HNF1A HNF1 homeobox A [Gallus gallus (chicken)] - Gene

Summary

Symbol: HNF1Aprovided by CGNC
Full Name: HNF1 homeobox Aprovided by CGNC
Primary source: CGNC:5258
See related: Ensembl:ENSGALG00010022741
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: TCF1; LF-B1; TCF-1; HNF-1A; HNF-1alpha; HNF-1-alpha
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	15	NC_052546.1 (9110529..9125323, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	15	NC_052587.1 (9121080..9135900, complement)

Chromosome 15 - NC_052546.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggested that the functional defect of novel truncated HNF-1alpha (G554fsX556) on the transactivation of its target-gene promoters would account for the beta-cell dysfunction associated with the pathogenesis of MODY
Title: Functional defect of truncated hepatocyte nuclear factor-1alpha (G554fsX556) associated with maturity-onset diabetes of the young.
variant Hnf1 acts with fibroblast growth factor to promote caudal hindbrain identity by activating MafB and Kro x 20 expression
Title: vHnf1 regulates specification of caudal rhombomere identity in the chick hindbrain.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in liver development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in pancreas development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: hepatocyte nuclear factor 1-alpha

Names: albumin proximal factor; hepatic nuclear factor (HNF1); transcription factor 1, hepatic; transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030668.4 → NP_001025839.2 hepatocyte nuclear factor 1-alpha

Status: VALIDATED

Source sequence(s)

JAENSK010000260

UniProtKB/Swiss-Prot

Q90867

UniProtKB/TrEMBL

A0A1L1RPG1

Related

ENSGALP00010033461.1, ENSGALT00010055291.1

Conserved Domains (4) summary

cd00086
Location:203 → 276

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04812
Location:285 → 544

HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus

pfam04813
Location:547 → 633

HNF-1A_C; Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus

pfam04814
Location:8 → 170

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

9110529..9125323 complement

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GenBank, FASTA, Sequence Viewer (Graphics)