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    Nsf2 NEM-sensitive fusion protein 2 [ Drosophila melanogaster ]

    Gene ID: 41694, updated on 10-May-2012
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    Summary

    Official Symbol
    Nsf2provided by Flybase
    Official Full Name
    NEM-sensitive fusion protein 2provided by Flybase
    Primary source
    FLYBASE:FBgn0013998
    Locus tag
    Dmel_CG33101
    Gene type
    protein coding
    RNA name
    NEM-sensitive fusion protein 2
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33101; CG9931; Dmel\CG33101; DmNSF2; dNSF; dNSF-2; dnsf2; dNsf2; dNSF2; Nsf-2; NSF-2; NSF2
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    Genomic context

    Location :
    87F15-87F15
    Sequence :
    Chromosome: 3R; NT_033777.2 (9660195..9663708, complement)
    See Nsf2 in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene Male-specific RNA 87F Neighboring gene ncRNA Neighboring gene CG31495 gene product from transcript CG31495-RA Neighboring gene CG14362 gene product from transcript CG14362-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Drosophila Syntrophins are involved in locomotion and regulation of synaptic morphology. Nagai R, et al. Exp Cell Res, 2010 Aug 15. PMID 20632467.
    3. Moesin helps to restrain synaptic growth at the Drosophila neuromuscular junction. Seabrooke S, et al. Dev Neurobiol, 2008 Feb 15. PMID 18161855.
    4. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.
    5. The Release 5.1 annotation of Drosophila melanogaster heterochromatin. Smith CD, et al. Science, 2007 Jun 15. PMID 17569856.

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Interaction of cytoskeleton genes with NSF2-induced neuromuscular junction overgrowth suggests that NSF may function near the top of the actin regulatory pathway.
      Title: Interaction of cytoskeleton genes with NSF2-induced neuromuscular junction overgrowth.
    2. NSF2(E/Q) larval synapses indicate the NMJ overgrowth phenotype is present at the embryonic neuromuscular synapse. At the ultrastructural level, considerable alterations in the number and distribution of synapses and active zones were found.
      Title: Disruption of synaptic development and ultrastructure by Drosophila NSF2 alleles.
    3. genetic analysis of suppressors of NSF2 neuromuscular junction overgrowth
      Title: A genetic screen for suppressors of Drosophila NSF2 neuromuscular junction overgrowth.
    4. These data are consistent with a model in which actin filaments promote vesicle mobility and suggest that N-ethylmaleimide sensitive factor participates in establishing or maintaining this population of actin.
      Title: Synaptic vesicle mobility and presynaptic F-actin are disrupted in a N-ethylmaleimide-sensitive factor allele of Drosophila.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:66772 BioGRID:65370 Bet1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66772 BioGRID:59269 CG14216    BioGRID  PubMed Two-hybrid 
    BioGRID:66772 BioGRID:61844 CG1599    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66772 BioGRID:65929 CG2023    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66772 BioGRID:59869 CG3225    BioGRID  PubMed Two-hybrid 
    BioGRID:66772 BioGRID:66392 CG6208    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66772 BioGRID:65440 CG7757    BioGRID  PubMed Two-hybrid 
    BioGRID:66772 BioGRID:67310 Dl    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:66772 BioGRID:57823 N    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66772 BioGRID:57598 Sec22    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66772 BioGRID:68163 Ser    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:66772 BioGRID:59661 Slh    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66772 BioGRID:65495 Snap    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66772 BioGRID:78209 Snap25    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66772 BioGRID:61901 Syb    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:66772 BioGRID:67859 Syx18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66772 BioGRID:67788 Syx1A    BioGRID  PubMed Affinity Capture-MS; Phenotypic Enhancement 
    BioGRID:66772 BioGRID:60977 Syx5    BioGRID  PubMed Affinity Capture-MS; Phenotypic Enhancement 
    BioGRID:66772 BioGRID:65150 Syx8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66772 BioGRID:64451 Use1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66772 BioGRID:58180 Ykt6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66772 BioGRID:60424 bib    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:66772 BioGRID:70577 comt    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66772 BioGRID:65569 fng    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:66772 BioGRID:63423 gammaSnap    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66772 BioGRID:64080 membrin    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66772 BioGRID:59135 por    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:66772 BioGRID:63369 usnp    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66772 BioGRID:60155 wg    BioGRID  PubMed Phenotypic Enhancement 
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    General gene information

    Pathways from BioSystems

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoside-triphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    ER to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    ER to Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		  
    intra-Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		  
    neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of synaptic growth at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    synaptic vesicle priming NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG33101 gene product from transcript CG33101-RA
    Names
    CG33101-PA
    NEM-sensitive fusion protein 2
    Nsf2-PA
    NP_788676.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      9660195..9663708, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176499.1 → NP_788676.1  NEM-sensitive fusion protein 2 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54351
      Related
      FBpp0082346, FBtr0082883
      Conserved Domains (6) summary
      COG0464
      Location:247 – 733
      Blast Score: 442
      SpoVK; ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]
      cd00009
      Location:259 – 402
      Blast Score: 216
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart01073
      Location:9 – 89
      Blast Score: 171
      CDC48_N; Cell division protein 48 (CDC48) N-terminal domain
      pfam02359
      Location:9 – 90
      Blast Score: 147
      CDC48_N; Cell division protein 48 (CDC48), N-terminal domain
      cl08380
      Location:117 – 170
      Blast Score: 120
      CDC48_2; Cell division protein 48 (CDC48), domain 2
      cl09099
      Location:544 – 673
      Blast Score: 112
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014297.2 AAF54995.2
    mRNA BT023784.1 AAZ41793.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54351.2 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content