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    MCM6 minichromosome maintenance complex component 6 [ Homo sapiens ]

    Gene ID: 4175, updated on 19-May-2012
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    Summary

    Official Symbol
    MCM6provided by HGNC
    Official Full Name
    minichromosome maintenance complex component 6provided by HGNC
    Primary source
    HGNC:6949
    See related
    Ensembl:ENSG00000076003; HPRD:03485; MIM:601806; Vega:OTTHUMG00000131739
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Mis5; P105MCM; MCG40308
    Summary
    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]
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    Genomic context

    Location :
    2q21
    Sequence :
    Chromosome: 2; NC_000002.11 (136597196..136634011, complement)
    See MCM6 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene UBX domain protein 4 Neighboring gene uncharacterized LOC100507600 Neighboring gene lactase Neighboring gene mannosidase, endo-alpha-like pseudogene Neighboring gene aspartyl-tRNA synthetase Neighboring gene uncharacterized LOC100131316

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Structural insights into the Cdt1-mediated MCM2-7 chromatin loading. Liu C, et al. Nucleic Acids Res, 2012 Apr. PMID 22140117.
    2. Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism. Fedorova OA, et al. Biochem Biophys Res Commun, 2011 Dec 16. PMID 22079093.
    3. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.

    See all (76) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Results indicate that the interaction between hCdt1 and hMcm6 through their interacting domains is key for hCdt1 in facilitating the MCM hetero-hexamer to load onto chromatin for replication licensing.
      Title: The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells.
    2. Meta-analysis of gene-disease association. (HuGE Navigator)
      Title: Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
    3. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Can lactase persistence genotype be used to reassess the relationship between renal cell carcinoma and milk drinking? Potentials and problems in the application of Mendelian randomization.
    4. The subtype and MCM6 protein expression in craniopharyngiomas are related to the prognosis of tumor.
      Title: [Expression of minichromosome maintenance protein 6 in craniopharyngioma and its correlation with prognosis].
    5. the molecular mechanism of Mcm2-7 chromatin loading and prereplicative complex assembly.
      Title: Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6.
    6. The numbers of the three genotypic combinations reveal that the percentage of this population that is genetically lactose intolerant is 8.23% and that the allele frequencies found are consistent with the expected Mendelian distribution.
      Title: The prevalence of lactose intolerance (adult hypolactasia) in a randomly selected New Zealand population.
    7. Data show that cells subjected to chronic hypoxia the replicative restart was inhibited along with numerous replication factors including MCM6 and RPA, and cells reoxygenated after acute hypoxia underwent rapid p53-dependent apoptosis.
      Title: Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
    9. Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
      Title: The T/G 13915 variant upstream of the lactase gene (LCT) is the founder allele of lactase persistence in an urban Saudi population.
    10. It was found that the MCM6 label index (LI) was significantly higher in adamantine epithelioma than squamous papillary tumor, and in both primary tumor subtypes the LIs of tumors with recurrence were higher than those without recurrence.
      Title: Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor.
    Submit: New GeneRIF Correction
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Lactase persistance/nonpersistance

    Tall stature, susceptibility to

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005906.2 NP_004517.2 MCM2    BIND  PubMed Mcm2 interacts with Mcm6. 
    NP_005906.2 NP_004517.2 MCM2    BIND  PubMed MCM2 interacts with MCM6. 
    NP_005906.2 NP_005905.2 MCM4    BIND  PubMed Mcm4 interacts with Mcm6. 
    NP_005906.2 NP_877423.1 MCM4    BIND  PubMed MCM4 interacts with MCM6. 
    NP_005906.2 NP_005906.2 MCM6    BIND  PubMed Mcm6 interacts with itself. 
    Q14566 Q53TS8 ALS2CR11    HPRD  PubMed  
    Q14566 P78396 CCNA1    HPRD  PubMed  
    Q14566 Q9H211 CDT1    HPRD  PubMed  
    Q14566 Q9UJA2 CRLS1    HPRD  PubMed  
    Q14566 O75496 GMNN    HPRD  PubMed  
    Q14566 Q9UBH0 IL36RN    HPRD  PubMed  
    Q14566 Q8WYH8 ING5    HPRD  PubMed  
    Q14566 Q7L590 MCM10    HPRD  PubMed  
    Q14566 P49736 MCM2    HPRD  PubMed  
    Q14566 P25205 MCM3    HPRD  PubMed  
    Q14566 P33991 MCM4    HPRD  PubMed  
    Q14566 Q14566 MCM6    HPRD  PubMed  
    Q14566 P33993 MCM7    HPRD  PubMed  
    Q14566 Q9UJA3 MCM8    HPRD  PubMed  
    Q14566 P42568 MLLT3    HPRD  PubMed  
    Q14566 Q13416 ORC2    HPRD  PubMed  
    Q14566 Q9Y5N6 ORC6    HPRD  PubMed  
    Q14566 P25786 PSMA1    HPRD  PubMed  
    Q14566 Q9BWG6 SCNM1    HPRD  PubMed  
    Q14566 Q14683 SMC1A    HPRD  PubMed  
    BioGRID:110343 BioGRID:106823 AIRE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110343 BioGRID:127358 ALS2CR11    BioGRID  PubMed Two-hybrid 
    BioGRID:110343 BioGRID:120845 ASF1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110343 BioGRID:113915 CDC45    BioGRID  PubMed Two-hybrid 
    BioGRID:110343 BioGRID:107463 CDKN2A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110343 BioGRID:123555 CDT1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure 
    BioGRID:110343 BioGRID:108325 EMD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110343 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110343 BioGRID:113955 HIST1H4A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110343 BioGRID:117728 IL36RN    BioGRID  PubMed Two-hybrid 
    BioGRID:110343 BioGRID:124016 ING5    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110343 BioGRID:117486 L3MBTL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110343 BioGRID:120654 MCM10    BioGRID  PubMed Two-hybrid 
    BioGRID:110343 BioGRID:110339 MCM2    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:110343 BioGRID:110341 MCM4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110343 BioGRID:110342 MCM5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110343 BioGRID:110343 MCM6    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110343 BioGRID:110344 MCM7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110343 BioGRID:124109 MCM8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110343 BioGRID:110446 MLLT3    BioGRID  PubMed Two-hybrid 
    BioGRID:110343 BioGRID:128982 MMS22L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110343 BioGRID:111040 ORC1    BioGRID  PubMed Two-hybrid 
    BioGRID:110343 BioGRID:111041 ORC2    BioGRID  PubMed Two-hybrid 
    BioGRID:110343 BioGRID:111042 ORC4    BioGRID  PubMed Two-hybrid 
    BioGRID:110343 BioGRID:111391 PMS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110343 BioGRID:111655 PSMA1    BioGRID  PubMed Two-hybrid 
    BioGRID:110343 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110343 BioGRID:112037 RPA1    BioGRID  PubMed Two-hybrid 
    BioGRID:110343 BioGRID:122476 SCNM1    BioGRID  PubMed Two-hybrid 
    BioGRID:110343 BioGRID:117071 SRRM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110343 BioGRID:112627 SSRP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110343 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110343 BioGRID:112744 TAF10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110343 BioGRID:112983 TNFAIP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110343 BioGRID:110863 TONSL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110343 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110343 BioGRID:117382 USP49    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110343 BioGRID:113622 USP7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110343 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the MCM6 gene: The MCM6 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Activation of ATR in response to replication stress, organism-specific biosystem (from REACTOME)
      Activation of ATR in response to replication stress, organism-specific biosystemGenotoxic stress caused by DNA damage or stalled replication forks can lead to genomic instability. To guard against such instability, genotoxically-stressed cells activate checkpoint factors that ha...
    • Activation of the pre-replicative complex, organism-specific biosystem (from REACTOME)
      Activation of the pre-replicative complex, organism-specific biosystemIn S. cerevisiae, two ORC subunits, Orc1 and Orc5, both bind ATP, and Orc1 in addition has ATPase activity. Both ATP binding and ATP hydrolysis appear to be essential functions in vivo. ATP binding b...
    • Assembly of the pre-replicative complex, organism-specific biosystem (from REACTOME)
      Assembly of the pre-replicative complex, organism-specific biosystemDNA replication pre-initiation in eukaryotic cells begins with the formation of the pre-replicative complex (pre-RC) during the late M phase and continues in the G1 phase of the mitotic cell cycle, a...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • DNA Replication, organism-specific biosystem (from WikiPathways)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • DNA Replication Pre-Initiation, organism-specific biosystem (from REACTOME)
      DNA Replication Pre-Initiation, organism-specific biosystemAlthough, DNA replication occurs in the S phase of the cell cycle, the formation of the DNA replication pre-initiation complex begins during G1 phase.
    • DNA replication, organism-specific biosystem (from KEGG)
      DNA replication, organism-specific biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
    • DNA replication, conserved biosystem (from KEGG)
      DNA replication, conserved biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
    • DNA strand elongation, organism-specific biosystem (from REACTOME)
      DNA strand elongation, organism-specific biosystemAccurate and efficient genome duplication requires coordinated processes to replicate two template strands at eucaryotic replication forks. Knowledge of the fundamental reactions involved in replicat...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
    • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
      G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
    • M/G1 Transition, organism-specific biosystem (from REACTOME)
      M/G1 Transition, organism-specific biosystemFinally, progression out of mitosis and division of the cell into two daughters (cytokinesis) requires the inactivation of Cyclin B - Cdc2 by ubiquitin-dependent proteolysis of Cyclin A and B, which ...
    • MCM complex, organism-specific biosystem (from KEGG)
      MCM complex, organism-specific biosystemStructural complex; Genetic information processing; Replication system
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Mitotic M-M/G1 phases, organism-specific biosystem (from REACTOME)
      Mitotic M-M/G1 phases, organism-specific biosystem
      Mitotic M-M/G1 phases
    • Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
      Orc1 removal from chromatin, organism-specific biosystem
      Orc1 removal from chromatin
    • Regulation of DNA replication, organism-specific biosystem (from REACTOME)
      Regulation of DNA replication, organism-specific biosystemDNA replication is regulated at various levels via ORC proteins. This pathway includes annotation of individual events that lead to the regulation of replication.
    • Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
      Removal of licensing factors from origins, organism-specific biosystemLicensing factors are removed from the origin by various means like biochemical modification (phosphorylation) or by physical association with other proteins. This pathway includes the annotations of...
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continu...
    • Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
      Switching of origins to a post-replicative state, organism-specific biosystem
      Switching of origins to a post-replicative state
    • Synthesis of DNA, organism-specific biosystem (from REACTOME)
      Synthesis of DNA, organism-specific biosystemThe actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of ...
    • Unwinding of DNA, organism-specific biosystem (from REACTOME)
      Unwinding of DNA, organism-specific biosystemDNA Replication is regulated accurately and precisely by various protein complexes. Many members of the MCM protein family are assembled into the pre-Replication Complexes (pre-RC) at the end of M ph...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    contributes_to ATP-dependent DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    DNA replication TAS
    Traceable Author Statement
    more info
    		  
    DNA strand elongation involved in DNA replication TAS
    Traceable Author Statement
    more info
    		  
    DNA unwinding involved in replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA-dependent DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    M/G1 transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    MCM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    DNA replication licensing factor MCM6
    Names
    DNA replication licensing factor MCM6
    minichromosome maintenance deficient (mis5, S. pombe) 6
    MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
    NP_005906.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008958.1 RefSeqGene

      Range
      4965..41816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005915.5 → NP_005906.2  DNA replication licensing factor MCM6

      Status: REVIEWED

      Source sequence(s)
      AA577398, BC020268, BC032374, CN389677, DA521248
      Consensus CDS
      CCDS2179.1
      UniProtKB/Swiss-Prot
      Q14566
      Related
      ENSP00000264156, OTTHUMP00000162532, ENST00000264156, OTTHUMT00000254658
      Conserved Domains (2) summary
      smart00350
      Location:119 – 657
      Blast Score: 1760
      MCM; minichromosome maintenance proteins
      cl09099
      Location:447 – 534
      Blast Score: 105
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      136597196..136634011, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      128590433..128627205, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC011893.7 AAX88925.1
    genomic AC011999.9 AAY15028.1
    genomic AY220757.1 AAO26043.1
    genomic CH471058.2 EAX11621.1
    genomic CS566136.1 CAN37618.1
    mRNA AA577398.1 None
    mRNA AK299236.1 BAG61268.1
    mRNA AK303455.1 BAG64499.1
    mRNA AK312575.1 BAG35469.1
    mRNA AU124893.1 None
    mRNA BC008774.1 None
    mRNA BC020268.1 None
    mRNA BC032374.1 AAH32374.1
    mRNA CN389677.1 None
    mRNA D84557.1 BAA12699.1
    mRNA DA521248.1 None
    mRNA U46838.1 AAC50766.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14566.1 GenPept UniProtKB/Swiss-Prot:Q14566
    Q4ZG57 GenPept UniProtKB/TrEMBL:Q4ZG57
    Q53T61 GenPept UniProtKB/TrEMBL:Q53T61
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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      General information

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