ems empty spiracles [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: emsprovided by FlyBase
Official Full Name: empty spiraclesprovided by FlyBase
Primary source: FLYBASE:FBgn0000576
Locus tag: Dmel_CG2988
See related: AllianceGenome:FB:FBgn0000576
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ant; CG2988; Dmel\CG2988; E4; Ems; EMS; W13
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; nervous system development; and spiracle morphogenesis, open tracheal system. Located in nucleus. Is expressed in several structures, including anterior ectoderm anlage; ectoderm; extended germ band embryo; head segment; and presumptive embryonic/larval system. Orthologous to human EMX1 (empty spiracles homeobox 1) and EMX2 (empty spiracles homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 88A2-88A2; 3-54 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13901853..13904620)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9727575..9730342)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The phosphorylation of Hbn, Ems, and Msh may provide further insight into the function of Hipk during development of the Drosophila nervous system.
Title: Drosophila Homeodomain-Interacting Protein Kinase (Hipk) Phosphorylates the Homeodomain Proteins Homeobrain, Empty Spiracles, and Muscle Segment Homeobox.
Expression and function of empty spiracles gene in olfactory sense organ development.
Title: Expression and function of the empty spiracles gene in olfactory sense organ development of Drosophila melanogaster.
These results indicate that the anteroposterior patterning gene ems controls the expression of DV genes, and vice versa.
Title: Ems and Nkx6 are central regulators in dorsoventral patterning of the Drosophila brain.
Data show that Drosophila olfactory local interneurons and projection neurons derive from a common neuroblast lineage specified by the empty spiracles gene.
Title: Drosophila olfactory local interneurons and projection neurons derive from a common neuroblast lineage specified by the empty spiracles gene.
ems is required for the olfactory circuitry.
Title: Empty spiracles is required for the development of olfactory projection neuron circuitry in Drosophila.
Data show that ems gene is involved in the specification of the anterior brain during embryonic CNS development in Drosophila.
Title: Anteroposterior regionalization of the brain: genetic and comparative aspects.
ems is expressed in the mature adult brain and is autonomously required for the correct number of cells in the persistently expressing adult-specific lineage.
Title: Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior head segmentation	TAS Traceable Author Statement more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	NAS Non-traceable Author Statement more info	PubMed
involved_in brain segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic development via the syncytial blastoderm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pattern specification process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spiracle morphogenesis, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	IMP Inferred from Mutant Phenotype more info	PubMed