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PK2-R1 Pyrokinin 2 receptor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41639, updated on 4-Apr-2024

Summary

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Official Symbol
PK2-R1provided by FlyBase
Official Full Name
Pyrokinin 2 receptor 1provided by FlyBase
Primary source
FLYBASE:FBgn0038140
Locus tag
Dmel_CG8784
See related
AllianceGenome:FB:FBgn0038140
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0170980.190; anon-WO0170980.191; CG8784; Dm CG8784; Dmel\CG8784; Pyrokinin2 R
Summary
Enables pyrokinin receptor activity. Involved in neuropeptide signaling pathway. Is integral component of plasma membrane. Orthologous to human NMUR1 (neuromedin U receptor 1) and NMUR2 (neuromedin U receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PK2-R1 in Genome Data Viewer
Location:
87E6-87E6; 3-53 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13338330..13345106)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9164052..9170828)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pyrokinin 2 receptor 2 Neighboring gene methuselah-like 12 Neighboring gene Elongator complex protein 6 Neighboring gene Dicarboxylate carrier 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fraenkel's pupariation factor identified at last. Verleyen P, et al. Dev Biol, 2004 Sep 1. PMID 15302596
  2. Comparative neuroanatomy and genomics of hugin and pheromone biosynthesis activating neuropeptide (PBAN). Bader R, et al. Fly (Austin), 2007 Jul-Aug. PMID 18820431
  3. Synaptic transmission parallels neuromodulation in a central food-intake circuit. Schlegel P, et al. Elife, 2016 Nov 15. PMID 27845623, Free PMC Article
  4. The Drosophila gene CG9918 codes for a pyrokinin-1 receptor. Cazzamali G, et al. Biochem Biophys Res Commun, 2005 Sep 16. PMID 16054112
  5. An obligatory role for neurotensin in high-fat-diet-induced obesity. Li J, et al. Nature, 2016 May 19. PMID 27193687, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide receptor activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables pyrokinin receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
pyrokinin 2 receptor 1
Names
CG8784-PA
PK2-R1-PA
hugin receptor
pyrokinin 2 receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13338330..13345106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169507.3 → NP_731790.1  pyrokinin 2 receptor 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731790.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8ITD1, Q9VFW5
    Related
    FBpp0082213
    Conserved Domains (2) summary
    pfam00001
    Location:124 → 388
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:114 → 242
    7tm_4; Olfactory receptor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6WNX8 Q6WNX8
Q8ITD1 Q8ITD1
Q9VFW5 Q9VFW5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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