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    CtBP C-terminal Binding Protein [ Drosophila melanogaster ]

    Gene ID: 41602, updated on 19-May-2012
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    Summary

    Official Symbol
    CtBPprovided by Flybase
    Official Full Name
    C-terminal Binding Proteinprovided by Flybase
    Primary source
    FLYBASE:FBgn0020496
    Locus tag
    Dmel_CG7583
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0256/16; 256/16; BcDNA:GH07572; CG7583; ctbp; CTBP; dCtBP; Dm-CtBP; Dmel\CG7583; EP(3)3528; G9; l(3)03463; l(3)03464; l(3)87De; l(3)87DE; l(3)G9; RE01030; RE61183
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    Genomic context

    Location :
    87D8-87D9
    Sequence :
    Chromosome: 3R; NT_033777.2 (8837388..8851905)
    See CtBP in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene CG7518 gene product from transcript CG7518-RD Neighboring gene CG8031 gene product from transcript CG8031-RA Neighboring gene CG11656 gene product from transcript CG11656-RA Neighboring gene CG12360 gene product from transcript CG12360-RA Neighboring gene lethal (3) 87Df

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. C-terminal binding protein-mediated transcriptional repression is regulated by X-linked inhibitor of apoptosis protein. Lee JS, et al. Biochem Biophys Res Commun, 2012 Jan 6. PMID 22138398.
    2. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    3. Fine tuning of Notch signaling by differential co-repressor recruitment during eye development of Drosophila. Nagel AC, et al. Hereditas, 2011 Jun. PMID 21756252.
    4. The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets. Bhambhani C, et al. EMBO J, 2011 May 18. PMID 21468031.
    5. Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression. Abed M, et al. EMBO J, 2011 Apr 6. PMID 21343912.

    See all (135) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Drosophila CtBP (dCtBP) was identified as a binding partner of Diap1; whether the interaction between Diap1 and dCtBP also occurs in human cells was tested.
      Title: C-terminal binding protein-mediated transcriptional repression is regulated by X-linked inhibitor of apoptosis protein.
    2. Data show that the differential recruitment of the co-repressors Gro and CtBP by H in a context-dependent manner ensures fine tuning of Notch signaling activity during eye development.
      Title: Fine tuning of Notch signaling by differential co-repressor recruitment during eye development of Drosophila.
    3. These results support a model where CtBP is a gene-specific regulator of Wingless signalling, with some targets requiring CtBP dimers for inhibition while other targets utilize CtBP monomers for activation of their expression.
      Title: The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets.
    4. Results indicate that the structural and enzymatic features of C-terminal binding protein are critical for modulating this protein's activity in diverse developmental settings.
      Title: Conserved catalytic and C-terminal regulatory domains of the C-terminal binding protein corepressor fine-tune the transcriptional response in development.
    5. CtBP regulates expression of intergenic transcripts that controls DNA binding by PcG proteins and subsequent histone modifications and transcriptional activity.
      Title: CtBP levels control intergenic transcripts, PHO/YY1 DNA binding, and PcG recruitment to DNA.
    6. dCtBP is part of a gene circuitry that controls the patterning and differentiation of the fly peripheral nervous system via multiple mechanisms
      Title: CtBP is required for proper development of peripheral nervous system in Drosophila.
    7. These data, taken together, suggest that AN is functionally distinct from dCtBP.
      Title: Structurally related Arabidopsis ANGUSTIFOLIA is functionally distinct from the transcriptional corepressor CtBP.
    8. the ancestral dehydrogenase activity is not required for CtBP function, and NAD binding may play a regulatory, rather than catalytic, role
      Title: Role of NAD binding and catalytic residues in the C-terminal binding protein corepressor.
    9. AChE's 3' alternative splicing, and the corresponding changes in AChE-S/CtBP interactions, thus emerge as being actively involved in controlling hematopoiesis
      Title: Acetylcholinesterase/C terminal binding protein interactions modify Ikaros functions, causing T lymphopenia.
    10. Here, we discuss the cytoplasmic roles of the CtBPs and the possible mechanisms that enable them to switch between cell compartments and multiple functions.
      Title: The multiple activities of CtBP/BARS proteins: the Golgi view.
    Submit: New GeneRIF Correction See all (20)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_524336.2 NP_477430.1 Apc2    BIND  PubMed dCtBP interacts with E-APC. 
    NP_524336.2 NP_732533.1 H    BIND  PubMed Hairless interacts with dCtBP. 
    BioGRID:66690 BioGRID:61126 CG10348    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:65988 CG1041    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:64868 CG10710    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:58678 CG12725    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:65741 CG12768    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66690 BioGRID:66793 CG14357    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:63012 CG15649    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:63052 CG15658    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:63347 CG30183    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:59869 CG3225    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:77495 CG33052    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:57730 CG3630    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:58058 CG3815    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66690 BioGRID:58133 CG4617    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:62290 CG6543    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66690 BioGRID:59164 CG6617    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66690 BioGRID:64659 CG7512    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:66769 CG9286    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:64967 CTPsyn    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:66690 BioGRID:67421 H    BioGRID  PubMed Phenotypic Enhancement; Two-hybrid 
    BioGRID:66690 BioGRID:60119 Hrb27C    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:59683 Hrs    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:71509 Hsp60B    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:63578 Kr    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:66690 BioGRID:65742 Mes2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66690 BioGRID:57823 N    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66690 BioGRID:63097 NC2alpha    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:66823 NK7.1    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:63390 Nap1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66690 BioGRID:63410 Pask    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:66054 Sas-4    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:60899 Su(H)    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:66690 BioGRID:58141 brk    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:69912 bur    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:67940 danr    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:58921 disco    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:61043 dl    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:65668 eg    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:60919 esg    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:57548 ewg    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:68062 gro    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66690 BioGRID:57763 gt    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:64402 h    BioGRID  PubMed Phenotypic Suppression; Reconstituted Complex 
    BioGRID:66690 BioGRID:65544 kni    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:66690 BioGRID:65542 knrl    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:60002 lid    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66690 BioGRID:62753 pAbp    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:69326 pnr    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:66690 BioGRID:59347 run    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66690 BioGRID:60924 sna    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:66690 BioGRID:65303 star1    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:62194 sug    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:68506 tll    BioGRID  PubMed Two-hybrid 
    BioGRID:66690 BioGRID:71315 ttk    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:66690 BioGRID:57797 ttm50    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the CtBP gene: The CtBP gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, S.pombe, , and N.crassa.

    Pathways from BioSystems

    • Notch signaling pathway, organism-specific biosystem (from KEGG)
      Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch signaling pathway, conserved biosystem (from KEGG)
      Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein C-terminus binding NAS
    Non-traceable Author Statement
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		  
    repressing transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transcription corepressor activity NAS
    Non-traceable Author Statement
    more info
    		  
    transcription corepressor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    Wnt receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    embryonic development via the syncytial blastoderm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of Wnt receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		  
    wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG7583 gene product from transcript CG7583-RE
    Names
    C-terminal binding protein
    C-terminal-Binding-Protein
    C-terminal-binding protein
    CG7583-PA
    CG7583-PB
    CG7583-PC
    CG7583-PD
    CG7583-PE
    CtBP-PA
    CtBP-PB
    CtBP-PC
    CtBP-PD
    CtBP-PE
    lethal(3)87De
    NP_001014617.1
    NP_524336.2
    NP_731762.1
    NP_731763.1
    NP_731764.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      8837388..8851905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014617.1 → NP_001014617.1  C-terminal binding protein, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46036
      Related
      FBpp0099514, FBtr0100161
      Conserved Domains (2) summary
      pfam00389
      Location:32 – 352
      Blast Score: 631
      2-Hacid_dh; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
      cl09931
      Location:133 – 317
      Blast Score: 521
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_079612.2 → NP_524336.2  C-terminal binding protein, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2S3
      UniProtKB/Swiss-Prot
      O46036
      Related
      FBpp0082167, FBtr0082699
      Conserved Domains (2) summary
      pfam00389
      Location:32 – 352
      Blast Score: 622
      2-Hacid_dh; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
      cl09931
      Location:133 – 317
      Blast Score: 519
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_169491.1 → NP_731763.1  C-terminal binding protein, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2S3
      UniProtKB/Swiss-Prot
      O46036
      Related
      FBpp0082168, FBtr0082700
      Conserved Domains (2) summary
      pfam00389
      Location:32 – 352
      Blast Score: 622
      2-Hacid_dh; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
      cl09931
      Location:133 – 317
      Blast Score: 519
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. NM_169490.1 → NP_731762.1  C-terminal binding protein, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2S3
      UniProtKB/Swiss-Prot
      O46036
      Related
      FBpp0082169, FBtr0082701
      Conserved Domains (2) summary
      pfam00389
      Location:32 – 352
      Blast Score: 622
      2-Hacid_dh; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
      cl09931
      Location:133 – 317
      Blast Score: 519
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    5. NM_169492.1 → NP_731764.1  C-terminal binding protein, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2S3
      UniProtKB/Swiss-Prot
      O46036
      Related
      FBpp0082170, FBtr0082702
      Conserved Domains (2) summary
      pfam00389
      Location:32 – 352
      Blast Score: 622
      2-Hacid_dh; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
      cl09931
      Location:133 – 317
      Blast Score: 519
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014297.2 AAX52947.1
    genomic AE014297.2 AAF54891.1
    genomic AE014297.2 AAF54892.1
    genomic AE014297.2 AAN14340.1
    genomic AE014297.2 AAN14339.1
    mRNA AY069170.1 AAL39315.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46036.3 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content