFI; MyoD family inhibitor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12

    Range
    41638456..41654246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249117.1XP_005249174.1  

    Conserved Domains (1) summary
    pfam15316
    Location:63229
    Blast Score: 405
    MDFI; MyoD family inhibitor
  2. XM_005249119.1XP_005249176.1  

    UniProtKB/TrEMBL
    B1AKB6
    Conserved Domains (1) summary
    pfam15316
    Location:9185
    Blast Score: 371
    MDFI; MyoD family inhibitor
  3. XM_005249120.1XP_005249177.1  

  4. XM_005249118.2XP_005249175.1  

    Conserved Domains (1) summary
    pfam15316
    Location:20186
    Blast Score: 378
    MDFI; MyoD family inhibitor

Alternate HuRef

Genomic

  1. AC_000138.1 Alternate HuRef

    Range
    41324752..41340811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    41609581..41625365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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