CycC Cyclin C [Drosophila melanogaster] - Gene

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Summary

Official Symbol: CycCprovided by Flybase
Official Full Name: Cyclin Cprovided by Flybase
Primary source: FLYBASE:FBgn0004597
Locus tag: Dmel_CG7281
Gene type: protein coding
RNA name: cyclin C
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1C_DROME; CG7281; Cln3; Cyc-C; cycC; cyclinC; DmcycC; Dmel\CG7281; dTRAP33; SRB11

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Genomic context

Location :: 88D6-88D6

Sequence :: Chromosome: 3R; NT_033777.2 (10714726..10715915, complement)

See CycC in Epigenomics, MapViewer

Chromosome 3R - NT_033777.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:66871	BioGRID:67008	Akt1	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:59096	CG12985	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:64968	CG13458	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:62958	CG13871	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:66425	CG14684	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:59727	CG17265	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:66980	CG4546	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:61084	CG5783	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:58798	CG9072	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:62567	Cdk4	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:62461	Cdk5	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:64544	Cdk8	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:66871	BioGRID:66209	Cks85A	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:58898	CycD	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:68567	CycG	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:65669	CycH	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:67322	Dys	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:63926	Eip63E	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:60705	Elf	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:68794	Pak	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:61322	RPA2	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:65629	SAK	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:60495	cdc2	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:67428	cdc2c	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:61832	dap	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:72797	katanin-60	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:64781	l(3)S147910	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:68973	pie	BioGRID	PubMed	Two-hybrid
BioGRID:66871	BioGRID:69325	plu	BioGRID	PubMed	Two-hybrid

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General gene information

Markers

Dm1832 (e-PCR)
- UniSTS:74068

Homology

Homologs of the CycC gene: The CycC gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, and A.thaliana.

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
RNA polymerase II transcription cofactor activity	IMP Inferred from Mutant Phenotype more info	PubMed
RNA polymerase II transcription cofactor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
cyclin-dependent protein kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
cyclin-dependent protein kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
cyclin-dependent protein kinase regulator activity	NAS Non-traceable Author Statement more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info
chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
imaginal disc-derived leg segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
mitotic cell cycle G2/M transition DNA damage checkpoint	IGI Inferred from Genetic Interaction more info
regulation of cyclin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
sex comb development	IMP Inferred from Mutant Phenotype more info	PubMed
transcription initiation from RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
DNA-directed RNA polymerase II, holoenzyme	IEA Inferred from Electronic Annotation more info
mediator complex	IPI Inferred from Physical Interaction more info	PubMed
mediator complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
nuclear cyclin-dependent protein kinase holoenzyme complex	NAS Non-traceable Author Statement more info

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General protein information

Preferred Names: CG7281 gene product from transcript CG7281-RA

Names: CG7281-PA; CycC-PA; cyclin C

NP_476848.1

EC 2.7.1.-

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.2

Range

10714726..10715915, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057500.3 → NP_476848.1 cyclin C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P25008

Related

FBpp0082469, FBtr0083010

Conserved Domains (3) summary

cd00043
Location:48 – 99
Blast Score: 107

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

COG5333
Location:1 – 228
Blast Score: 328

CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

cl00050
Location:171 – 237
Blast Score: 95

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...