CG9588 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: CG9588provided by Flybase
Primary source: FLYBASE:FBgn0038166
Locus tag: Dmel_CG9588
Gene type: protein coding
RNA name: CG9588
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 9588; Dmel\CG9588

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Genomic context

Location :: 87F7-87F7

Sequence :: Chromosome: 3R; NT_033777.2 (9500814..9502398, complement)

See CG9588 in Epigenomics, MapViewer

Chromosome 3R - NT_033777.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:66752	BioGRID:66332	CG16817	BioGRID	PubMed	Affinity Capture-MS
BioGRID:66752	BioGRID:72813	CG18745	BioGRID	PubMed	Two-hybrid
BioGRID:66752	BioGRID:58991	CG32572	BioGRID	PubMed	Two-hybrid
BioGRID:66752	BioGRID:58064	CG3847	BioGRID	PubMed	Two-hybrid
BioGRID:66752	BioGRID:62020	CG9027	BioGRID	PubMed	Two-hybrid
BioGRID:66752	BioGRID:61822	Map60	BioGRID	PubMed	Two-hybrid
BioGRID:66752	BioGRID:58882	PGRP-LE	BioGRID	PubMed	Two-hybrid
BioGRID:66752	BioGRID:67764	Pros26.4	BioGRID	PubMed	Two-hybrid
BioGRID:66752	BioGRID:58056	Rpt4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:66752	BioGRID:64712	Rpt4R	BioGRID	PubMed	Two-hybrid
BioGRID:66752	BioGRID:67743	Tbp-1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:66752	BioGRID:67689	fzo	BioGRID	PubMed	Two-hybrid
BioGRID:66752	BioGRID:59482	lwr	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the CG9588 gene: The CG9588 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, C.elegans, S.cerevisiae, K.lactis, , , N.crassa, A.thaliana, and rice.

Pathways from BioSystems

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem (from REACTOME)
APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptosis, organism-specific biosystem (from REACTOME)
Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystem (from REACTOME)
Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystem (from REACTOME)
CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
Cell Cycle Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Replication, organism-specific biosystem (from REACTOME)
DNA Replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
Degradation of beta-catenin by the destruction complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1/S DNA Damage Checkpoints, organism-specific biosystem (from REACTOME)
G1/S DNA Damage Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
Orc1 removal from chromatin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Proteasome Degradation, organism-specific biosystem (from WikiPathways)
Proteasome Degradation, organism-specific biosystem
Proteasome Degradation
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Apoptosis, organism-specific biosystem (from REACTOME)
Regulation of Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of DNA replication, organism-specific biosystem (from REACTOME)
Regulation of DNA replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of activated PAK-2p34 by proteasome mediated degradation, organism-specific biosystem (from REACTOME)
Regulation of activated PAK-2p34 by proteasome mediated degradation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
Regulation of mitotic cell cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
Removal of licensing factors from origins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
S Phase, organism-specific biosystem (from REACTOME)
S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystem (from REACTOME)
SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Wnt, organism-specific biosystem (from REACTOME)
Signaling by Wnt, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
Switching of origins to a post-replicative state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis of DNA, organism-specific biosystem (from REACTOME)
Synthesis of DNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, organism-specific biosystem (from REACTOME)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ubiquitin-dependent degradation of Cyclin D, organism-specific biosystem (from REACTOME)
Ubiquitin-dependent degradation of Cyclin D, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ubiquitin-dependent degradation of Cyclin D1, organism-specific biosystem (from REACTOME)
Ubiquitin-dependent degradation of Cyclin D1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
p53-Independent DNA Damage Response, organism-specific biosystem (from REACTOME)
p53-Independent DNA Damage Response, organism-specific biosystemcomputationally inferred pathway (not manually curated)
p53-Independent G1/S DNA damage checkpoint, organism-specific biosystem (from REACTOME)
p53-Independent G1/S DNA damage checkpoint, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
proteolysis	ISS Inferred from Sequence or Structural Similarity more info
response to DNA damage stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
proteasome regulatory particle	ISS Inferred from Sequence or Structural Similarity more info

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General protein information

Preferred Names: CG9588 gene product from transcript CG9588-RA

Names: CG9588; CG9588-PA

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.2

Range

9500814..9502398, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_142044.3 → NP_650301.1 CG9588 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9VFS8

Related

FBpp0082314, FBtr0082849

Conserved Domains (1) summary

cd00136
Location:116 – 186
Blast Score: 119

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...