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    rdx roadkill [ Drosophila melanogaster ]

    Gene ID: 41704, updated on 10-May-2012
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    Summary

    Official Symbol
    rdxprovided by Flybase
    Official Full Name
    roadkillprovided by Flybase
    Primary source
    FLYBASE:FBgn0262907
    Locus tag
    Dmel_CG12537
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.577; BEST:GM07940; CG10235; CG12537; CG9924; D-SPOP; Dmel\CG12537; Dromel_CG9924_FBtr0082871_rdx_mORF; hib; HIB; l(3)03477; l(3)2004; l(3)88Aa; l(3)A6; l(3)dsl-6; l(3)dsl6; l(3)j1D1; l(3)j4C7; l(3)SG40; mei-P19; Rdx; Spop
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    Genomic context

    Location :
    88A3-88A5; 3-50.3 cM
    Sequence :
    Chromosome: 3R; NT_033777.2 (9793674..9857777, complement)
    See rdx in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene CG9925 gene product from transcript CG9925-RA Neighboring gene Origin recognition complex subunit 2 Neighboring gene ncRNA Neighboring gene CG3050 gene product from transcript CG3050-RA Neighboring gene CG3061 gene product from transcript CG3061-RA Neighboring gene CG9922 gene product from transcript CG9922-RA Neighboring gene transfer RNA:ser2b:88A

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal. Seong KH, et al. PLoS One, 2010 Dec 15. PMID 21179535.
    2. Drosophila Cand1 regulates Cullin3-dependent E3 ligases by affecting the neddylation of Cullin3 and by controlling the stability of Cullin3 and adaptor protein. Kim SH, et al. Dev Biol, 2010 Oct 15. PMID 20691177.
    3. Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. Gan Q, et al. Cell Res, 2010 Jul. PMID 20440302.
    4. Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila. González J, et al. PLoS Genet, 2010 Apr 8. PMID 20386746.
    5. Regulation of Hh signal transduction as Drosophila eye differentiation progresses. Baker NE, et al. Dev Biol, 2009 Nov 15. PMID 19761763.

    See all (35) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. two different mechanisms by which Rdx negatively regulates Ci may play an important role in the fine-tuning of Hh responses
      Title: Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal.
    2. a new role for SPOP (rdx) was identified; gene encoding SPOP is a target of segmentation transcription factors; SPOP mediates degradation of Puckered, thereby inducing tumor necrosis factor (TNF)/Eiger-dependent apoptosis
      Title: Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:66781 BioGRID:58547 ATP7    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:61153 CG10650    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:57550 CG12470    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:68044 CG14546    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:66523 CG14711    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:66369 CG16904    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:57754 CG2865    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:73158 CG30417    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:66556 CG31368    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:58683 CG32635    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:59654 CG3557    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:67577 CG5380    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:60518 CG6206    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:67643 CG6985    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:65631 CG7611    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:60251 CG8360    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:62031 CG9005    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:63706 CG9173    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:1455262 CR18854    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:58687 Cpr12A    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:60913 Cul-3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:66781 BioGRID:64332 ERR    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:64435 Galk    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:57583 Hmt4-20    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:71956 Mbs    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:67742 RanBP3    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:63429 Rap2l    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:57590 RpL22    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:67703 RpS3    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:66475 Tctp    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:68345 alph    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:68605 ci    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:66781 BioGRID:68504 cindr    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:57745 crn    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:57548 ewg    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:62523 krimp    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:58968 mbt    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:63592 mri    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:69974 nec    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:66141 puc    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:58848 sog    BioGRID  PubMed Two-hybrid 
    BioGRID:66781 BioGRID:69994 spir    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the rdx gene: The rdx gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, A.thaliana, and rice.

    Pathways from BioSystems

    • Cul3-SPOP complex, organism-specific biosystem (from KEGG)
      Cul3-SPOP complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' pol...

    mobile_element

    • Loc: c9849185-9847424 mobile_element_type = transposon:S{}rdx[S1357]
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    General protein information

    Preferred Names
    CG12537 gene product from transcript CG12537-RB
    Names
    CG12537-PA
    CG12537-PB
    CG12537-PC
    CG12537-PD
    CG12537-PE
    Hh-induced MATH and BTB domain containing protein
    hedegehog-induced BTB protein
    hedgehog- induced BTB protein
    meiotic P19
    rdx-PA
    rdx-PB
    rdx-PC
    rdx-PD
    rdx-PE
    roadkill
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      9793674..9857777, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169566.1 → NP_731877.1  roadkill, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VFP2
      Related
      FBpp0290847, FBtr0301633
      Conserved Domains (2) summary
      cd03774
      Location:28 – 166
      Blast Score: 667
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cl02518
      Location:190 – 294
      Blast Score: 230
      BTB; BTB/POZ domain

    2. NM_169564.1 → NP_731875.1  roadkill, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VFP2
      Related
      FBpp0100174, FBtr0100852
      Conserved Domains (2) summary
      cd03774
      Location:57 – 195
      Blast Score: 671
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cl02518
      Location:219 – 323
      Blast Score: 231
      BTB; BTB/POZ domain

    3. NM_142068.1 → NP_650325.1  roadkill, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VFP2
      Related
      FBpp0290848, FBtr0301634
      Conserved Domains (2) summary
      cd03774
      Location:57 – 195
      Blast Score: 671
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cl02518
      Location:219 – 323
      Blast Score: 231
      BTB; BTB/POZ domain

    4. NM_142069.3 → NP_650326.3  roadkill, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VFP2
      Related
      FBpp0099767, FBtr0100361
      Conserved Domains (2) summary
      cd03774
      Location:483 – 621
      Blast Score: 675
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cl02518
      Location:645 – 749
      Blast Score: 234
      BTB; BTB/POZ domain

    5. NM_169565.1 → NP_731876.2  roadkill, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAF6
      UniProtKB/Swiss-Prot
      Q9VFP2
      Related
      FBpp0290846, FBtr0301632
      Conserved Domains (2) summary
      cd03774
      Location:60 – 198
      Blast Score: 670
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cl02518
      Location:222 – 326
      Blast Score: 231
      BTB; BTB/POZ domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014297.2 AAN14348.1
    mRNA AY121682.1 AAM52009.1
    mRNA BT012443.1 AAS93714.1
    genomic AE014297.2 AAN14346.1
    genomic AE014297.2 AAN14347.1
    mRNA BT021321.1 AAX33469.1
    genomic AE014297.2 AAF55008.2
    mRNA BT099706.1 ACV53070.1
    genomic AE014297.2 AAF55007.3
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAF55007.2 GenPept
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    Additional Links

    Gene LinkOut

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